Abstract：
:When sleep followed implicit training on a motor sequence, children showed greater gains in explicit sequence knowledge after sleep than adults. This greater explicit knowledge in children was linked to their higher sleep slow-wave activity and to stronger hippocampal activation at explicit knowledge retrieval. Our data indicate the superiority of children in extracting invariant features from complex environments, possibly as a result of enhanced reprocessing of hippocampal memory representations during slow-wave sleep.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Wilhelm I,Rose M,Imhof KI,Rasch B,Büchel C,Born Jdoi
10.1038/nn.3343subject
Has Abstractpub_date
2013-04-01 00:00:00pages
391-3issue
4eissn
1097-6256issn
1546-1726pii
nn.3343journal_volume
16pub_type
杂志文章,随机对照试验abstract：:A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1593
更新日期：2006-01-01 00:00:00
abstract：:In the published version of this article, a data point is missing from Fig. 4f, and the y-axis label reads "RFpre"; it should read "RFpref." The original article has not been corrected. The original and corrected figures are shown in the accompanying Publisher Correction. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0181-6
更新日期：2018-09-01 00:00:00
abstract：:Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and neuroanatomical distribution of pTDP-43 accumulations allowed classification of FTLD cases in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0294-y
更新日期：2019-01-01 00:00:00
abstract：:Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-s...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3785
更新日期：2014-09-01 00:00:00
abstract：:Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1150
更新日期：2003-12-01 00:00:00
abstract：:Rhythmic movements, such as walking, chewing or scratching, are phylogenetically old motor behaviors found in many organisms, ranging from insects to primates. In contrast, discrete movements, such as reaching, grasping or kicking, are behaviors that have reached sophistication primarily in younger species, particular...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1322
更新日期：2004-10-01 00:00:00
abstract：:The accessory olfactory bulb (AOB) is a critical olfactory structure that has been implicated in mediating social behavior. It receives input from the vomeronasal organ and projects to targets in the amygdaloid complex. Its anterior and posterior components (aAOB and pAOB) display molecular, connectional and functiona...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3297
更新日期：2013-02-01 00:00:00
abstract：:Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected that microglia would contribute to neurodegeneration. Howeve...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0083-7
更新日期：2018-03-01 00:00:00
abstract：:Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4442
更新日期：2017-01-01 00:00:00
abstract：:GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to s...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-00752-x
更新日期：2021-01-01 00:00:00
abstract：:Declarative memory, the conscious recollection of past experiences, is known to involve the hippocampus. Now a study of amnesic patients shows that hippocampus-dependent learning can occur in the absence of conscious awareness. ...
journal_title：Nature neuroscience
pub_type： 评论,新闻
doi：10.1038/12137
更新日期：1999-09-01 00:00:00
abstract：:Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4517
更新日期：2017-04-01 00:00:00
abstract：:Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2624
更新日期：2010-10-01 00:00:00
abstract：:Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in est...
journal_title：Nature neuroscience
pub_type： 评论,新闻
doi：10.1038/nn0910-1039
更新日期：2010-09-01 00:00:00
abstract：:The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic regulation and nongenomic mechanisms. A key result of stress is structural remodeling of neural architecture, which may be a si...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4086
更新日期：2015-10-01 00:00:00
abstract：:Illusions that produce perceptual suppression despite constant retinal input are used to manipulate visual consciousness. Here we report on a powerful variant of existing techniques, continuous flash suppression. Distinct images flashed successively at approximately 10 Hz into one eye reliably suppress an image presen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1500
更新日期：2005-08-01 00:00:00
abstract：:Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4116
更新日期：2015-11-01 00:00:00
abstract：:Voltage-gated sodium channels (Na(V)) are critical for initiation of action potentials. Heterozygous loss-of-function mutations in Na(V)1.1 channels cause severe myoclonic epilepsy in infancy (SMEI). Homozygous null Scn1a-/- mice developed ataxia and died on postnatal day (P) 15 but could be sustained to P17.5 with ma...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1754
更新日期：2006-09-01 00:00:00
abstract：:Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2239
更新日期：2009-01-01 00:00:00
abstract：:Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0227-9
更新日期：2018-10-01 00:00:00
abstract：:Axonal degeneration is important during development but has not been thought to function in the intact mature nervous system. Here, we provide evidence that degeneration of adult axons occurs in the intact rodent brain through a p75 neurotrophin receptor (p75NTR)- and myelin-dependent mechanism. Specifically, we show ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2513
更新日期：2010-05-01 00:00:00
abstract：:Human behavior is mostly composed of habitual actions that require little conscious control. Such actions may become invalid if the environment changes, at which point individuals need to switch behavior by overcoming habitual actions that are otherwise triggered automatically. It is unknown how the brain controls thi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1830
更新日期：2007-02-01 00:00:00
abstract：:Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic po...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2634
更新日期：2010-10-01 00:00:00
abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0119-z
更新日期：2018-05-01 00:00:00
abstract：:Over the past two centuries, prevalent models of energy and glucose homeostasis have emerged from careful anatomical descriptions in tandem with an understanding of cellular physiology. More recent technological advances have culminated in the identification of peripheral and central factors that influence neural circ...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3217
更新日期：2012-10-01 00:00:00
abstract：:An object viewed from different angles can be recognized and distinguished from similar distractors after the viewer has had experience watching it rotate. It has been assumed that as an observer watches the rotation, separate representations of individual views become associated with one another. However, we show her...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1600
更新日期：2005-12-01 00:00:00
abstract：:Parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss of dopaminergic neurons innervating the striatum. As striatal dopamine levels fall, striatal acetylcholine release rises, exacerbating motor symptoms. This adaptation is commonly attributed to the loss of interneuronal regulation b...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1700
更新日期：2006-06-01 00:00:00
abstract：:Over the last 10 years, optogenetics has become widespread in neuroscience for the study of how specific cell types contribute to brain functions and brain disorder states. The full impact of optogenetics will emerge only when other toolsets mature, including neural connectivity and cell phenotyping tools and neural r...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章
doi：10.1038/nn.4094
更新日期：2015-09-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-019-0546-5
更新日期：2019-12-01 00:00:00
abstract：:Sensory neural systems use spatiotemporal coding mechanisms to represent stimuli. These time-varying response patterns sometimes outlast the stimulus. Can the temporal structure of a stimulus interfere with, or even disrupt, the spatiotemporal structure of the neural representation? We investigated this potential conf...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1559
更新日期：2005-11-01 00:00:00
