Abstract:
:Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate components by assigning adult mice to various conditions: water-maze learning (learner), swim-time-yoked control (swimmer), voluntary wheel running (runner), and enriched (enriched) and standard housing (control) groups. Neither maze training nor yoked swimming had any effect on bromodeoxyuridine (BrdU)-positive cell number. However, running doubled the number of surviving newborn cells, in amounts similar to enrichment conditions. Our findings demonstrate that voluntary exercise is sufficient for enhanced neurogenesis in the adult mouse dentate gyrus.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
van Praag H,Kempermann G,Gage FHdoi
10.1038/6368subject
Has Abstractpub_date
1999-03-01 00:00:00pages
266-70issue
3eissn
1097-6256issn
1546-1726journal_volume
2pub_type
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