Abstract:
:Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein synthesis was altered in the hippocampus and that hippocampus-dependent memory was impaired. Notably, chronic treatment with a negative allosteric modulator of mGluR5 reversed the cognitive deficit.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Tian D,Stoppel LJ,Heynen AJ,Lindemann L,Jaeschke G,Mills AA,Bear MFdoi
10.1038/nn.3911subject
Has Abstractpub_date
2015-02-01 00:00:00pages
182-4issue
2eissn
1097-6256issn
1546-1726pii
nn.3911journal_volume
18pub_type
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