Abstract:
:Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correlative neuroendocrine markers that are associated with a resilient phenotype. In this review, we highlight a growing literature in rodents that is starting to complement the human work by identifying the active behavioral, neural, molecular and hormonal basis of resilience. The therapeutic implications of these findings are important and can pave the way for an innovative approach to drug development for a range of stress-related syndromes.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Russo SJ,Murrough JW,Han MH,Charney DS,Nestler EJdoi
10.1038/nn.3234subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1475-84issue
11eissn
1097-6256issn
1546-1726pii
nn.3234journal_volume
15pub_type
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