Contrast gain control and cortical TrkB signaling shape visual acuity.

abstract：:Although de novo missense mutations have been predicted to account for more cases of autism than gene-truncating mutations, most research has focused on the latter. We identified the properties of de novo missense mutations in patients with neurodevelopmental disorders (NDDs) and highlight 35 genes with excess missens...

journal_title：Nature neuroscience

authors： Geisheker MR,Heymann G,Wang T,Coe BP,Turner TN,Stessman HAF,Hoekzema K,Kvarnung M,Shaw M,Friend K,Liebelt J,Barnett C,Thompson EM,Haan E,Guo H,Anderlid BM,Nordgren A,Lindstrand A,Vandeweyer G,Alberti A,Avola E,V

更新日期：2017-08-01 00:00:00

abstract：:Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped patte...

journal_title：Nature neuroscience

authors： Huberman AD,Murray KD,Warland DK,Feldheim DA,Chapman B

更新日期：2005-08-01 00:00:00

abstract：:When sleep followed implicit training on a motor sequence, children showed greater gains in explicit sequence knowledge after sleep than adults. This greater explicit knowledge in children was linked to their higher sleep slow-wave activity and to stronger hippocampal activation at explicit knowledge retrieval. Our da...

journal_title：Nature neuroscience

authors： Wilhelm I,Rose M,Imhof KI,Rasch B,Büchel C,Born J

更新日期：2013-04-01 00:00:00

abstract：:Dendritic spines are motile structures that contain high concentrations of filamentous actin. Using hippocampal neurons expressing fluorescent actin and the method of fluorescence recovery after photobleaching, we found that 85 +/- 2% of actin in the spine was dynamic, with a turnover time of 44.2 +/- 4.0 s. The rapid...

journal_title：Nature neuroscience

authors： Star EN,Kwiatkowski DJ,Murthy VN

更新日期：2002-03-01 00:00:00

abstract：:We delineated a heritable phenotype resulting from the self-administration of cocaine in rats. We observed delayed acquisition and reduced maintenance of cocaine self-administration in male, but not female, offspring of sires that self-administered cocaine. Brain-derived neurotrophic factor (Bdnf) mRNA and BDNF protei...

journal_title：Nature neuroscience

authors： Vassoler FM,White SL,Schmidt HD,Sadri-Vakili G,Pierce RC

更新日期：2013-01-01 00:00:00

abstract：:A localized transcriptome at the synapse facilitates synapse-, stimulus- and transcript-specific local protein synthesis in response to neuronal activity. While enzyme-mediated mRNA modifications are known to regulate cellular mRNA turnover, the role of these modifications in regulating synaptic RNA has not been studi...

journal_title：Nature neuroscience

authors： Merkurjev D,Hong WT,Iida K,Oomoto I,Goldie BJ,Yamaguti H,Ohara T,Kawaguchi SY,Hirano T,Martin KC,Pellegrini M,Wang DO

更新日期：2018-07-01 00:00:00

abstract：:The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...

journal_title：Nature neuroscience

authors： Liu J,Ward A,Gao J,Dong Y,Nishio N,Inada H,Kang L,Yu Y,Ma D,Xu T,Mori I,Xie Z,Xu XZ

更新日期：2010-06-01 00:00:00

abstract：:Active dendritic integration is thought to enrich the computational power of central neurons. However, a direct role of active dendritic processing in the execution of defined neuronal computations in intact neural networks has not been established. Here we used multi-site electrophysiological recording techniques to ...

journal_title：Nature neuroscience

authors： Sivyer B,Williams SR

更新日期：2013-12-01 00:00:00

abstract：:Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neuro...

journal_title：Nature neuroscience

authors： Magee JC,Cook EP

更新日期：2000-09-01 00:00:00

abstract：:Declarative memory, the conscious recollection of past experiences, is known to involve the hippocampus. Now a study of amnesic patients shows that hippocampus-dependent learning can occur in the absence of conscious awareness. ...

journal_title：Nature neuroscience

authors： Eichenbaum H

更新日期：1999-09-01 00:00:00

abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...

journal_title：Nature neuroscience

authors： Lischinsky JE,Lin D

更新日期：2020-11-01 00:00:00

abstract：:Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...

journal_title：Nature neuroscience

authors： Sreenivasan S,Fiete I

更新日期：2011-09-11 00:00:00

abstract：:Breathing is a bilaterally synchronous behavior that relies on a respiratory rhythm generator located in the brainstem. An essential component of this generator is the preBötzinger complex (preBötC), which paces inspirations. Little is known about the developmental origin of the interneuronal populations forming the p...

journal_title：Nature neuroscience

authors： Bouvier J,Thoby-Brisson M,Renier N,Dubreuil V,Ericson J,Champagnat J,Pierani A,Chédotal A,Fortin G

更新日期：2010-09-01 00:00:00

abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...

journal_title：Nature neuroscience

authors： Sangiamo DT,Warren MR,Neunuebel JP

更新日期：2020-03-01 00:00:00

abstract：:In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAM...

journal_title：Nature neuroscience

authors： Cygnar KD,Zhao H

更新日期：2009-04-01 00:00:00

abstract：:We studied how the posterior parietal cortex combines new information with ongoing activity dynamics as mice accumulate evidence during a virtual navigation task. Using new methods to analyze population activity on single trials, we found that activity transitioned rapidly between different sets of active neurons. Eac...

journal_title：Nature neuroscience

authors： Morcos AS,Harvey CD

更新日期：2016-12-01 00:00:00

abstract：:Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses,...

journal_title：Nature neuroscience

authors： Burgos-Robles A,Kimchi EY,Izadmehr EM,Porzenheim MJ,Ramos-Guasp WA,Nieh EH,Felix-Ortiz AC,Namburi P,Leppla CA,Presbrey KN,Anandalingam KK,Pagan-Rivera PA,Anahtar M,Beyeler A,Tye KM

更新日期：2017-06-01 00:00:00

abstract：:The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying...

journal_title：Nature neuroscience

authors： Kiecker C,Lumsden A

更新日期：2004-11-01 00:00:00

abstract：:Amyloid plaques are a hallmark of Alzheimer disease, but their importance in its pathogenesis is controversial. By neuronal labeling and transcranial two-photon imaging, we show in a transgenic mouse model of Alzheimer disease that dendrites passing through or near fibrillar amyloid deposits undergo spine loss and sha...

journal_title：Nature neuroscience

authors： Tsai J,Grutzendler J,Duff K,Gan WB

更新日期：2004-11-01 00:00:00

abstract：:Using magnetoencephalography (MEG), we compared the processing of sinusoidal tones in the auditory cortex of 12 non-musicians, 12 professional musicians and 13 amateur musicians. We found neurophysiological and anatomical differences between groups. In professional musicians as compared to non-musicians, the activity ...

journal_title：Nature neuroscience

authors： Schneider P,Scherg M,Dosch HG,Specht HJ,Gutschalk A,Rupp A

更新日期：2002-07-01 00:00:00

abstract：:Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...

journal_title：Nature neuroscience

authors： Panov AV,Gutekunst CA,Leavitt BR,Hayden MR,Burke JR,Strittmatter WJ,Greenamyre JT

更新日期：2002-08-01 00:00:00

abstract：:Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning. Our goal is to demonstrate how specific models emerging from the computational app...

journal_title：Nature neuroscience

authors： Wolpert DM,Ghahramani Z

更新日期：2000-11-01 00:00:00

abstract：:Many of the behavioral consequences of stress are mediated by the activation of the glucocorticoid receptor by stress-induced high levels of glucocorticoid hormones. To explore the molecular mechanisms of these effects, we combined in vivo and in vitro approaches. We analyzed mice carrying a brain-specific mutation (G...

journal_title：Nature neuroscience

authors： Revest JM,Di Blasi F,Kitchener P,Rougé-Pont F,Desmedt A,Turiault M,Tronche F,Piazza PV

更新日期：2005-05-01 00:00:00

abstract：:We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...

journal_title：Nature neuroscience

authors： Hershfinkel M,Kandler K,Knoch ME,Dagan-Rabin M,Aras MA,Abramovitch-Dahan C,Sekler I,Aizenman E

更新日期：2009-06-01 00:00:00

abstract：:Central pattern generators (CPGs) are spinal neuronal networks required for locomotion. Glutamatergic neurons have been implicated as being important for intrinsic rhythm generation in the CPG and for the command signal for initiating locomotion, although this has not been demonstrated directly. We used a newly genera...

journal_title：Nature neuroscience

authors： Hägglund M,Borgius L,Dougherty KJ,Kiehn O

更新日期：2010-02-01 00:00:00

abstract：:T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...

journal_title：Nature neuroscience

authors： Garber C,Soung A,Vollmer LL,Kanmogne M,Last A,Brown J,Klein RS

更新日期：2019-08-01 00:00:00

abstract：:The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental q...

journal_title：Nature neuroscience

authors： Xie J,Padoa-Schioppa C

更新日期：2016-06-01 00:00:00

abstract：:Over the past two centuries, prevalent models of energy and glucose homeostasis have emerged from careful anatomical descriptions in tandem with an understanding of cellular physiology. More recent technological advances have culminated in the identification of peripheral and central factors that influence neural circ...

journal_title：Nature neuroscience

authors： Williams KW,Elmquist JK

更新日期：2012-10-01 00:00:00

abstract：:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...

journal_title：Nature neuroscience

authors： Stoodley CJ,D'Mello AM,Ellegood J,Jakkamsetti V,Liu P,Nebel MB,Gibson JM,Kelly E,Meng F,Cano CA,Pascual JM,Mostofsky SH,Lerch JP,Tsai PT

更新日期：2017-12-01 00:00:00

abstract：:In the version of this article initially published, the annotation accompanying ref. 47 ended with "though the modulation of microglia." The first word of this phrase should have been "through." The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature neuroscience

authors： Deczkowska A,Amit I,Schwartz M

更新日期：2018-08-01 00:00:00