Abstract:
:Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic potentiation in some cases. Thus, ADF/cofilin may have distinct effects on postsynaptic structure and function. We found that ADF/cofilin-mediated actin dynamics regulated AMPA receptor (AMPAR) trafficking during synaptic potentiation, which was distinct from actin's structural role in spine morphology. Specifically, elevated ADF/cofilin activity markedly enhanced surface addition of AMPARs after chemically induced long-term potentiation (LTP), whereas inhibition of ADF/cofilin abolished AMPAR addition. We found that chemically induced LTP elicited a temporal sequence of ADF/cofilin dephosphorylation and phosphorylation that underlies AMPAR trafficking and spine enlargement. These findings suggest that temporally regulated ADF/cofilin activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Gu J,Lee CW,Fan Y,Komlos D,Tang X,Sun C,Yu K,Hartzell HC,Chen G,Bamburg JR,Zheng JQdoi
10.1038/nn.2634subject
Has Abstractpub_date
2010-10-01 00:00:00pages
1208-15issue
10eissn
1097-6256issn
1546-1726pii
nn.2634journal_volume
13pub_type
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