Abstract:
:Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses, but how information flows between these reciprocally connected structures to coordinate behavior is unknown. We recorded neuronal activity from the BLA and PL while rats performed a task wherein competing shock- and sucrose-predictive cues were simultaneously presented. The correlated firing primarily displayed a BLA→PL directionality during the shock-associated cue. Furthermore, BLA neurons optogenetically identified as projecting to PL more accurately predicted behavioral responses during competition than unidentified BLA neurons. Finally photostimulation of the BLA→PL projection increased freezing, whereas both chemogenetic and optogenetic inhibition reduced freezing. Therefore, the BLA→PL circuit is critical in governing the selection of behavioral responses in the face of competing signals.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Burgos-Robles A,Kimchi EY,Izadmehr EM,Porzenheim MJ,Ramos-Guasp WA,Nieh EH,Felix-Ortiz AC,Namburi P,Leppla CA,Presbrey KN,Anandalingam KK,Pagan-Rivera PA,Anahtar M,Beyeler A,Tye KMdoi
10.1038/nn.4553subject
Has Abstractpub_date
2017-06-01 00:00:00pages
824-835issue
6eissn
1097-6256issn
1546-1726pii
nn.4553journal_volume
20pub_type
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