Abstract:
:The CNS, which consists of the brain and spinal cord, is continuously monitored by resident microglia and blood-borne immune cells such as macrophages, dendritic cells and T cells to detect for damaging agents that would disrupt homeostasis and optimal functioning of these vital organs. Further, the CNS must balance between vigilantly detecting for potentially harmful factors and resolving any immunological responses that in themselves can create damage if left unabated. We discuss the physiological roles of the immune sentinels that patrol the CNS, the molecular markers that underlie their surveillance duties, and the consequences of interrupting their functions following injury and infection by viruses such as JC virus, human immunodeficiency virus, herpes simplex virus and West Nile virus.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Ousman SS,Kubes Pdoi
10.1038/nn.3161subject
Has Abstractpub_date
2012-07-26 00:00:00pages
1096-101issue
8eissn
1097-6256issn
1546-1726pii
nn.3161journal_volume
15pub_type
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