Abstract：
:Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Lazarus M,Yoshida K,Coppari R,Bass CE,Mochizuki T,Lowell BB,Saper CBdoi
10.1038/nn1949subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1131-3issue
9eissn
1097-6256issn
1546-1726pii
nn1949journal_volume
10pub_type
杂志文章abstract：:An object viewed from different angles can be recognized and distinguished from similar distractors after the viewer has had experience watching it rotate. It has been assumed that as an observer watches the rotation, separate representations of individual views become associated with one another. However, we show her...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1600
更新日期：2005-12-01 00:00:00
abstract：:Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3397
更新日期：2013-06-01 00:00:00
abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0677-8
更新日期：2020-10-01 00:00:00
abstract：:Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2624
更新日期：2010-10-01 00:00:00
abstract：:Parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss of dopaminergic neurons innervating the striatum. As striatal dopamine levels fall, striatal acetylcholine release rises, exacerbating motor symptoms. This adaptation is commonly attributed to the loss of interneuronal regulation b...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1700
更新日期：2006-06-01 00:00:00
abstract：:The regulation of female reproductive behaviors may involve memories of male pheromone signatures, formed in part by neural circuitry involving the olfactory bulb and hippocampus. These neural structures are the principal sites of adult neurogenesis; however, previous studies point to their independent regulation by s...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1928
更新日期：2007-08-01 00:00:00
abstract：:Myelinating cells, oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system produce an enormous amount of plasma membrane during the myelination process, making them particularly susceptible to disruptions of the secretory pathway. Endoplasmic reticulum stress, initiated by the accumulation of un...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.2273
更新日期：2009-04-01 00:00:00
abstract：:In humans and many other animals, memory consolidation occurs through multiple temporal phases and usually involves more than one neuroanatomical brain system. Genetic dissection of Pavlovian olfactory learning in Drosophila melanogaster has revealed multiple memory phases, but the predominant view holds that all memo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2005
更新日期：2007-12-01 00:00:00
abstract：:Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3598
更新日期：2014-01-01 00:00:00
abstract：:In higher sensory cortices, there is a gradual transformation from sensation to perception and action. In the auditory system, this transformation is revealed by responses in the rostral ventral posterior auditory field (VPr), a tertiary area in the ferret auditory cortex, which shows long-term learning in trained com...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0317-8
更新日期：2019-03-01 00:00:00
abstract：:Central pattern generators (CPGs) are spinal neuronal networks required for locomotion. Glutamatergic neurons have been implicated as being important for intrinsic rhythm generation in the CPG and for the command signal for initiating locomotion, although this has not been demonstrated directly. We used a newly genera...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2482
更新日期：2010-02-01 00:00:00
abstract：:We report a systematic relationship between sound-frequency tuning and sensitivity to interaural time delays for neurons in the midbrain nucleus of the inferior colliculus; neurons with relatively low best frequencies (BFs) showed response peaks at long delays, whereas neurons with relatively high BFs showed response ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/86049
更新日期：2001-04-01 00:00:00
abstract：:The US government is re-examining how it funds science, but it remains to be seen whether the administration can overcome tradition and bureaucratic inertia and achieve a substantial renovation of the grants peer-review system. ...
journal_title：Nature neuroscience
pub_type： 社论
doi：10.1038/nn0208-119
更新日期：2008-02-01 00:00:00
abstract：:We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1137
更新日期：2003-11-01 00:00:00
abstract：:Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1150
更新日期：2003-12-01 00:00:00
abstract：:The usefulness of genetically encoded probes for optical monitoring of neuronal activity and brain circuits would be greatly advanced by the generation of multiple indicators with non-overlapping color spectra. Most existing indicators are derived from or spectrally convergent on GFP. We generated a bright, red, pH-se...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3126
更新日期：2012-05-27 00:00:00
abstract：:Bone morphogenetic proteins (BMPs), negative regulators of neural determination in the early embryo, were found to be potent inhibitors of neurogenesis in olfactory epithelium (OE) cultures. BMPs 2, 4 or 7 decreased the number of proliferating progenitor cells and blocked production of olfactory receptor neurons (ORNs...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/7251
更新日期：1999-04-01 00:00:00
abstract：:The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Ove...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4202
更新日期：2016-02-01 00:00:00
abstract：:Memory reconsolidation has been demonstrated in various tasks and species, suggesting it is a fundamental process. However, there are experimental parameters that can inhibit reconsolidation from occurring (boundary conditions). These conditions and their mechanisms remain poorly defined. Here, we characterize the abi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2350
更新日期：2009-07-01 00:00:00
abstract：:Adult expertise in face processing is mediated largely by neural networks in the right hemisphere. Here we evaluate the contribution of early visual input in establishing this neural substrate. We compared visually normal individuals to patients for whom visual input had been restricted mainly to one hemisphere during...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1121
更新日期：2003-10-01 00:00:00
abstract：:Sensorimotor integration is crucial to perception and motor control. How and where this process takes place in the brain is still largely unknown. Here we analyze the cerebellar contribution to sensorimotor integration in the whisker system of mice. We identify an area in the cerebellum where cortical sensory and moto...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3773
更新日期：2014-09-01 00:00:00
abstract：:To investigate synaptic events underlying sensory perception, we made whole-cell membrane potential recordings of barrel cortex neurons in awake mice while recording whisker-related behavior. During quiet periods, we recorded slow, large-amplitude membrane potential changes, which switched during whisking to small, fa...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1690
更新日期：2006-05-01 00:00:00
abstract：:EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1655
更新日期：2006-03-01 00:00:00
abstract：:We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1921
更新日期：2007-07-01 00:00:00
abstract：:We examined enhancement of synaptic transmission by neurotrophins at the presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased mitogen-activated protein (MAP) kinase-dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release. PD98059, used to in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/73888
更新日期：2000-04-01 00:00:00
abstract：:Behavior-contingent network oscillations bring about transient, functionally coherent neuronal assemblies in the cerebral cortex, including the hippocampus. Inhibitory input on and close to the soma is believed to phase intrinsic oscillations and output of pyramidal cells, but the function of GABA release to pyramidal...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1159
更新日期：2004-01-01 00:00:00
abstract：:The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2540
更新日期：2010-06-01 00:00:00
abstract：:From insects to mammals, olfactory receptor neurons (ORNs) expressing a common olfactory receptor target their axons to specific glomeruli with high precision. Here we show in Drosophila that the POU transcription factor Acj6 controls the axon targeting specificity of a subset of ORN classes, as defined by the olfacto...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1284
更新日期：2004-08-01 00:00:00
abstract：:A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0608-8
更新日期：2020-04-01 00:00:00
abstract：:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4378
更新日期：2016-09-27 00:00:00
