Abstract：
:Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development, which causes injury to vulnerable neurons and glia. Abnormal growth and maturation of susceptible cell types, particularly neurons and oligodendrocytes, in preterm babies with very low birth weight is associated with decreased cerebral and cerebellar volumes and increases in cerebral ventricular size. Here we reconcile these observations with recent studies using models of perinatal hypoxia that show perturbations in the maturation and function of interneurons, oligodendrocytes and astroglia. Together, these findings suggest that the global mechanism by which perinatal hypoxia alters development is through a delay in maturation of affected cell types, including astroglia, oligodendroglia and neurons.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Salmaso N,Jablonska B,Scafidi J,Vaccarino FM,Gallo Vdoi
10.1038/nn.3604subject
Has Abstractpub_date
2014-03-01 00:00:00pages
341-6issue
3eissn
1097-6256issn
1546-1726pii
nn.3604journal_volume
17pub_type
杂志文章,评审abstract：:The hindbrain transcription factors Phox2b and Egr2 (also known as Krox20) are linked to the development of the autonomic nervous system and rhombomere-related regulation of breathing, respectively. Mutations in these proteins can lead to abnormal breathing behavior as a result of an alteration in an unidentified neur...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2354
更新日期：2009-08-01 00:00:00
abstract：:The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental q...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4300
更新日期：2016-06-01 00:00:00
abstract：:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1023
更新日期：2003-04-01 00:00:00
abstract：:Dendritic spikes signal synaptic integration at remote apical dendritic sites in neocortical pyramidal neurons in vitro. Do dendritic spikes have a salient signaling role under in vivo conditions, where neocortical pyramidal neurons are bombarded with synaptic input? In the present study, levels of synaptic conductanc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1305
更新日期：2004-09-01 00:00:00
abstract：:It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LG...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4215
更新日期：2016-02-01 00:00:00
abstract：:T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0427-y
更新日期：2019-08-01 00:00:00
abstract：:Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into fear memory traces and are necessary for the ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3592
更新日期：2014-01-01 00:00:00
abstract：:Age-related decreases in neural function result in part from alterations in synapses. To identify molecular defects that lead to such changes, we focused on the outer retina, in which synapses are markedly altered in old rodents and humans. We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3772
更新日期：2014-09-01 00:00:00
abstract：:Motion and stereoscopic depth are fundamental parameters of the structural analysis of visual scenes. Because they are defined by a difference in object position, either over time or across the eyes, a common neural machinery may be used for encoding these attributes. To examine this idea, we analyzed responses of bin...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/87462
更新日期：2001-05-01 00:00:00
abstract：:Visual attention enhances the responses of visual neurons that encode the attended location. Several recent studies have shown that attention also decreases correlations between fluctuations in the responses of pairs of neurons (termed spike count correlation or r(SC)). These results are consistent with two hypotheses...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3835
更新日期：2014-11-01 00:00:00
abstract：:Although de novo missense mutations have been predicted to account for more cases of autism than gene-truncating mutations, most research has focused on the latter. We identified the properties of de novo missense mutations in patients with neurodevelopmental disorders (NDDs) and highlight 35 genes with excess missens...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4589
更新日期：2017-08-01 00:00:00
abstract：:Dot patterns sliding transparently across one another are normally perceived as independently moving surfaces. Recordings from direction-selective neurons in area MT of the macaque suggested that this perceptual segregation did not depend on the presence of two peaks in the population activity. Rather, the visual syst...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/72985
更新日期：2000-03-01 00:00:00
abstract：:In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAM...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2289
更新日期：2009-04-01 00:00:00
abstract：:Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1672
更新日期：2006-04-01 00:00:00
abstract：:Some neurons in auditory cortex respond to recent stimulus history by adapting their response functions to track stimulus statistics directly, as might be expected. In contrast, some neurons respond to loud sounds by adjusting their response functions away from high intensities and consequently remain sensitive to sof...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2201
更新日期：2008-11-01 00:00:00
abstract：:The 'cognitive map' hypothesis proposes that brain builds a unified representation of the spatial environment to support memory and guide future action. Forty years of electrophysiological research in rodents suggest that cognitive maps are neurally instantiated by place, grid, border and head direction cells in the h...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4656
更新日期：2017-10-26 00:00:00
abstract：:Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3862
更新日期：2014-12-01 00:00:00
abstract：:We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the ...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/82947
更新日期：2001-01-01 00:00:00
abstract：:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-017-0004-1
更新日期：2017-12-01 00:00:00
abstract：:Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4116
更新日期：2015-11-01 00:00:00
abstract：:A cognitive map has long been the dominant metaphor for hippocampal function, embracing the idea that place cells encode a geometric representation of space. However, evidence for predictive coding, reward sensitivity and policy dependence in place cells suggests that the representation is not purely spatial. We appro...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4650
更新日期：2017-11-01 00:00:00
abstract：:We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in learning and memory, and were repaired within 24 h. Increasing neu...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3356
更新日期：2013-05-01 00:00:00
abstract：:Tau protein can transfer between neurons transneuronally and trans-synaptically, which is thought to explain the progressive spread of tauopathy observed in the brain of patients with Alzheimer's disease. Here we show that physiological tau released from donor cells can transfer to recipient cells via the medium, sugg...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4328
更新日期：2016-08-01 00:00:00
abstract：:Visual information is delivered to the brain by >40 types of retinal ganglion cells (RGCs). Diversity in this representation arises within the inner plexiform layer (IPL), where dendrites of each RGC type are restricted to specific sublaminae, limiting the interneuronal types that can innervate them. How such dendriti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0127-z
更新日期：2018-05-01 00:00:00
abstract：:Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity accou...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/nn1616
更新日期：2006-01-01 00:00:00
abstract：:Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected that microglia would contribute to neurodegeneration. Howeve...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0083-7
更新日期：2018-03-01 00:00:00
abstract：:Behavior-contingent network oscillations bring about transient, functionally coherent neuronal assemblies in the cerebral cortex, including the hippocampus. Inhibitory input on and close to the soma is believed to phase intrinsic oscillations and output of pyramidal cells, but the function of GABA release to pyramidal...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1159
更新日期：2004-01-01 00:00:00
abstract：:Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3657
更新日期：2014-04-01 00:00:00
abstract：:Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2239
更新日期：2009-01-01 00:00:00
abstract：:Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypot...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3373
更新日期：2013-05-01 00:00:00
