Broadly tuned and respiration-independent inhibition in the olfactory bulb of awake mice.

Abstract:

:Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensemble activity more sparse by facilitating lateral inhibition among MTs and/or enforce temporally precise activity locked to breathing. Yet the selectivity and temporal structure of wakeful GC activity are unknown. We recorded GCs in the MOB of anesthetized and awake mice and identified state-dependent features of odor coding and temporal patterning. Under anesthesia, GCs were sparsely active and strongly and synchronously coupled to respiration. Upon waking, GCs desynchronized, broadened their tuning and largely fired independently from respiration. Thus, during wakefulness, GCs exhibited stronger odor responses with less temporal structure. We propose that during wakefulness GCs may shape MT odor responses through broadened lateral interactions rather than respiratory synchronization.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Cazakoff BN,Lau BY,Crump KL,Demmer HS,Shea SD

doi

10.1038/nn.3669

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

569-76

issue

4

eissn

1097-6256

issn

1546-1726

pii

nn.3669

journal_volume

17

pub_type

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