Abstract：
:Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensemble activity more sparse by facilitating lateral inhibition among MTs and/or enforce temporally precise activity locked to breathing. Yet the selectivity and temporal structure of wakeful GC activity are unknown. We recorded GCs in the MOB of anesthetized and awake mice and identified state-dependent features of odor coding and temporal patterning. Under anesthesia, GCs were sparsely active and strongly and synchronously coupled to respiration. Upon waking, GCs desynchronized, broadened their tuning and largely fired independently from respiration. Thus, during wakefulness, GCs exhibited stronger odor responses with less temporal structure. We propose that during wakefulness GCs may shape MT odor responses through broadened lateral interactions rather than respiratory synchronization.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Cazakoff BN,Lau BY,Crump KL,Demmer HS,Shea SDdoi
10.1038/nn.3669subject
Has Abstractpub_date
2014-04-01 00:00:00pages
569-76issue
4eissn
1097-6256issn
1546-1726pii
nn.3669journal_volume
17pub_type
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