Abstract:
:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors including aggression are mediated by hardwired brain circuitries that specialize in processing certain sensory inputs to trigger stereotyped motor outputs. They further suggest that instinctive behaviors are influenced by an animal's internal state and past experiences. Following this conceptual framework, here we review our current understanding regarding the neural substrates underlying aggression generation, highlighting an evolutionarily conserved 'core aggression circuit' composed of four subcortical regions. We further discuss the neural mechanisms that support changes in aggression based on the animal's internal state. We aim to provide an overview of features of aggression and the relevant neural substrates across species, highlighting findings in rodents, primates and songbirds.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Lischinsky JE,Lin Ddoi
10.1038/s41593-020-00715-2subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1317-1328issue
11eissn
1097-6256issn
1546-1726pii
10.1038/s41593-020-00715-2journal_volume
23pub_type
杂志文章,评审abstract::Neuroscience seeks to understand how neural circuits lead to behavior. However, the gap between circuits and behavior is too wide. An intermediate level is one of neural computations, which occur in individual neurons and populations of neurons. Some computations seem to be canonical: repeated and combined in differen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3043
更新日期:2012-03-27 00:00:00
abstract::In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0183-4
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abstract::A single neurotransmitter elicits diverse physiological responses through activation of multiple receptor subtypes and/or heterosynaptic interactions involving distinct synaptic targets. We found that a typical excitatory transmitter released from the climbing fiber (CF) in the cerebellar cortex not only excited Purki...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/75718
更新日期:2000-06-01 00:00:00
abstract::Motion and stereoscopic depth are fundamental parameters of the structural analysis of visual scenes. Because they are defined by a difference in object position, either over time or across the eyes, a common neural machinery may be used for encoding these attributes. To examine this idea, we analyzed responses of bin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/87462
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abstract::Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopam...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1438
更新日期:2005-05-01 00:00:00
abstract::Protein-coding de novo mutations (DNMs) are significant risk factors in many neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs has thus far been shown to be modest. We analyzed DNMs from 1,695 SCZ-affected trios and 1,077 published SCZ-affected trios to better understand the contribut...
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1509
更新日期:2005-08-01 00:00:00
abstract::Temporal regulation of embryonic neurogenesis is controlled by hypostable transcription factors. The mechanism of the process is unclear. Here we show that the RNase III Drosha and DGCR8 (also known as Pasha), key components of the microRNA (miRNA) microprocessor, have important functions in mouse neurogenesis. Loss o...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3139
更新日期:2012-06-17 00:00:00
abstract::Dendritic spikes signal synaptic integration at remote apical dendritic sites in neocortical pyramidal neurons in vitro. Do dendritic spikes have a salient signaling role under in vivo conditions, where neocortical pyramidal neurons are bombarded with synaptic input? In the present study, levels of synaptic conductanc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1305
更新日期:2004-09-01 00:00:00
abstract::Although de novo missense mutations have been predicted to account for more cases of autism than gene-truncating mutations, most research has focused on the latter. We identified the properties of de novo missense mutations in patients with neurodevelopmental disorders (NDDs) and highlight 35 genes with excess missens...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4589
更新日期:2017-08-01 00:00:00
abstract::The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-0677-8
更新日期:2020-10-01 00:00:00
abstract::Neuronal differentiation is accomplished through cascades of intrinsic genetic factors initiated in neuronal progenitors by external gradients of morphogens. Activity has been thought to be important only late in development, but recent evidence suggests that activity also regulates early neuronal differentiation. Act...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2582
更新日期:2010-08-01 00:00:00
abstract::Multiple protein kinase C (PKC) isozymes are present in neurons, where they regulate a variety of cellular functions. Due to the lack of specific PKC isozyme inhibitors, it remains unknown how PKC acts on its selective target(s) and achieves its specific actions. Here we show that a PKC binding protein, enigma homolog...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1041
更新日期:2003-05-01 00:00:00
abstract::Shared neural variability is ubiquitous in cortical populations. While this variability is presumed to arise from overlapping synaptic input, its precise relationship to local circuit architecture remains unclear. We combine computational models and in vivo recordings to study the relationship between the spatial stru...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4433
更新日期:2017-01-01 00:00:00
abstract::In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAM...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2289
更新日期:2009-04-01 00:00:00
abstract::Social behaviors recruit multiple cognitive operations that require interactions between cortical and subcortical brain regions. Interareal synchrony may facilitate such interactions between cortical and subcortical neural populations. However, it remains unknown how neurons from different nodes in the social brain ne...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-0593-y
更新日期:2020-04-01 00:00:00
abstract::We report a systematic relationship between sound-frequency tuning and sensitivity to interaural time delays for neurons in the midbrain nucleus of the inferior colliculus; neurons with relatively low best frequencies (BFs) showed response peaks at long delays, whereas neurons with relatively high BFs showed response ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/86049
更新日期:2001-04-01 00:00:00
abstract::Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3604
更新日期:2014-03-01 00:00:00
abstract::High and low spatial frequency information in visual images is processed by distinct neural channels. Using event-related functional magnetic resonance imaging (fMRI) in humans, we show dissociable roles of such visual channels for processing faces and emotional fearful expressions. Neural responses in fusiform cortex...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1057
更新日期:2003-06-01 00:00:00
abstract::The usefulness of genetically encoded probes for optical monitoring of neuronal activity and brain circuits would be greatly advanced by the generation of multiple indicators with non-overlapping color spectra. Most existing indicators are derived from or spectrally convergent on GFP. We generated a bright, red, pH-se...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3126
更新日期:2012-05-27 00:00:00
abstract::Class I histone deacetylases (HDACs) Hdac1 and Hdac2 can associate together in protein complexes with transcriptional factors such as methyl-CpG-binding protein 2 (MeCP2). Given their high degree of sequence identity, we examined whether Hdac1 and Hdac2 were functionally redundant in mature mouse brain. We demonstrate...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4395
更新日期:2016-11-01 00:00:00
abstract::Using magnetoencephalography (MEG), we compared the processing of sinusoidal tones in the auditory cortex of 12 non-musicians, 12 professional musicians and 13 amateur musicians. We found neurophysiological and anatomical differences between groups. In professional musicians as compared to non-musicians, the activity ...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/nn871
更新日期:2002-07-01 00:00:00
abstract::Neurons in many species have large receptive fields that are selective for specific optic flow fields. Here, we studied the neural mechanisms underlying flow field selectivity in lobula plate tangential cells (LPTCs) of the blowfly. Among these cells, the H2 cell responds preferentially to visual stimuli approximating...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1769
更新日期:2006-10-01 00:00:00
abstract::By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and 1,077 trios, we identified a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10(-9)). We found only two heterozygous LoF variants in 45,376 exomes fro...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4267
更新日期:2016-04-01 00:00:00
abstract::Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis can be highly time consuming. In motor control studies, humans or other...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0209-y
更新日期:2018-09-01 00:00:00
abstract::The growth of neurites (axon and dendrite) should be appropriately regulated by their interactions in the development of nervous systems where a myriad of neurons and their neurites are tightly packed. We show here that mammalian seven-pass transmembrane cadherins Celsr2 and Celsr3 are activated by their homophilic in...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1933
更新日期:2007-08-01 00:00:00
abstract::Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked end...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1126
更新日期:2003-10-01 00:00:00
abstract::Long-term synaptic changes, which are essential for learning and memory, are dependent on homeostatic mechanisms that stabilize neural activity. Homeostatic responses have also been implicated in pathological conditions, including nicotine addiction. Although multiple homeostatic pathways have been described, little i...
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pub_type: 杂志文章
doi:10.1038/nn.2969
更新日期:2011-11-13 00:00:00
abstract::To determine the number of open Ca(2+) channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca(2+) imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca(2+) channels triggered tr...
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doi:10.1038/nn.2461
更新日期:2010-01-01 00:00:00