Inferring another's expectation from action: the role of peripheral sensation.

abstract：:The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We generated a comprehensive transcriptional profile of the separate stages of spontaneous remyelination that follow focal demyelination in the rat CNS and found that transcripts that encode the retinoid acid receptor RXR-γ were diffe...

journal_title：Nature neuroscience

authors： Huang JK,Jarjour AA,Nait Oumesmar B,Kerninon C,Williams A,Krezel W,Kagechika H,Bauer J,Zhao C,Baron-Van Evercooren A,Chambon P,Ffrench-Constant C,Franklin RJM

更新日期：2011-01-01 00:00:00

abstract：:Autophosphorylation of alpha calcium-calmodulin-dependent kinase II (alphaCaMKII) has been proposed to be the key event in memory storage. We tested this hypothesis with autophosphorylation-deficient mutant mice in hippocampus- and amygdala-dependent learning and memory tasks and found that the autophosphorylation of ...

journal_title：Nature neuroscience

authors： Irvine EE,Vernon J,Giese KP

更新日期：2005-04-01 00:00:00

abstract：:Neural activity exhibits complex dynamics related to various brain functions, internal states and behaviors. Understanding how neural dynamics explain specific measured behaviors requires dissociating behaviorally relevant and irrelevant dynamics, which is not achieved with current neural dynamic models as they are le...

journal_title：Nature neuroscience

authors： Sani OG,Abbaspourazad H,Wong YT,Pesaran B,Shanechi MM

更新日期：2021-01-01 00:00:00

abstract：:Independent evidence associates β-amyloid pathology with both non-rapid eye movement (NREM) sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated ov...

journal_title：Nature neuroscience

authors： Mander BA,Marks SM,Vogel JW,Rao V,Lu B,Saletin JM,Ancoli-Israel S,Jagust WJ,Walker MP

更新日期：2015-07-01 00:00:00

abstract：:Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...

journal_title：Nature neuroscience

authors： Tsunoda K,Yamane Y,Nishizaki M,Tanifuji M

更新日期：2001-08-01 00:00:00

abstract：:It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to m...

journal_title：Nature neuroscience

authors： Kupchik YM,Brown RM,Heinsbroek JA,Lobo MK,Schwartz DJ,Kalivas PW

更新日期：2015-09-01 00:00:00

abstract：:Visual information is delivered to the brain by >40 types of retinal ganglion cells (RGCs). Diversity in this representation arises within the inner plexiform layer (IPL), where dendrites of each RGC type are restricted to specific sublaminae, limiting the interneuronal types that can innervate them. How such dendriti...

journal_title：Nature neuroscience

authors： Liu J,Reggiani JDS,Laboulaye MA,Pandey S,Chen B,Rubenstein JLR,Krishnaswamy A,Sanes JR

更新日期：2018-05-01 00:00:00

abstract：:Laboratory models, including animal tissues and live animals, have proven useful for discovery of molecular targets of alcohol action as well as for characterization of genetic and environmental factors that influence alcohol's neural actions. Here we consider strengths and weaknesses of laboratory models used in alco...

journal_title：Nature neuroscience

authors： Lovinger DM,Crabbe JC

更新日期：2005-11-01 00:00:00

abstract：:Neuronal activity-induced gene expression modulates the function and plasticity of the nervous system. It is unknown whether and to what extent neuronal activity may trigger changes in chromatin accessibility, a major mode of epigenetic regulation of gene expression. Here we compared chromatin accessibility landscapes...

journal_title：Nature neuroscience

authors： Su Y,Shin J,Zhong C,Wang S,Roychowdhury P,Lim J,Kim D,Ming GL,Song H

更新日期：2017-03-01 00:00:00

abstract：:Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-s...

journal_title：Nature neuroscience

authors： Mendoza-Halliday D,Torres S,Martinez-Trujillo JC

更新日期：2014-09-01 00:00:00

abstract：:Over the past two centuries, prevalent models of energy and glucose homeostasis have emerged from careful anatomical descriptions in tandem with an understanding of cellular physiology. More recent technological advances have culminated in the identification of peripheral and central factors that influence neural circ...

journal_title：Nature neuroscience

authors： Williams KW,Elmquist JK

更新日期：2012-10-01 00:00:00

abstract：:An afterimage looks larger when one fixates on a distant than on a closer surface. We show that the retinotopic activity in the primary visual cortex (V1) associated with viewing an afterimage is modulated by perceived size, even when the size of the retinal image remains constant. This suggests that V1 has an importa...

journal_title：Nature neuroscience

authors： Sperandio I,Chouinard PA,Goodale MA

更新日期：2012-03-11 00:00:00

abstract：:Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external...

journal_title：Nature neuroscience

authors： O'Hagan R,Chalfie M,Goodman MB

更新日期：2005-01-01 00:00:00

abstract：:Many neural signaling receptors are regulated by endocytosis, but little is known about receptor insertion into the plasma membrane. Time-lapse imaging of the beta2 adrenergic receptor expressed in cultured rat hippocampal neurons, using pH-sensitive green fluorescent protein tagging and total internal reflection fluo...

journal_title：Nature neuroscience

authors： Yudowski GA,Puthenveedu MA,von Zastrow M

更新日期：2006-05-01 00:00:00

abstract：:The endocytosis of AMPA receptors (AMPARs) underlies several forms of synaptic plasticity, including NMDA receptor (NMDAR)-dependent long-term depression (LTD), but the molecular mechanisms responsible for this trafficking remain unknown. We found that PSD-95, a major postsynaptic density protein, is important for NMD...

journal_title：Nature neuroscience

authors： Bhattacharyya S,Biou V,Xu W,Schlüter O,Malenka RC

更新日期：2009-02-01 00:00:00

abstract：:Learning and memory are associated with the formation and modification of neuronal assemblies: populations of neurons that encode what has been learned and mediate memory retrieval upon recall. Functional studies of neuronal assemblies have progressed dramatically thanks to recent technological advances. Here we discu...

journal_title：Nature neuroscience

authors： Holtmaat A,Caroni P

更新日期：2016-12-01 00:00:00

abstract：:Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers...

journal_title：Nature neuroscience

authors： Bibel M,Richter J,Schrenk K,Tucker KL,Staiger V,Korte M,Goetz M,Barde YA

更新日期：2004-09-01 00:00:00

abstract：:In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortica...

journal_title：Nature neuroscience

authors： Reyes A,Lujan R,Rozov A,Burnashev N,Somogyi P,Sakmann B

更新日期：1998-08-01 00:00:00

abstract：:Neuroscience seeks to understand how neural circuits lead to behavior. However, the gap between circuits and behavior is too wide. An intermediate level is one of neural computations, which occur in individual neurons and populations of neurons. Some computations seem to be canonical: repeated and combined in differen...

journal_title：Nature neuroscience

authors： Carandini M

更新日期：2012-03-27 00:00:00

abstract：:The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses of the cholinergic system. After release into the synaptic cleft, ACh is rapidly degraded by acetylcholinesterase (AChE). We have identified a mutation in the ache gene of the zebrafish, which abolishes ACh hydrolysis in ...

journal_title：Nature neuroscience

authors： Behra M,Cousin X,Bertrand C,Vonesch JL,Biellmann D,Chatonnet A,Strähle U

更新日期：2002-02-01 00:00:00

abstract：:All the higher mental and cognitive functions unique to humans depend on the neocortex ('new' cortex, referring to its relatively recent appearance in evolution), which is divided into discrete areas that subserve distinct functions, such as language, movement and sensation. With a few notable exceptions, all neocorti...

journal_title：Nature neuroscience

authors： Monuki ES,Walsh CA

更新日期：2001-11-01 00:00:00

abstract：:Sensory systems create neural representations of environmental stimuli and these representations can be associated with other stimuli through learning. Are spike patterns the neural representations that get directly associated with reinforcement during conditioning? In the moth Manduca sexta, we found that odor presen...

journal_title：Nature neuroscience

authors： Ito I,Ong RC,Raman B,Stopfer M

更新日期：2008-10-01 00:00:00

abstract：:EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants ...

journal_title：Nature neuroscience

authors： Carvalho RF,Beutler M,Marler KJ,Knöll B,Becker-Barroso E,Heintzmann R,Ng T,Drescher U

更新日期：2006-03-01 00:00:00

abstract：:The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...

journal_title：Nature neuroscience

authors： Schulz A,Baader SL,Niwa-Kawakita M,Jung MJ,Bauer R,Garcia C,Zoch A,Schacke S,Hagel C,Mautner VF,Hanemann CO,Dun XP,Parkinson DB,Weis J,Schröder JM,Gutmann DH,Giovannini M,Morrison H

更新日期：2013-04-01 00:00:00

abstract：:Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fe...

journal_title：Nature neuroscience

authors： Jovasevic V,Corcoran KA,Leaderbrand K,Yamawaki N,Guedea AL,Chen HJ,Shepherd GM,Radulovic J

更新日期：2015-09-01 00:00:00

abstract：:Economic choice entails assigning values to the available options and is impaired by lesions to the orbitofrontal cortex (OFC). Recent results show that some neurons in the OFC encode the values that monkeys (Macaca mulatta) assign to different goods when they choose between them. A broad and fundamental question is h...

journal_title：Nature neuroscience

authors： Padoa-Schioppa C,Assad JA

更新日期：2008-01-01 00:00:00

abstract：:A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that bind the regulatory subunits of protein kinase A (PKA). AKAP binding to PKA regulates the phosphorylation of various proteins, some of which have been implicated in synaptic plasticity and memory consolidation. Here we show that the r...

journal_title：Nature neuroscience

authors： Moita MA,Lamprecht R,Nader K,LeDoux JE

更新日期：2002-09-01 00:00:00

abstract：:Central pattern generators (CPGs) are spinal neuronal networks required for locomotion. Glutamatergic neurons have been implicated as being important for intrinsic rhythm generation in the CPG and for the command signal for initiating locomotion, although this has not been demonstrated directly. We used a newly genera...

journal_title：Nature neuroscience

authors： Hägglund M,Borgius L,Dougherty KJ,Kiehn O

更新日期：2010-02-01 00:00:00

abstract：:The endocytosis of AMPA receptors is thought to be important in the expression of long-term depression (LTD) triggered by NMDA receptor activation. Although signaling pathways necessary for LTD induction have been identified, those responsible for the regulated internalization of AMPA receptors are unknown. Here we sh...

journal_title：Nature neuroscience

authors： Beattie EC,Carroll RC,Yu X,Morishita W,Yasuda H,von Zastrow M,Malenka RC

更新日期：2000-12-01 00:00:00

abstract：:Brain tumor initiating cells (BTICs) co-opt the neuronal high affinity glucose transporter, GLUT3, to withstand metabolic stress. We investigated another mechanism critical to brain metabolism, mitochondrial morphology, in BTICs. BTIC mitochondria were fragmented relative to non-BTIC tumor cell mitochondria, suggestin...

journal_title：Nature neuroscience

authors： Xie Q,Wu Q,Horbinski CM,Flavahan WA,Yang K,Zhou W,Dombrowski SM,Huang Z,Fang X,Shi Y,Ferguson AN,Kashatus DF,Bao S,Rich JN

更新日期：2015-04-01 00:00:00