Gaze bias both reflects and influences preference.

abstract：:Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs...

journal_title：Nature neuroscience

authors： Emes RD,Pocklington AJ,Anderson CN,Bayes A,Collins MO,Vickers CA,Croning MD,Malik BR,Choudhary JS,Armstrong JD,Grant SG

更新日期：2008-07-01 00:00:00

abstract：:Dendritic spines are motile structures that contain high concentrations of filamentous actin. Using hippocampal neurons expressing fluorescent actin and the method of fluorescence recovery after photobleaching, we found that 85 +/- 2% of actin in the spine was dynamic, with a turnover time of 44.2 +/- 4.0 s. The rapid...

journal_title：Nature neuroscience

authors： Star EN,Kwiatkowski DJ,Murthy VN

更新日期：2002-03-01 00:00:00

abstract：:Experience-dependent plasticity in adult visual cortex is believed to have important roles in visual coding and perceptual learning. Here we show that repeated stimulation with movies of natural scenes induces a rapid improvement in response reliability in cat visual cortex, whereas stimulation with white noise or fla...

journal_title：Nature neuroscience

authors： Yao H,Shi L,Han F,Gao H,Dan Y

更新日期：2007-06-01 00:00:00

abstract：:We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...

journal_title：Nature neuroscience

authors： Iftinca M,Hamid J,Chen L,Varela D,Tadayonnejad R,Altier C,Turner RW,Zamponi GW

更新日期：2007-07-01 00:00:00

abstract：:Accurate optical reporting of electrical activity in genetically defined neuronal populations is a long-standing goal in neuroscience. We developed Accelerated Sensor of Action Potentials 1 (ASAP1), a voltage sensor design in which a circularly permuted green fluorescent protein is inserted in an extracellular loop of...

journal_title：Nature neuroscience

authors： St-Pierre F,Marshall JD,Yang Y,Gong Y,Schnitzer MJ,Lin MZ

更新日期：2014-06-01 00:00:00

abstract：:Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We rep...

journal_title：Nature neuroscience

authors： Yasuda H,Barth AL,Stellwagen D,Malenka RC

更新日期：2003-01-01 00:00:00

abstract：:What neural activity in motor cortex represents and how it controls ongoing movement remain unclear. Suggestions that cortex generates low-level muscle control are discredited by correlations with higher-level parameters of hand movement, but no coherent alternative exists. I argue that the view of low-level control i...

journal_title：Nature neuroscience

authors： Todorov E

更新日期：2000-04-01 00:00:00

abstract：:Understanding a sensory system implies the ability to predict responses to a variety of inputs from a common model. In the retina, this includes predicting how the integration of signals across visual space shapes the outputs of retinal ganglion cells. Existing models of this process generalize poorly to predict respo...

journal_title：Nature neuroscience

authors： Schwartz GW,Okawa H,Dunn FA,Morgan JL,Kerschensteiner D,Wong RO,Rieke F

更新日期：2012-11-01 00:00:00

abstract：:Central pattern generators (CPGs) are spinal neuronal networks required for locomotion. Glutamatergic neurons have been implicated as being important for intrinsic rhythm generation in the CPG and for the command signal for initiating locomotion, although this has not been demonstrated directly. We used a newly genera...

journal_title：Nature neuroscience

authors： Hägglund M,Borgius L,Dougherty KJ,Kiehn O

更新日期：2010-02-01 00:00:00

abstract：:We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the ...

journal_title：Nature neuroscience

authors： Leopold DA,O'Toole AJ,Vetter T,Blanz V

更新日期：2001-01-01 00:00:00

abstract：:In mammals, olfaction is often used to distinguish individuals on the basis of their unique odor types (genetically programmed body odors). Parental-offspring recognition behavior is mediated, in part, by learning and processing of different odor types and is crucial for reproductive success. Maternal recognition beha...

journal_title：Nature neuroscience

authors： Mak GK,Weiss S

更新日期：2010-06-01 00:00:00

abstract：:The balance between proliferation and apoptosis is critical for proper development of the nervous system. Yet, little is known about molecules that regulate apoptosis of proliferative neurons. Here we identify a soluble, secreted form of CPG15 expressed in embryonic rat brain regions undergoing rapid proliferation and...

journal_title：Nature neuroscience

authors： Putz U,Harwell C,Nedivi E

更新日期：2005-03-01 00:00:00

abstract：:Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...

journal_title：Nature neuroscience

authors： Fenselau H,Campbell JN,Verstegen AM,Madara JC,Xu J,Shah BP,Resch JM,Yang Z,Mandelblat-Cerf Y,Livneh Y,Lowell BB

更新日期：2017-01-01 00:00:00

abstract：:Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal ...

journal_title：Nature neuroscience

authors： Murray JD,Bernacchia A,Freedman DJ,Romo R,Wallis JD,Cai X,Padoa-Schioppa C,Pasternak T,Seo H,Lee D,Wang XJ

更新日期：2014-12-01 00:00:00

abstract：:Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...

journal_title：Nature neuroscience

authors： Halassa MM,Kastner S

更新日期：2017-12-01 00:00:00

abstract：:To define the role of the Raf serine/threonine kinases in nervous system development, we conditionally targeted B-Raf and C-Raf, two of the three known mammalian Raf homologs, using a mouse line expressing Cre recombinase driven by a nestin promoter. Targeting of B-Raf, but not C-Raf, markedly attenuated baseline phos...

journal_title：Nature neuroscience

authors： Zhong J,Li X,McNamee C,Chen AP,Baccarini M,Snider WD

更新日期：2007-05-01 00:00:00

abstract：:Motion and stereoscopic depth are fundamental parameters of the structural analysis of visual scenes. Because they are defined by a difference in object position, either over time or across the eyes, a common neural machinery may be used for encoding these attributes. To examine this idea, we analyzed responses of bin...

journal_title：Nature neuroscience

authors： Anzai A,Ohzawa I,Freeman RD

更新日期：2001-05-01 00:00:00

abstract：:Activity in the primary auditory cortex (A1) is essential for normal sound localization behavior, but previous studies of the spatial sensitivity of neurons in A1 have found broad spatial tuning. We tested the hypothesis that spatial tuning sharpens when an animal engages in an auditory task. Cats performed a task tha...

journal_title：Nature neuroscience

authors： Lee CC,Middlebrooks JC

更新日期：2011-01-01 00:00:00

abstract：:Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...

journal_title：Nature neuroscience

authors： Evers DM,Matta JA,Hoe HS,Zarkowsky D,Lee SH,Isaac JT,Pak DT

更新日期：2010-10-01 00:00:00

abstract：:The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligoden...

journal_title：Nature neuroscience

authors： Goebbels S,Wieser GL,Pieper A,Spitzer S,Weege B,Yan K,Edgar JM,Yagensky O,Wichert SP,Agarwal A,Karram K,Renier N,Tessier-Lavigne M,Rossner MJ,Káradóttir RT,Nave KA

更新日期：2017-01-01 00:00:00

abstract：:Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional cross...

journal_title：Nature neuroscience

authors： Paredes I,Vieira JR,Shah B,Ramunno CF,Dyckow J,Adler H,Richter M,Schermann G,Giannakouri E,Schirmer L,Augustin HG,Ruiz de Almodóvar C

更新日期：2021-01-28 00:00:00

abstract：:Robust form perception and underlying neuronal mechanisms require generalized representation of object boundaries, independent of how they are defined. One visual ability essential for form perception is reconstruction of contours absent from the retinal image. Here we show that barn owls perceive subjective contours ...

journal_title：Nature neuroscience

authors： Nieder A,Wagner H

更新日期：1999-07-01 00:00:00

abstract：:Axonal degeneration is important during development but has not been thought to function in the intact mature nervous system. Here, we provide evidence that degeneration of adult axons occurs in the intact rodent brain through a p75 neurotrophin receptor (p75NTR)- and myelin-dependent mechanism. Specifically, we show ...

journal_title：Nature neuroscience

authors： Park KJ,Grosso CA,Aubert I,Kaplan DR,Miller FD

更新日期：2010-05-01 00:00:00

abstract：:Attention powerfully influences auditory perception, but little is understood about the mechanisms whereby attention sharpens responses to unattended sounds. We used high-resolution surface mapping techniques (using functional magnetic resonance imaging, fMRI) to examine activity in human auditory cortex during an int...

journal_title：Nature neuroscience

authors： Petkov CI,Kang X,Alho K,Bertrand O,Yund EW,Woods DL

更新日期：2004-06-01 00:00:00

abstract：:Synaptic stimulation activates signal transduction pathways, producing persistently active protein kinases. PKMzeta is a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks the N-terminal pseudosubstrate regulatory domain. Using a Pavlovian olfactory learning task in Drosop...

journal_title：Nature neuroscience

authors： Drier EA,Tello MK,Cowan M,Wu P,Blace N,Sacktor TC,Yin JC

更新日期：2002-04-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Marschallinger J,Iram T,Zardeneta M,Lee SE,Lehallier B,Haney MS,Pluvinage JV,Mathur V,Hahn O,Morgens DW,Kim J,Tevini J,Felder TK,Wolinski H,Bertozzi CR,Bassik MC,Aigner L,Wyss-Coray T

更新日期：2020-02-01 00:00:00

abstract：:Imaging, from magnetic resonance imaging (MRI) to localization of specific macromolecules by microscopies, has been one of the driving forces behind neuroinformatics efforts of the past decade. Many web-accessible resources have been created, ranging from simple data collections to highly structured databases. Althoug...

journal_title：Nature neuroscience

authors： Martone ME,Gupta A,Ellisman MH

更新日期：2004-05-01 00:00:00

abstract：:We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital...

journal_title：Nature neuroscience

authors： Armentano M,Chou SJ,Tomassy GS,Leingärtner A,O'Leary DD,Studer M

更新日期：2007-10-01 00:00:00

abstract：:The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad. ...

journal_title：Nature neuroscience

authors： Potter CJ,Luo L

更新日期：2008-09-01 00:00:00

abstract：:Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...

journal_title：Nature neuroscience

authors： Beuming T,Kniazeff J,Bergmann ML,Shi L,Gracia L,Raniszewska K,Newman AH,Javitch JA,Weinstein H,Gether U,Loland CJ

更新日期：2008-07-01 00:00:00