Abstract:
:Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attention-and for its flexible control and its interaction with processes such as working memory and decision making. While the contribution of recurrent cortical microcircuits to cognition has been extensively studied, the role of the thalamus is just beginning to be elucidated. Here we highlight recent studies across rodents and primates showing how thalamus contributes to attentional control. In addition to high-fidelity information relay to or between cortical regions, thalamic circuits shift and sustain functional interactions within and across cortical areas. This thalamic process enables rapid coordination of spatially segregated cortical computations, thereby constructing task-relevant functional networks. Because such function may be critical for cognitive flexibility, clarifying its mechanisms will likely expand our basic understanding of cognitive control and its perturbation in disease.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Halassa MM,Kastner Sdoi
10.1038/s41593-017-0020-1subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1669-1679issue
12eissn
1097-6256issn
1546-1726pii
10.1038/s41593-017-0020-1journal_volume
20pub_type
杂志文章,评审abstract::Many attempts to obtain reliable self-administration behavior by laboratory animals with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsuccessful. Because self-administration behavior has been demonstrated in laboratory animals for almost all other psychoactive drugs abused ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/80577
更新日期:2000-11-01 00:00:00
abstract::The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2540
更新日期:2010-06-01 00:00:00
abstract::Chronic morphine exposure upregulates adenylate cyclase signaling and reduces analgesic efficacy, a condition known as opioid tolerance. Nonopioid neurotransmitters can enhance morphine tolerance, but the mechanism for this is poorly understood. We show that morphine tolerance was delayed in mice lacking vasopressin 1...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0144-y
更新日期:2018-06-01 00:00:00
abstract::The CNS, which consists of the brain and spinal cord, is continuously monitored by resident microglia and blood-borne immune cells such as macrophages, dendritic cells and T cells to detect for damaging agents that would disrupt homeostasis and optimal functioning of these vital organs. Further, the CNS must balance b...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3161
更新日期:2012-07-26 00:00:00
abstract::What neural activity in motor cortex represents and how it controls ongoing movement remain unclear. Suggestions that cortex generates low-level muscle control are discredited by correlations with higher-level parameters of hand movement, but no coherent alternative exists. I argue that the view of low-level control i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/73964
更新日期:2000-04-01 00:00:00
abstract::Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex an...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4020
更新日期:2015-06-01 00:00:00
abstract::Increases in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have tested whether cocaine reinstatement in rats depends on interactions between accumbal dopamine and glutamate systems that are mediated by Ca(2+)...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2054
更新日期:2008-03-01 00:00:00
abstract::In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/1609
更新日期:1998-09-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-019-0570-5
更新日期:2020-02-01 00:00:00
abstract::In the version of this article initially published, what was originally described as 'conditioned place preference' in a two-chamber mouse experiment could be better described as 'conditioned place avoidance'. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0323-x
更新日期:2019-03-01 00:00:00
abstract::In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentiated from induced plurip...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0075-7
更新日期:2018-03-01 00:00:00
abstract::Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of this unusual 'interkinetic nuclear migration' are poorly understood. We investigated the basis for this behavior by live imaging of nuclei, centrosomes and microtubules in embryonic ra...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2665
更新日期:2010-12-01 00:00:00
abstract::The brain transforms physical sensory stimuli into meaningful perceptions. In animals making choices about sensory stimuli, neuronal activity in successive cortical stages reflects a progression from sensation to decision. Feedforward and feedback pathways connecting cortical areas are critical for this transformation...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4356
更新日期:2016-09-01 00:00:00
abstract::The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by local...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2428
更新日期:2009-12-01 00:00:00
abstract::Neurobiological theories of knowledge processing are biased toward the language-dominant (usually the left) hemisphere. Does the right hemisphere critically contribute to knowledge processing? J.A. is a left-hemisphere language-dominant individual who suffered a lesion confined to the right mid- and anterior fusiform ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1721
更新日期:2006-07-01 00:00:00
abstract::The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2826
更新日期:2011-06-01 00:00:00
abstract::Selective attention filters information to limit what is encoded and maintained in working memory. Although the prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Using functional magnetic resonance imag...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2773
更新日期:2011-05-01 00:00:00
abstract::The shift in ocular dominance induced by brief monocular deprivation is greatest during a postnatal critical period and is thought to decline irreversibly thereafter. However, here we demonstrate that complete visual deprivation through dark exposure restores rapid ocular dominance plasticity in adult rats. In additio...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1965
更新日期:2007-09-01 00:00:00
abstract::GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to s...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00752-x
更新日期:2021-01-01 00:00:00
abstract::We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2316
更新日期:2009-06-01 00:00:00
abstract::Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn835
更新日期:2002-05-01 00:00:00
abstract::Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3604
更新日期:2014-03-01 00:00:00
abstract::Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4517
更新日期:2017-04-01 00:00:00
abstract::A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1593
更新日期:2006-01-01 00:00:00
abstract::Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1672
更新日期:2006-04-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-020-00710-7
更新日期:2020-11-01 00:00:00
abstract::The morphological transition of growth cones to synaptic boutons characterizes synaptogenesis. Here we have isolated mutations in immaculate connections (imac; CG8566), a previously uncharacterized Drosophila gene encoding a member of the Kinesin-3 family. Whereas earlier studies in Drosophila implicated Kinesin-1 in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1936
更新日期:2007-08-01 00:00:00
abstract::In the postnatal subventricular zone (SVZ), local cues or signaling molecules released from neuroblasts limit the proliferation of glial fibrillary acidic protein (GFAP)-expressing progenitors thought to be stem cells. However, signals between SVZ cells have not been identified. We show that depolarization of neurobla...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1522
更新日期:2005-09-01 00:00:00
abstract::The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3322
更新日期:2013-03-01 00:00:00
abstract::Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By co...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1376
更新日期:2005-01-01 00:00:00