Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body.

abstract：:Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear. Activity-dependent transcription of genes for neurotrophins such as brain-derived neurotrophic factor (BDNF) has been shown to promote epileptogenesis; however, little is known a...

journal_title：Nature neuroscience

authors： Tan GH,Liu YY,Hu XL,Yin DM,Mei L,Xiong ZQ

更新日期：2011-12-11 00:00:00

abstract：:Replay of hippocampal place cell sequences has been proposed as a fundamental mechanism of learning and memory. However, the standard interpretation of replay has been challenged by reports that similar activity is observed before experience ('preplay'). By the preplay account, pre-existing temporal sequences are mapp...

journal_title：Nature neuroscience

authors： Silva D,Feng T,Foster DJ

更新日期：2015-12-01 00:00:00

abstract：:Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fe...

journal_title：Nature neuroscience

authors： Jovasevic V,Corcoran KA,Leaderbrand K,Yamawaki N,Guedea AL,Chen HJ,Shepherd GM,Radulovic J

更新日期：2015-09-01 00:00:00

abstract：:Although de novo missense mutations have been predicted to account for more cases of autism than gene-truncating mutations, most research has focused on the latter. We identified the properties of de novo missense mutations in patients with neurodevelopmental disorders (NDDs) and highlight 35 genes with excess missens...

journal_title：Nature neuroscience

authors： Geisheker MR,Heymann G,Wang T,Coe BP,Turner TN,Stessman HAF,Hoekzema K,Kvarnung M,Shaw M,Friend K,Liebelt J,Barnett C,Thompson EM,Haan E,Guo H,Anderlid BM,Nordgren A,Lindstrand A,Vandeweyer G,Alberti A,Avola E,V

更新日期：2017-08-01 00:00:00

abstract：:The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic regulation and nongenomic mechanisms. A key result of stress is structural remodeling of neural architecture, which may be a si...

journal_title：Nature neuroscience

authors： McEwen BS,Bowles NP,Gray JD,Hill MN,Hunter RG,Karatsoreos IN,Nasca C

更新日期：2015-10-01 00:00:00

abstract：:We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...

journal_title：Nature neuroscience

authors： Iftinca M,Hamid J,Chen L,Varela D,Tadayonnejad R,Altier C,Turner RW,Zamponi GW

更新日期：2007-07-01 00:00:00

abstract：:Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related ...

journal_title：Nature neuroscience

authors： Rao SM,Mayer AR,Harrington DL

更新日期：2001-03-01 00:00:00

abstract：:Temporal and quantitative relations between excitatory and inhibitory inputs in the cortex are central to its activity, yet they remain poorly understood. In particular, a controversy exists regarding the extent of correlation between cortical excitation and inhibition. Using simultaneous intracellular recordings in p...

journal_title：Nature neuroscience

authors： Okun M,Lampl I

更新日期：2008-05-01 00:00:00

abstract：:The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for vocal learning in juvenile songbirds. The shell subregion of LMAN (LMAN(shell)) gives rise to recurrent loops that may subserve specific learning-related functions....

journal_title：Nature neuroscience

authors： Bottjer SW,Altenau B

更新日期：2010-02-01 00:00:00

abstract：:Accurate optical reporting of electrical activity in genetically defined neuronal populations is a long-standing goal in neuroscience. We developed Accelerated Sensor of Action Potentials 1 (ASAP1), a voltage sensor design in which a circularly permuted green fluorescent protein is inserted in an extracellular loop of...

journal_title：Nature neuroscience

authors： St-Pierre F,Marshall JD,Yang Y,Gong Y,Schnitzer MJ,Lin MZ

更新日期：2014-06-01 00:00:00

abstract：:Behavior-contingent network oscillations bring about transient, functionally coherent neuronal assemblies in the cerebral cortex, including the hippocampus. Inhibitory input on and close to the soma is believed to phase intrinsic oscillations and output of pyramidal cells, but the function of GABA release to pyramidal...

journal_title：Nature neuroscience

authors： Klausberger T,Márton LF,Baude A,Roberts JD,Magill PJ,Somogyi P

更新日期：2004-01-01 00:00:00

abstract：:A moving grating elicits innate optomotor behavior in zebrafish larvae; they swim in the direction of perceived motion. We took advantage of this behavior, using computer-animated displays, to determine what attributes of motion are extracted by the fish visual system. As in humans, first-order (luminance-defined or F...

journal_title：Nature neuroscience

authors： Orger MB,Smear MC,Anstis SM,Baier H

更新日期：2000-11-01 00:00:00

abstract：:The morphological transition of growth cones to synaptic boutons characterizes synaptogenesis. Here we have isolated mutations in immaculate connections (imac; CG8566), a previously uncharacterized Drosophila gene encoding a member of the Kinesin-3 family. Whereas earlier studies in Drosophila implicated Kinesin-1 in ...

journal_title：Nature neuroscience

authors： Pack-Chung E,Kurshan PT,Dickman DK,Schwarz TL

更新日期：2007-08-01 00:00:00

abstract：:Attention powerfully influences auditory perception, but little is understood about the mechanisms whereby attention sharpens responses to unattended sounds. We used high-resolution surface mapping techniques (using functional magnetic resonance imaging, fMRI) to examine activity in human auditory cortex during an int...

journal_title：Nature neuroscience

authors： Petkov CI,Kang X,Alho K,Bertrand O,Yund EW,Woods DL

更新日期：2004-06-01 00:00:00

abstract：:Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin)...

journal_title：Nature neuroscience

authors： Wilhelm BG,Groemer TW,Rizzoli SO

更新日期：2010-12-01 00:00:00

abstract：:Human observers adapted to complex biological motions that distinguish males from females: viewing the gait of one gender biased judgments of subsequent gaits toward the opposite gender. This adaptation was not simply due to local features of the stimuli but instead relied upon the global motion of the figures. These ...

journal_title：Nature neuroscience

authors： Jordan H,Fallah M,Stoner GR

更新日期：2006-06-01 00:00:00

abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...

journal_title：Nature neuroscience

authors： Sangiamo DT,Warren MR,Neunuebel JP

更新日期：2020-03-01 00:00:00

abstract：:Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external...

journal_title：Nature neuroscience

authors： O'Hagan R,Chalfie M,Goodman MB

更新日期：2005-01-01 00:00:00

abstract：:Ample evidence suggests that primary visual cortex is involved in the perception of form, and there is increasing evidence that it may also be important in the perception of surfaces. Perceptual qualities of surfaces, such as brightness, are based on extensive integration of information throughout the visual field. In...

journal_title：Nature neuroscience

authors： MacEvoy SP,Kim W,Paradiso MA

更新日期：1998-11-01 00:00:00

abstract：:Perturbations of astrocytes trigger neurodegeneration in several diseases, but the glial cell-intrinsic mechanisms that induce neurodegeneration remain poorly understood. We found that a protein complex of α2-Na/K ATPase and α-adducin was enriched in astrocytes expressing mutant superoxide dismutase 1 (SOD1), which ca...

journal_title：Nature neuroscience

authors： Gallardo G,Barowski J,Ravits J,Siddique T,Lingrel JB,Robertson J,Steen H,Bonni A

更新日期：2014-12-01 00:00:00

abstract：:Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correl...

journal_title：Nature neuroscience

authors： Russo SJ,Murrough JW,Han MH,Charney DS,Nestler EJ

更新日期：2012-11-01 00:00:00

abstract：:Most neurons in macaque area MT are selective for the direction of stimulus motion. By comparing direction selectivity for gratings and plaids, we classified MT neurons as pattern direction selective (PDS) or component direction selective (CDS). We compared the time course of responses in CDS and PDS neurons in opiate...

journal_title：Nature neuroscience

authors： Smith MA,Majaj NJ,Movshon JA

更新日期：2005-02-01 00:00:00

abstract：:Ability to integrate diverse forms of information in current thought, or working memory, is essential for human reasoning and problem solving. We used functional imaging to identify brain regions preferentially involved in maintaining integrated versus unintegrated information in working memory. For equal amounts of v...

journal_title：Nature neuroscience

authors： Prabhakaran V,Narayanan K,Zhao Z,Gabrieli JD

更新日期：2000-01-01 00:00:00

abstract：:We introduce a deceptively simple behavioral task that robustly identifies two qualitatively different groups within the general population. When presented with an isochronous train of random syllables, some listeners are compelled to align their own concurrent syllable production with the perceived rate, whereas othe...

journal_title：Nature neuroscience

authors： Assaneo MF,Ripollés P,Orpella J,Lin WM,de Diego-Balaguer R,Poeppel D

更新日期：2019-04-01 00:00:00

abstract：:Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...

journal_title：Nature neuroscience

authors： Womelsdorf T,Valiante TA,Sahin NT,Miller KJ,Tiesinga P

更新日期：2014-08-01 00:00:00

abstract：:Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...

journal_title：Nature neuroscience

authors： Galli R,Borello U,Gritti A,Minasi MG,Bjornson C,Coletta M,Mora M,De Angelis MG,Fiocco R,Cossu G,Vescovi AL

更新日期：2000-10-01 00:00:00

abstract：:Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensembl...

journal_title：Nature neuroscience

authors： Cazakoff BN,Lau BY,Crump KL,Demmer HS,Shea SD

更新日期：2014-04-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Marschallinger J,Iram T,Zardeneta M,Lee SE,Lehallier B,Haney MS,Pluvinage JV,Mathur V,Hahn O,Morgens DW,Kim J,Tevini J,Felder TK,Wolinski H,Bertozzi CR,Bassik MC,Aigner L,Wyss-Coray T

更新日期：2020-02-01 00:00:00

abstract：:It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...

journal_title：Nature neuroscience

authors： Bosbach S,Cole J,Prinz W,Knoblich G

更新日期：2005-10-01 00:00:00

abstract：:A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...

journal_title：Nature neuroscience

authors： Makin JG,Moses DA,Chang EF

更新日期：2020-04-01 00:00:00