A neural mechanism of first impressions.

Abstract:

:Evaluating social others requires processing complex information. Nevertheless, we can rapidly form an opinion of an individual during an initial encounter. Moreover, people can vary in these opinions, even though the same information is provided. We investigated the brain mechanisms that give rise to the impressions that are formed on meeting a new person. Neuroimaging revealed that responses in the amygdala and the posterior cingulate cortex (PCC) were stronger while encoding social information that was consistent, relative to inconsistent, with subsequent evaluations. In addition, these responses scaled parametrically with the strength of evaluations. These findings provide evidence for encoding differences on the basis of subsequent evaluations, suggesting that the amygdala and PCC are important for forming first impressions.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Schiller D,Freeman JB,Mitchell JP,Uleman JS,Phelps EA

doi

10.1038/nn.2278

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

508-14

issue

4

eissn

1097-6256

issn

1546-1726

pii

nn.2278

journal_volume

12

pub_type

杂志文章
  • Cell-specific pallidal intervention induces long-lasting motor recovery in dopamine-depleted mice.

    abstract::The identification of distinct cell types in the basal ganglia has been critical to our understanding of basal ganglia function and the treatment of neurological disorders. The external globus pallidus (GPe) is a key contributor to motor suppressing pathways in the basal ganglia, yet its neuronal heterogeneity has rem...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.4559

    authors: Mastro KJ,Zitelli KT,Willard AM,Leblanc KH,Kravitz AV,Gittis AH

    更新日期:2017-06-01 00:00:00

  • Broadly tuned and respiration-independent inhibition in the olfactory bulb of awake mice.

    abstract::Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensembl...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3669

    authors: Cazakoff BN,Lau BY,Crump KL,Demmer HS,Shea SD

    更新日期:2014-04-01 00:00:00

  • The organization of two new cortical interneuronal circuits.

    abstract::Deciphering the interneuronal circuitry is central to understanding brain functions, yet it remains a challenging task in neurobiology. Using simultaneous quadruple-octuple in vitro and dual in vivo whole-cell recordings, we found two previously unknown interneuronal circuits that link cortical layer 1-3 (L1-3) intern...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3305

    authors: Jiang X,Wang G,Lee AJ,Stornetta RL,Zhu JJ

    更新日期:2013-02-01 00:00:00

  • Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex.

    abstract::Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipol...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2816

    authors: Jossin Y,Cooper JA

    更新日期:2011-06-01 00:00:00

  • Functional consequences of animal-to-animal variation in circuit parameters.

    abstract::How different are the neuronal circuits for a given behavior across individual animals? To address this question, we measured multiple cellular and synaptic parameters in individual preparations to see how they correlated with circuit function, using neurons and synapses in the pyloric circuit of the stomatogastric ga...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2404

    authors: Goaillard JM,Taylor AL,Schulz DJ,Marder E

    更新日期:2009-11-01 00:00:00

  • RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels.

    abstract::The molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a previously unknown interaction between two components of the presynaptic active zone, RIM1 and voltage-dependent Ca2+ channels (VDCCs), th...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1904

    authors: Kiyonaka S,Wakamori M,Miki T,Uriu Y,Nonaka M,Bito H,Beedle AM,Mori E,Hara Y,De Waard M,Kanagawa M,Itakura M,Takahashi M,Campbell KP,Mori Y

    更新日期:2007-06-01 00:00:00

  • Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion.

    abstract::Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3911

    authors: Tian D,Stoppel LJ,Heynen AJ,Lindemann L,Jaeschke G,Mills AA,Bear MF

    更新日期:2015-02-01 00:00:00

  • Reward and motivation in pain and pain relief.

    abstract::Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well as the reward from relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry. In this Review,...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审

    doi:10.1038/nn.3811

    authors: Navratilova E,Porreca F

    更新日期:2014-10-01 00:00:00

  • Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex.

    abstract::The cerebral cortex has the ability to adapt to altered sensory inputs. In the visual cortex, a small lesion to the retina causes the deprived cortical region to become responsive to adjacent parts of the visual field. This extensive topographic remapping is assumed to be mediated by the rewiring of intracortical conn...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2181

    authors: Keck T,Mrsic-Flogel TD,Vaz Afonso M,Eysel UT,Bonhoeffer T,Hübener M

    更新日期:2008-10-01 00:00:00

  • State-dependent encoding of sound and behavioral meaning in a tertiary region of the ferret auditory cortex.

    abstract::In higher sensory cortices, there is a gradual transformation from sensation to perception and action. In the auditory system, this transformation is revealed by responses in the rostral ventral posterior auditory field (VPr), a tertiary area in the ferret auditory cortex, which shows long-term learning in trained com...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/s41593-018-0317-8

    authors: Elgueda D,Duque D,Radtke-Schuller S,Yin P,David SV,Shamma SA,Fritz JB

    更新日期:2019-03-01 00:00:00

  • Gaze bias both reflects and influences preference.

    abstract::Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1150

    authors: Shimojo S,Simion C,Shimojo E,Scheier C

    更新日期:2003-12-01 00:00:00

  • Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain.

    abstract::Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.4489

    authors: Kisler K,Nelson AR,Rege SV,Ramanathan A,Wang Y,Ahuja A,Lazic D,Tsai PS,Zhao Z,Zhou Y,Boas DA,Sakadžić S,Zlokovic BV

    更新日期:2017-03-01 00:00:00

  • Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h).

    abstract::Hippocampal long-term potentiation (LTP) induced by theta-burst pairing of Schaffer collateral inputs and postsynaptic firing is associated with localized increases in synaptic strength and dendritic excitability. Using the same protocol, we now demonstrate a decrease in cellular excitability that was blocked by the h...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1568

    authors: Fan Y,Fricker D,Brager DH,Chen X,Lu HC,Chitwood RA,Johnston D

    更新日期:2005-11-01 00:00:00

  • Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo.

    abstract::The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses of the cholinergic system. After release into the synaptic cleft, ACh is rapidly degraded by acetylcholinesterase (AChE). We have identified a mutation in the ache gene of the zebrafish, which abolishes ACh hydrolysis in ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn788

    authors: Behra M,Cousin X,Bertrand C,Vonesch JL,Biellmann D,Chatonnet A,Strähle U

    更新日期:2002-02-01 00:00:00

  • Heterogeneity of CNS myeloid cells and their roles in neurodegeneration.

    abstract::The diseased brain hosts a heterogeneous population of myeloid cells, including parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne monocytes. To date, the different types of brain myeloid cells have been discriminated solely on the basis of their localization, morphology and surface epito...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审

    doi:10.1038/nn.2923

    authors: Prinz M,Priller J,Sisodia SS,Ransohoff RM

    更新日期:2011-09-27 00:00:00

  • Classical and operant conditioning differentially modify the intrinsic properties of an identified neuron.

    abstract::A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1593

    authors: Lorenzetti FD,Mozzachiodi R,Baxter DA,Byrne JH

    更新日期:2006-01-01 00:00:00

  • A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.

    abstract::Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins syndrome (PTHS), a syndromic form of ASD caused by mutations in the TCF4 gene, but not the T...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/s41593-019-0578-x

    authors: Phan BN,Bohlen JF,Davis BA,Ye Z,Chen HY,Mayfield B,Sripathy SR,Cerceo Page S,Campbell MN,Smith HL,Gallop D,Kim H,Thaxton CL,Simon JM,Burke EE,Shin JH,Kennedy AJ,Sweatt JD,Philpot BD,Jaffe AE,Maher BJ

    更新日期:2020-03-01 00:00:00

  • Temporal plasticity in the primary auditory cortex induced by operant perceptual learning.

    abstract::Processing of rapidly successive acoustic stimuli can be markedly improved by sensory training. To investigate the cortical mechanisms underlying such temporal plasticity, we trained rats in a 'sound maze' in which navigation using only auditory cues led to a target location paired with food reward. In this task, the ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1293

    authors: Bao S,Chang EF,Woods J,Merzenich MM

    更新日期:2004-09-01 00:00:00

  • Switching from automatic to controlled action by monkey medial frontal cortex.

    abstract::Human behavior is mostly composed of habitual actions that require little conscious control. Such actions may become invalid if the environment changes, at which point individuals need to switch behavior by overcoming habitual actions that are otherwise triggered automatically. It is unknown how the brain controls thi...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1830

    authors: Isoda M,Hikosaka O

    更新日期:2007-02-01 00:00:00

  • Neural correlates of prickle sensation: a percept-related fMRI study.

    abstract::The painful sensations produced by a laceration, freeze, burn, muscle strain or internal injury are readily distinguishable because each is characterized by a particular sensory quality such as sharp, aching, burning or prickling. We propose that there are specific neural correlates of each pain quality, and here we u...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn955

    authors: Davis KD,Pope GE,Crawley AP,Mikulis DJ

    更新日期:2002-11-01 00:00:00

  • Retinoid X receptor gamma signaling accelerates CNS remyelination.

    abstract::The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We generated a comprehensive transcriptional profile of the separate stages of spontaneous remyelination that follow focal demyelination in the rat CNS and found that transcripts that encode the retinoid acid receptor RXR-γ were diffe...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2702

    authors: Huang JK,Jarjour AA,Nait Oumesmar B,Kerninon C,Williams A,Krezel W,Kagechika H,Bauer J,Zhao C,Baron-Van Evercooren A,Chambon P,Ffrench-Constant C,Franklin RJM

    更新日期:2011-01-01 00:00:00

  • Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex.

    abstract::Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3051

    authors: Gentet LJ,Kremer Y,Taniguchi H,Huang ZJ,Staiger JF,Petersen CC

    更新日期:2012-02-26 00:00:00

  • Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors.

    abstract::In the postnatal subventricular zone (SVZ), local cues or signaling molecules released from neuroblasts limit the proliferation of glial fibrillary acidic protein (GFAP)-expressing progenitors thought to be stem cells. However, signals between SVZ cells have not been identified. We show that depolarization of neurobla...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1522

    authors: Liu X,Wang Q,Haydar TF,Bordey A

    更新日期:2005-09-01 00:00:00

  • Tbr1 instructs laminar patterning of retinal ganglion cell dendrites.

    abstract::Visual information is delivered to the brain by >40 types of retinal ganglion cells (RGCs). Diversity in this representation arises within the inner plexiform layer (IPL), where dendrites of each RGC type are restricted to specific sublaminae, limiting the interneuronal types that can innervate them. How such dendriti...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/s41593-018-0127-z

    authors: Liu J,Reggiani JDS,Laboulaye MA,Pandey S,Chen B,Rubenstein JLR,Krishnaswamy A,Sanes JR

    更新日期:2018-05-01 00:00:00

  • Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation.

    abstract::Several ion channels are thought to be directly modulated by nitric oxide (NO), but the molecular basis of this regulation is unclear. Here we show that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO. Site-directed mutagenesis identified a critical cys...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/71090

    authors: Choi YB,Tenneti L,Le DA,Ortiz J,Bai G,Chen HS,Lipton SA

    更新日期:2000-01-01 00:00:00

  • A T-type calcium channel required for normal function of a mammalian mechanoreceptor.

    abstract::The dorsal root ganglia (DRG) contain a variety of mechanoreceptors, but no molecular markers uniquely identify specific mechanoreceptor subtypes. We have used DNA microarrays and subtracted cDNA libraries to isolate genes that are specifically expressed by one type of mouse mechanoreceptor. The T-type calcium channel...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1076

    authors: Shin JB,Martinez-Salgado C,Heppenstall PA,Lewin GR

    更新日期:2003-07-01 00:00:00

  • Representation of body identity and body actions in extrastriate body area and ventral premotor cortex.

    abstract::Although inherently linked, body form and body action may be represented in separate neural substrates. Using repetitive transcranial magnetic stimulation in healthy individuals, we show that interference with the extrastriate body area impairs the discrimination of bodily forms, and interference with the ventral prem...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1815

    authors: Urgesi C,Candidi M,Ionta S,Aglioti SM

    更新日期:2007-01-01 00:00:00

  • A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory.

    abstract::Uncovering the functional relationship between temporal lobe amnesia and diencephalic amnesia depends on determining the role of the fornix, the major interlinking fiber tract. In this study relating fornix volume with memory, we made magnetic resonance imaging-based volume estimates of 13 brain structures in 38 indiv...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2149

    authors: Tsivilis D,Vann SD,Denby C,Roberts N,Mayes AR,Montaldi D,Aggleton JP

    更新日期:2008-07-01 00:00:00

  • Thalamic functions in distributed cognitive control.

    abstract::Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审

    doi:10.1038/s41593-017-0020-1

    authors: Halassa MM,Kastner S

    更新日期:2017-12-01 00:00:00

  • Neuronal activity modifies the chromatin accessibility landscape in the adult brain.

    abstract::Neuronal activity-induced gene expression modulates the function and plasticity of the nervous system. It is unknown whether and to what extent neuronal activity may trigger changes in chromatin accessibility, a major mode of epigenetic regulation of gene expression. Here we compared chromatin accessibility landscapes...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.4494

    authors: Su Y,Shin J,Zhong C,Wang S,Roychowdhury P,Lim J,Kim D,Ming GL,Song H

    更新日期:2017-03-01 00:00:00