Conscious awareness, memory and the hippocampus.

abstract：:Many of the behavioral consequences of stress are mediated by the activation of the glucocorticoid receptor by stress-induced high levels of glucocorticoid hormones. To explore the molecular mechanisms of these effects, we combined in vivo and in vitro approaches. We analyzed mice carrying a brain-specific mutation (G...

journal_title：Nature neuroscience

authors： Revest JM,Di Blasi F,Kitchener P,Rougé-Pont F,Desmedt A,Turiault M,Tronche F,Piazza PV

更新日期：2005-05-01 00:00:00

abstract：:PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid-β (Aβ) pathology and cognitive impairment. Moreover, Picalm deficiency diminished Aβ clearance across the murine blood-brain barrier (BBB)...

journal_title：Nature neuroscience

authors： Zhao Z,Sagare AP,Ma Q,Halliday MR,Kong P,Kisler K,Winkler EA,Ramanathan A,Kanekiyo T,Bu G,Owens NC,Rege SV,Si G,Ahuja A,Zhu D,Miller CA,Schneider JA,Maeda M,Maeda T,Sugawara T,Ichida JK,Zlokovic BV

更新日期：2015-07-01 00:00:00

abstract：:Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial re...

journal_title：Nature neuroscience

authors： Murray AJ,Sauer JF,Riedel G,McClure C,Ansel L,Cheyne L,Bartos M,Wisden W,Wulff P

更新日期：2011-03-01 00:00:00

abstract：:To discover novel genes underlying amyotrophic lateral sclerosis (ALS), we aggregated exomes from 3,864 cases and 7,839 ancestry-matched controls. We observed a significant excess of rare protein-truncating variants among ALS cases, and these variants were concentrated in constrained genes. Through gene level analyses...

journal_title：Nature neuroscience

authors： Farhan SMK,Howrigan DP,Abbott LE,Klim JR,Topp SD,Byrnes AE,Churchhouse C,Phatnani H,Smith BN,Rampersaud E,Wu G,Wuu J,Shatunov A,Iacoangeli A,Al Khleifat A,Mordes DA,Ghosh S,ALSGENS Consortium.,FALS Consortium.,Proje

更新日期：2019-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Rothschild G,Nelken I,Mizrahi A

更新日期：2020-11-01 00:00:00

abstract：:Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this vulnerability is not understood. To explore possible physiological determinants, we studied LC neurons using electrophysiological and optical approa...

journal_title：Nature neuroscience

authors： Sanchez-Padilla J,Guzman JN,Ilijic E,Kondapalli J,Galtieri DJ,Yang B,Schieber S,Oertel W,Wokosin D,Schumacker PT,Surmeier DJ

更新日期：2014-06-01 00:00:00

abstract：:Activity in the primary auditory cortex (A1) is essential for normal sound localization behavior, but previous studies of the spatial sensitivity of neurons in A1 have found broad spatial tuning. We tested the hypothesis that spatial tuning sharpens when an animal engages in an auditory task. Cats performed a task tha...

journal_title：Nature neuroscience

authors： Lee CC,Middlebrooks JC

更新日期：2011-01-01 00:00:00

abstract：:In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature neuroscience

authors： Marek R,Jin J,Goode TD,Giustino TF,Wang Q,Acca GM,Holehonnur R,Ploski JE,Fitzgerald PJ,Lynagh T,Lynch JW,Maren S,Sah P

更新日期：2018-09-01 00:00:00

abstract：:To investigate synaptic events underlying sensory perception, we made whole-cell membrane potential recordings of barrel cortex neurons in awake mice while recording whisker-related behavior. During quiet periods, we recorded slow, large-amplitude membrane potential changes, which switched during whisking to small, fa...

journal_title：Nature neuroscience

authors： Crochet S,Petersen CC

更新日期：2006-05-01 00:00:00

abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...

journal_title：Nature neuroscience

authors： Sangiamo DT,Warren MR,Neunuebel JP

更新日期：2020-03-01 00:00:00

abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...

journal_title：Nature neuroscience

authors： Petersen PH,Zou K,Krauss S,Zhong W

更新日期：2004-08-01 00:00:00

abstract：:Neuroimaging studies show that the efficacy of long-term memory encoding of a stimulus is indexed by transient neural activity elicited by that stimulus. Here, we show that successful memory encoding is also indexed by neural activity that is tonically maintained throughout a study task. Using functional magnetic reso...

journal_title：Nature neuroscience

authors： Otten LJ,Henson RN,Rugg MD

更新日期：2002-12-01 00:00:00

abstract：:The usefulness of genetically encoded probes for optical monitoring of neuronal activity and brain circuits would be greatly advanced by the generation of multiple indicators with non-overlapping color spectra. Most existing indicators are derived from or spectrally convergent on GFP. We generated a bright, red, pH-se...

journal_title：Nature neuroscience

authors： Li Y,Tsien RW

更新日期：2012-05-27 00:00:00

abstract：:Neural stem and progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes and oligodendrocytes. However, the mechanisms underlying the decision of a stem cell to either self-renew or differentiate are incompletely understood. We demonstrate here that Fbw7 (F-box and WD repeat domain containing-7), the substrate re...

journal_title：Nature neuroscience

authors： Hoeck JD,Jandke A,Blake SM,Nye E,Spencer-Dene B,Brandner S,Behrens A

更新日期：2010-11-01 00:00:00

abstract：:Rapid eye movement (REM) sleep has been considered important for consolidation of memories, particularly of skills. Contrary to expectations, we found that REM sleep suppression by administration of selective serotonin or norepinephrine re-uptake inhibitors after training did not impair consolidation of skills or word...

journal_title：Nature neuroscience

authors： Rasch B,Pommer J,Diekelmann S,Born J

更新日期：2009-04-01 00:00:00

abstract：:Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation has been implicated in a wide range of diseases. Here we demonstrate that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like recepto...

journal_title：Nature neuroscience

authors： Hess ME,Hess S,Meyer KD,Verhagen LA,Koch L,Brönneke HS,Dietrich MO,Jordan SD,Saletore Y,Elemento O,Belgardt BF,Franz T,Horvath TL,Rüther U,Jaffrey SR,Kloppenburg P,Brüning JC

更新日期：2013-08-01 00:00:00

abstract：:In higher sensory cortices, there is a gradual transformation from sensation to perception and action. In the auditory system, this transformation is revealed by responses in the rostral ventral posterior auditory field (VPr), a tertiary area in the ferret auditory cortex, which shows long-term learning in trained com...

journal_title：Nature neuroscience

authors： Elgueda D,Duque D,Radtke-Schuller S,Yin P,David SV,Shamma SA,Fritz JB

更新日期：2019-03-01 00:00:00

abstract：:We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improv...

journal_title：Nature neuroscience

authors： McNamara CG,Tejero-Cantero Á,Trouche S,Campo-Urriza N,Dupret D

更新日期：2014-12-01 00:00:00

abstract：:Long-term synaptic changes, which are essential for learning and memory, are dependent on homeostatic mechanisms that stabilize neural activity. Homeostatic responses have also been implicated in pathological conditions, including nicotine addiction. Although multiple homeostatic pathways have been described, little i...

journal_title：Nature neuroscience

authors： Ping Y,Tsunoda S

更新日期：2011-11-13 00:00:00

abstract：:The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for vocal learning in juvenile songbirds. The shell subregion of LMAN (LMAN(shell)) gives rise to recurrent loops that may subserve specific learning-related functions....

journal_title：Nature neuroscience

authors： Bottjer SW,Altenau B

更新日期：2010-02-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Marschallinger J,Iram T,Zardeneta M,Lee SE,Lehallier B,Haney MS,Pluvinage JV,Mathur V,Hahn O,Morgens DW,Kim J,Tevini J,Felder TK,Wolinski H,Bertozzi CR,Bassik MC,Aigner L,Wyss-Coray T

更新日期：2020-02-01 00:00:00

abstract：:In the version of this article initially published, the annotation accompanying ref. 47 ended with "though the modulation of microglia." The first word of this phrase should have been "through." The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature neuroscience

authors： Deczkowska A,Amit I,Schwartz M

更新日期：2018-08-01 00:00:00

abstract：:Neuronal migration disorders such as lissencephaly and subcortical band heterotopia are associated with epilepsy and intellectual disability. DCX, PAFAH1B1 and TUBA1A are mutated in these disorders; however, corresponding mouse mutants do not show heterotopic neurons in the neocortex. In contrast, spontaneously arisen...

journal_title：Nature neuroscience

authors： Kielar M,Tuy FP,Bizzotto S,Lebrand C,de Juan Romero C,Poirier K,Oegema R,Mancini GM,Bahi-Buisson N,Olaso R,Le Moing AG,Boutourlinsky K,Boucher D,Carpentier W,Berquin P,Deleuze JF,Belvindrah R,Borrell V,Welker E,Chel

更新日期：2014-07-01 00:00:00

abstract：:The 'cognitive map' hypothesis proposes that brain builds a unified representation of the spatial environment to support memory and guide future action. Forty years of electrophysiological research in rodents suggest that cognitive maps are neurally instantiated by place, grid, border and head direction cells in the h...

journal_title：Nature neuroscience

authors： Epstein RA,Patai EZ,Julian JB,Spiers HJ

更新日期：2017-10-26 00:00:00

abstract：:Human behavior is mostly composed of habitual actions that require little conscious control. Such actions may become invalid if the environment changes, at which point individuals need to switch behavior by overcoming habitual actions that are otherwise triggered automatically. It is unknown how the brain controls thi...

journal_title：Nature neuroscience

authors： Isoda M,Hikosaka O

更新日期：2007-02-01 00:00:00

abstract：:Differentiation of CNS glia is regulated by Notch signaling through neuron-glia interaction. Here, we identified Delta/Notch-like EGF-related receptor (DNER), a neuron-specific transmembrane protein, as a previously unknown ligand of Notch during cellular morphogenesis of Bergmann glia in the mouse cerebellum. DNER bi...

journal_title：Nature neuroscience

authors： Eiraku M,Tohgo A,Ono K,Kaneko M,Fujishima K,Hirano T,Kengaku M

更新日期：2005-07-01 00:00:00

abstract：:The efficiency of remyelination decreases with age, but the molecular mechanisms responsible for this decline remain only partially understood. In this study, we show that remyelination is regulated by age-dependent epigenetic control of gene expression. In demyelinated young brains, new myelin synthesis is preceded b...

journal_title：Nature neuroscience

authors： Shen S,Sandoval J,Swiss VA,Li J,Dupree J,Franklin RJ,Casaccia-Bonnefil P

更新日期：2008-09-01 00:00:00

abstract：:Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By co...

journal_title：Nature neuroscience

authors： Torborg CL,Hansen KA,Feller MB

更新日期：2005-01-01 00:00:00

abstract：:Most neurons in macaque area MT are selective for the direction of stimulus motion. By comparing direction selectivity for gratings and plaids, we classified MT neurons as pattern direction selective (PDS) or component direction selective (CDS). We compared the time course of responses in CDS and PDS neurons in opiate...

journal_title：Nature neuroscience

authors： Smith MA,Majaj NJ,Movshon JA

更新日期：2005-02-01 00:00:00

abstract：:Uncovering the functional relationship between temporal lobe amnesia and diencephalic amnesia depends on determining the role of the fornix, the major interlinking fiber tract. In this study relating fornix volume with memory, we made magnetic resonance imaging-based volume estimates of 13 brain structures in 38 indiv...

journal_title：Nature neuroscience

authors： Tsivilis D,Vann SD,Denby C,Roberts N,Mayes AR,Montaldi D,Aggleton JP

更新日期：2008-07-01 00:00:00