Abstract:
:In the version of this article initially published online, the accession code was given as GSE1000333. The correct code is GSE100033. The error has been corrected in the print, HTML and PDF versions of the article.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Preissl S,Fang R,Huang H,Zhao Y,Raviram R,Gorkin DU,Zhang Y,Sos BC,Afzal V,Dickel DE,Kuan S,Visel A,Pennacchio LA,Zhang K,Ren Bdoi
10.1038/s41593-018-0114-4subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1015issue
7eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0114-4journal_volume
21pub_type
已发布勘误abstract::Although de novo missense mutations have been predicted to account for more cases of autism than gene-truncating mutations, most research has focused on the latter. We identified the properties of de novo missense mutations in patients with neurodevelopmental disorders (NDDs) and highlight 35 genes with excess missens...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4589
更新日期:2017-08-01 00:00:00
abstract::Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well as the reward from relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry. In this Review,...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3811
更新日期:2014-10-01 00:00:00
abstract::We demonstrate a form of long-term depression (LTD) in the perirhinal cortex that relies on interaction between different glutamate receptors. Group II metabotropic glutamate (mGlu) receptors facilitated group I mGlu receptor-mediated increases in intracellular calcium. This facilitation plus NMDA receptor activation ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/72093
更新日期:2000-02-01 00:00:00
abstract::The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3348
更新日期:2013-04-01 00:00:00
abstract::Age-related decreases in neural function result in part from alterations in synapses. To identify molecular defects that lead to such changes, we focused on the outer retina, in which synapses are markedly altered in old rodents and humans. We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3772
更新日期:2014-09-01 00:00:00
abstract::The dorsal root ganglia (DRG) contain a variety of mechanoreceptors, but no molecular markers uniquely identify specific mechanoreceptor subtypes. We have used DNA microarrays and subtracted cDNA libraries to isolate genes that are specifically expressed by one type of mouse mechanoreceptor. The T-type calcium channel...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1076
更新日期:2003-07-01 00:00:00
abstract::The processing of synaptic potentials by neuronal dendrites depends on both their passive cable properties and active voltage-gated channels, which can generate complex effects as a result of their nonlinear properties. We characterized the actions of HCN (hyperpolarization-activated cyclic nucleotide-gated cation) ch...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2307
更新日期:2009-05-01 00:00:00
abstract::The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2540
更新日期:2010-06-01 00:00:00
abstract::Tau protein can transfer between neurons transneuronally and trans-synaptically, which is thought to explain the progressive spread of tauopathy observed in the brain of patients with Alzheimer's disease. Here we show that physiological tau released from donor cells can transfer to recipient cells via the medium, sugg...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4328
更新日期:2016-08-01 00:00:00
abstract::Remembering a past experience can, surprisingly, cause forgetting. Forgetting arises when other competing traces interfere with retrieval and inhibitory control mechanisms are engaged to suppress the distraction they cause. This form of forgetting is considered to be adaptive because it reduces future interference. Th...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3973
更新日期:2015-04-01 00:00:00
abstract::Ca(v)2.1 channels, which mediate P/Q-type Ca2+ currents, undergo Ca2+/calmodulin (CaM)-dependent inactivation and facilitation that can significantly alter synaptic efficacy. Here we report that the neuronal Ca2+-binding protein 1 (CaBP1) modulates Ca(v)2.1 channels in a manner that is markedly different from modulati...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn805
更新日期:2002-03-01 00:00:00
abstract::Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca2+ imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0254-6
更新日期:2018-11-01 00:00:00
abstract::The ventral intraparietal area (VIP) receives converging inputs from visual, somatosensory, auditory and vestibular systems that use diverse reference frames to encode sensory information. A key issue is how VIP combines those inputs together. We mapped the visual and tactile receptive fields of multimodal VIP neurons...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1480
更新日期:2005-07-01 00:00:00
abstract::Learning to adapt to a complex and fluctuating environment requires the ability to adjust neural representations of sensory stimuli. Through pattern completion processes, cortical networks can reconstruct familiar patterns from degraded input patterns, whereas pattern separation processes allow discrimination of even ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2966
更新日期:2011-11-20 00:00:00
abstract::The identity of specific cell types in the nervous system is defined by the expression of neuron type-specific gene batteries. How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades. However, comparatively little is known about how g...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3731
更新日期:2014-07-01 00:00:00
abstract::Glycine receptors (GlyRs), together with GABA(A) and nicotinic acetylcholine (ACh) receptors, form part of the ligand-activated ion channel superfamily and regulate the excitability of the mammalian brain stem and spinal cord. Here we report that the ability of the neurotransmitter glycine to gate recombinant and nati...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1095
更新日期:2003-08-01 00:00:00
abstract::Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3207
更新日期:2012-10-01 00:00:00
abstract::We report on two brain-damaged subjects who exhibit the uncommon pattern of loss of object color knowledge, but spared color perception and naming. The subject P.C.O., as in previously reported patients, is also impaired in processing other perceptual and functional properties of objects. I.O.C., in contrast, is the f...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/88497
更新日期:2001-06-01 00:00:00
abstract::Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0119-z
更新日期:2018-05-01 00:00:00
abstract::In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn806
更新日期:2002-03-01 00:00:00
abstract::Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here we demonstrate a central role for capillary endothelial cells in sensing neural activity and communicating it to upstream arterioles in the form of an el...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4533
更新日期:2017-05-01 00:00:00
abstract::GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to s...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00752-x
更新日期:2021-01-01 00:00:00
abstract::Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2135
更新日期:2008-07-01 00:00:00
abstract::A single neurotransmitter elicits diverse physiological responses through activation of multiple receptor subtypes and/or heterosynaptic interactions involving distinct synaptic targets. We found that a typical excitatory transmitter released from the climbing fiber (CF) in the cerebellar cortex not only excited Purki...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/75718
更新日期:2000-06-01 00:00:00
abstract::Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2076
更新日期:2008-04-01 00:00:00
abstract::Imaging, from magnetic resonance imaging (MRI) to localization of specific macromolecules by microscopies, has been one of the driving forces behind neuroinformatics efforts of the past decade. Many web-accessible resources have been created, ranging from simple data collections to highly structured databases. Althoug...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1229
更新日期:2004-05-01 00:00:00
abstract::Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/85191
更新日期:2001-03-01 00:00:00
abstract::An afterimage looks larger when one fixates on a distant than on a closer surface. We show that the retinotopic activity in the primary visual cortex (V1) associated with viewing an afterimage is modulated by perceived size, even when the size of the retinal image remains constant. This suggests that V1 has an importa...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3069
更新日期:2012-03-11 00:00:00
abstract::Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. The voltage-gated proton channel Hv1 enables NOX function by compensating cellular loss of electrons with protons. Accordingly...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3059
更新日期:2012-03-04 00:00:00
abstract::The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hy...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2763
更新日期:2011-04-01 00:00:00