Intracellular zinc inhibits KCC2 transporter activity.

Abstract:

:We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose deprivation attenuated KCC2 activity in a Zn(2+)-dependent manner. The link between Zn(2+) and KCC2 activity provides a previously unknown target for neuroprotection and may be important in activity-dependent regulation of inhibitory synaptic transmission.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Hershfinkel M,Kandler K,Knoch ME,Dagan-Rabin M,Aras MA,Abramovitch-Dahan C,Sekler I,Aizenman E

doi

10.1038/nn.2316

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

725-7

issue

6

eissn

1097-6256

issn

1546-1726

pii

nn.2316

journal_volume

12

pub_type

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