Octopamine fuels fighting flies.

abstract：:Using magnetoencephalography (MEG), we compared the processing of sinusoidal tones in the auditory cortex of 12 non-musicians, 12 professional musicians and 13 amateur musicians. We found neurophysiological and anatomical differences between groups. In professional musicians as compared to non-musicians, the activity ...

journal_title：Nature neuroscience

authors： Schneider P,Scherg M,Dosch HG,Specht HJ,Gutschalk A,Rupp A

更新日期：2002-07-01 00:00:00

abstract：:Agonists of GABA(B) receptors exert a bi-directional effect on the activity of dopamine (DA) neurons of the ventral tegmental area, which can be explained by the fact that coupling between GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK) channels is significantly weaker in DA neurons than in ...

journal_title：Nature neuroscience

authors： Labouèbe G,Lomazzi M,Cruz HG,Creton C,Luján R,Li M,Yanagawa Y,Obata K,Watanabe M,Wickman K,Boyer SB,Slesinger PA,Lüscher C

更新日期：2007-12-01 00:00:00

abstract：:We report a systematic relationship between sound-frequency tuning and sensitivity to interaural time delays for neurons in the midbrain nucleus of the inferior colliculus; neurons with relatively low best frequencies (BFs) showed response peaks at long delays, whereas neurons with relatively high BFs showed response ...

journal_title：Nature neuroscience

authors： McAlpine D,Jiang D,Palmer AR

更新日期：2001-04-01 00:00:00

abstract：:The production of hippocampal granule neurons continues throughout adulthood but dramatically decreases in old age. Here we show that reducing corticosteroid levels in aged rats restored the rate of cell proliferation, resulting in increased numbers of new granule neurons. This result indicates that the neuronal precu...

journal_title：Nature neuroscience

authors： Cameron HA,McKay RD

更新日期：1999-10-01 00:00:00

abstract：:A central question in the study of human behavior is the origin of willed action. EEG recordings of surface brain activity from human subjects performing a self-initiated movement show that the subjective experience of wanting to move follows, rather than precedes, the 'readiness potential'--an electrophysiological ma...

journal_title：Nature neuroscience

authors： Sirigu A,Daprati E,Ciancia S,Giraux P,Nighoghossian N,Posada A,Haggard P

更新日期：2004-01-01 00:00:00

abstract：:We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital...

journal_title：Nature neuroscience

authors： Armentano M,Chou SJ,Tomassy GS,Leingärtner A,O'Leary DD,Studer M

更新日期：2007-10-01 00:00:00

abstract：:Breathing is a bilaterally synchronous behavior that relies on a respiratory rhythm generator located in the brainstem. An essential component of this generator is the preBötzinger complex (preBötC), which paces inspirations. Little is known about the developmental origin of the interneuronal populations forming the p...

journal_title：Nature neuroscience

authors： Bouvier J,Thoby-Brisson M,Renier N,Dubreuil V,Ericson J,Champagnat J,Pierani A,Chédotal A,Fortin G

更新日期：2010-09-01 00:00:00

abstract：:The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental q...

journal_title：Nature neuroscience

authors： Xie J,Padoa-Schioppa C

更新日期：2016-06-01 00:00:00

abstract：:Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal ...

journal_title：Nature neuroscience

authors： Murray JD,Bernacchia A,Freedman DJ,Romo R,Wallis JD,Cai X,Padoa-Schioppa C,Pasternak T,Seo H,Lee D,Wang XJ

更新日期：2014-12-01 00:00:00

abstract：:Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...

journal_title：Nature neuroscience

authors： Galli R,Borello U,Gritti A,Minasi MG,Bjornson C,Coletta M,Mora M,De Angelis MG,Fiocco R,Cossu G,Vescovi AL

更新日期：2000-10-01 00:00:00

abstract：:The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying...

journal_title：Nature neuroscience

authors： Kiecker C,Lumsden A

更新日期：2004-11-01 00:00:00

abstract：:A localized transcriptome at the synapse facilitates synapse-, stimulus- and transcript-specific local protein synthesis in response to neuronal activity. While enzyme-mediated mRNA modifications are known to regulate cellular mRNA turnover, the role of these modifications in regulating synaptic RNA has not been studi...

journal_title：Nature neuroscience

authors： Merkurjev D,Hong WT,Iida K,Oomoto I,Goldie BJ,Yamaguti H,Ohara T,Kawaguchi SY,Hirano T,Martin KC,Pellegrini M,Wang DO

更新日期：2018-07-01 00:00:00

abstract：:Processing of rapidly successive acoustic stimuli can be markedly improved by sensory training. To investigate the cortical mechanisms underlying such temporal plasticity, we trained rats in a 'sound maze' in which navigation using only auditory cues led to a target location paired with food reward. In this task, the ...

journal_title：Nature neuroscience

authors： Bao S,Chang EF,Woods J,Merzenich MM

更新日期：2004-09-01 00:00:00

abstract：:The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses...

journal_title：Nature neuroscience

authors： Kay L,Humphreys L,Eickholt BJ,Burrone J

更新日期：2011-06-01 00:00:00

abstract：:The shift in ocular dominance induced by brief monocular deprivation is greatest during a postnatal critical period and is thought to decline irreversibly thereafter. However, here we demonstrate that complete visual deprivation through dark exposure restores rapid ocular dominance plasticity in adult rats. In additio...

journal_title：Nature neuroscience

authors： He HY,Ray B,Dennis K,Quinlan EM

更新日期：2007-09-01 00:00:00

abstract：:The meaning we derive from our experiences is not a simple static extraction of the elements but is largely based on the order in which those elements occur. Models propose that sequence encoding is supported by interactions between high- and low-frequency oscillations, such that elements within an experience are repr...

journal_title：Nature neuroscience

authors： Heusser AC,Poeppel D,Ezzyat Y,Davachi L

更新日期：2016-10-01 00:00:00

abstract：:Mammalian hearing owes its remarkable sensitivity and frequency selectivity to a local mechanical feedback process within the cochlea. Cochlear outer hair cells (OHCs) function as the key elements in the feedback loop in which the fast somatic motility of OHCs is thought to be the source of cochlear amplification. An ...

journal_title：Nature neuroscience

authors： Jia S,He DZ

更新日期：2005-08-01 00:00:00

abstract：:Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin)...

journal_title：Nature neuroscience

authors： Wilhelm BG,Groemer TW,Rizzoli SO

更新日期：2010-12-01 00:00:00

abstract：:Neural activity in visual area V4 is enhanced when attention is directed into neuronal receptive fields. However, the source of this enhancement is unclear, as most physiological studies have manipulated attention by changing the absolute reward associated with a particular location as well as its value relative to ot...

journal_title：Nature neuroscience

authors： Baruni JK,Lau B,Salzman CD

更新日期：2015-11-01 00:00:00

abstract：:Angelman syndrome (AS) is a severe neurological disorder characterized by mental retardation, motor dysfunction and epilepsy. We show that the molecular and cellular deficits of an AS mouse model can be rescued by introducing an additional mutation at the inhibitory phosphorylation site of alphaCaMKII. Moreover, these...

journal_title：Nature neuroscience

authors： van Woerden GM,Harris KD,Hojjati MR,Gustin RM,Qiu S,de Avila Freire R,Jiang YH,Elgersma Y,Weeber EJ

更新日期：2007-03-01 00:00:00

abstract：:The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by local...

journal_title：Nature neuroscience

authors： Makara JK,Losonczy A,Wen Q,Magee JC

更新日期：2009-12-01 00:00:00

abstract：:The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of...

journal_title：Nature neuroscience

authors： Li H,Penzo MA,Taniguchi H,Kopec CD,Huang ZJ,Li B

更新日期：2013-03-01 00:00:00

abstract：:Neuronal development, plasticity and survival require activity-dependent synapse-to-nucleus signaling. Most studies implicate an activity-dependent regulation of gene expression in this phenomenon. However, little is known about other nuclear functions that are regulated by synaptic activity. Here we show that a newly...

journal_title：Nature neuroscience

authors： Jordan BA,Fernholz BD,Khatri L,Ziff EB

更新日期：2007-04-01 00:00:00

abstract：:The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for vocal learning in juvenile songbirds. The shell subregion of LMAN (LMAN(shell)) gives rise to recurrent loops that may subserve specific learning-related functions....

journal_title：Nature neuroscience

authors： Bottjer SW,Altenau B

更新日期：2010-02-01 00:00:00

abstract：:The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which is characterized by changes in the tau protein and in the cleaved fragments of the amyloid precursor protein (APP). We used a high-resolution functional magnetic resonance imaging (fMRI) variant that can map metabolic defects i...

journal_title：Nature neuroscience

authors： Khan UA,Liu L,Provenzano FA,Berman DE,Profaci CP,Sloan R,Mayeux R,Duff KE,Small SA

更新日期：2014-02-01 00:00:00

abstract：:The weight of synaptic connections, which is controlled not only postsynaptically but also presynaptically, is a key determinant in neuronal network dynamics. The mechanisms controlling synaptic weight, especially on the presynaptic side, remain elusive. Using single-synapse imaging of the neurotransmitter glutamate c...

journal_title：Nature neuroscience

authors： Sakamoto H,Ariyoshi T,Kimpara N,Sugao K,Taiko I,Takikawa K,Asanuma D,Namiki S,Hirose K

更新日期：2018-01-01 00:00:00

abstract：:Microcircuits composed of principal neuron and interneuron dendrites have an important role in shaping the representation of sensory information in the olfactory bulb. Here we establish the physiological features governing synaptic signaling in dendrodendritic microcircuits of olfactory bulb glomeruli. We show that de...

journal_title：Nature neuroscience

authors： Murphy GJ,Darcy DP,Isaacson JS

更新日期：2005-03-01 00:00:00

abstract：:The origin of brain mechanisms that support human language-whether these originated de novo in humans or evolved from a neural substrate that existed in a common ancestor-remains a controversial issue. Although the answer is not provided by the fossil record, it is possible to make inferences by studying living specie...

journal_title：Nature neuroscience

authors： Gil-da-Costa R,Martin A,Lopes MA,Muñoz M,Fritz JB,Braun AR

更新日期：2006-08-01 00:00:00

abstract：:Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhi...

journal_title：Nature neuroscience

authors： Couey JJ,Witoelar A,Zhang SJ,Zheng K,Ye J,Dunn B,Czajkowski R,Moser MB,Moser EI,Roudi Y,Witter MP

更新日期：2013-03-01 00:00:00

abstract：:Major, rapid performance improvements in perceptual training are often dismissed as 'task' or 'procedural' learning because they are fast and generalize within a task. We assessed the contributions of perceptual and procedural learning to improvement in an auditory tone frequency learning task in humans and found that...

journal_title：Nature neuroscience

authors： Hawkey DJ,Amitay S,Moore DR

更新日期：2004-10-01 00:00:00