Abstract：
:Many of the behavioral consequences of stress are mediated by the activation of the glucocorticoid receptor by stress-induced high levels of glucocorticoid hormones. To explore the molecular mechanisms of these effects, we combined in vivo and in vitro approaches. We analyzed mice carrying a brain-specific mutation (GR(NesCre)) in the glucocorticoid receptor gene (GR, also called Nr3c1) and cell lines that either express endogenous glucocorticoid receptor or carry a constitutively active form of the receptor (DeltaGR) that can be transiently induced. In the hippocampus of the wild-type [corrected] mice after stress, as well as in the cell lines, activation of glucocorticoid receptors greatly increased the expression and enzymatic activity of proteins in the MAPK signaling pathway and led to an increase in the levels of both Egr-1 mRNA and protein. In parallel, inhibition of the MAPK pathway within the hippocampus abolished the increase in contextual fear conditioning induced by glucocorticoids. The present results provide a molecular mechanism for the stress-related effects of glucocorticoids on fear memories.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Revest JM,Di Blasi F,Kitchener P,Rougé-Pont F,Desmedt A,Turiault M,Tronche F,Piazza PVdoi
10.1038/nn1441subject
Has Abstractpub_date
2005-05-01 00:00:00pages
664-72issue
5eissn
1097-6256issn
1546-1726pii
nn1441journal_volume
8pub_type
杂志文章abstract：:In this report we describe how common brain networks within the medial frontal cortex (MFC) facilitate adaptive behavioral control in rodents and humans. We demonstrate that after errors, low-frequency oscillations below 12 Hz are modulated over the midfrontal cortex in humans and within the prelimbic and anterior cin...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3549
更新日期：2013-12-01 00:00:00
abstract：:Sensory pathways are typically studied by starting at receptor neurons and following postsynaptic neurons into the brain. However, this leads to a bias in analyses of activity toward the earliest layers of processing. Here, we present new methods for volumetric neural imaging with precise across-brain registration to ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-00743-y
更新日期：2021-01-01 00:00:00
abstract：:Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4442
更新日期：2017-01-01 00:00:00
abstract：:Parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss of dopaminergic neurons innervating the striatum. As striatal dopamine levels fall, striatal acetylcholine release rises, exacerbating motor symptoms. This adaptation is commonly attributed to the loss of interneuronal regulation b...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1700
更新日期：2006-06-01 00:00:00
abstract：:In the version of this article initially published online, the accession code was given as GSE1000333. The correct code is GSE100033. The error has been corrected in the print, HTML and PDF versions of the article. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0114-4
更新日期：2018-07-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-020-0595-9
更新日期：2020-02-01 00:00:00
abstract：:What neural activity in motor cortex represents and how it controls ongoing movement remain unclear. Suggestions that cortex generates low-level muscle control are discredited by correlations with higher-level parameters of hand movement, but no coherent alternative exists. I argue that the view of low-level control i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/73964
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2449
更新日期：2010-01-01 00:00:00
abstract：:Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3911
更新日期：2015-02-01 00:00:00
abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1289
更新日期：2004-08-01 00:00:00
abstract：:Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn884
更新日期：2002-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/13197
更新日期：1999-10-01 00:00:00
abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0584-z
更新日期：2020-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1815
更新日期：2007-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1553
更新日期：2005-10-01 00:00:00
abstract：:Individuals' risk attitudes are known to guide choices about uncertain options. However, in the presence of others' decisions, these choices can be swayed and manifest as riskier or safer behavior than one would express alone. To test the mechanisms underlying effective social 'nudges' in human decision-making, we use...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4022
更新日期：2015-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4393
更新日期：2016-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0255-5
更新日期：2018-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3862
更新日期：2014-12-01 00:00:00
abstract：:The music faculty is not a monolithic entity that a person either has or does not. Rather, it comprises a set of neurally isolable processing components, each having the potential to be specialized for music. Here we propose a functional architecture for music processing that captures the typical properties of modular...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn1083
更新日期：2003-07-01 00:00:00
abstract：:Exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (NAc)-based behaviors, yet produce very different adaptations at NAc excitatory synapses. In an effort to explain this paradox, we found that both drugs induced NMDA receptor-containing, AMPA receptor-silent excitatory synapses, albeit ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4313
更新日期：2016-07-01 00:00:00
abstract：:In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0111-7
更新日期：2018-06-01 00:00:00
abstract：:Evaluating social others requires processing complex information. Nevertheless, we can rapidly form an opinion of an individual during an initial encounter. Moreover, people can vary in these opinions, even though the same information is provided. We investigated the brain mechanisms that give rise to the impressions ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2278
更新日期：2009-04-01 00:00:00
abstract：:Temporal and quantitative relations between excitatory and inhibitory inputs in the cortex are central to its activity, yet they remain poorly understood. In particular, a controversy exists regarding the extent of correlation between cortical excitation and inhibition. Using simultaneous intracellular recordings in p...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2105
更新日期：2008-05-01 00:00:00
abstract：:The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental q...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4300
更新日期：2016-06-01 00:00:00
abstract：:The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which is characterized by changes in the tau protein and in the cleaved fragments of the amyloid precursor protein (APP). We used a high-resolution functional magnetic resonance imaging (fMRI) variant that can map metabolic defects i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3606
更新日期：2014-02-01 00:00:00
abstract：:We argue that there will be no single (genetic or cognitive) cause for the diverse symptoms defining autism. We present recent evidence of behavioral fractionation of social impairment, communication difficulties and rigid and repetitive behaviors. Twin data suggest largely nonoverlapping genes acting on each of these...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn1770
更新日期：2006-10-01 00:00:00
abstract：:Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well as the reward from relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry. In this Review,...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3811
更新日期：2014-10-01 00:00:00
abstract：:Motion and stereoscopic depth are fundamental parameters of the structural analysis of visual scenes. Because they are defined by a difference in object position, either over time or across the eyes, a common neural machinery may be used for encoding these attributes. To examine this idea, we analyzed responses of bin...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/87462
更新日期：2001-05-01 00:00:00
abstract：:In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/1609
更新日期：1998-09-01 00:00:00
