Abstract：
:The endocytosis of AMPA receptors is thought to be important in the expression of long-term depression (LTD) triggered by NMDA receptor activation. Although signaling pathways necessary for LTD induction have been identified, those responsible for the regulated internalization of AMPA receptors are unknown. Here we show that activation of NMDA receptors alone can trigger AMPA receptor endocytosis through calcium influx and activation of the calcium-dependent protein phosphatase calcineurin. A distinct signaling mechanism mediates the AMPA receptor endocytosis stimulated by insulin. These results demonstrate that although multiple signaling pathways can induce AMPA receptor internalization, NMDA receptor activation enhances AMPA receptor endocytosis via a signaling mechanism required for the induction of LTD.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Beattie EC,Carroll RC,Yu X,Morishita W,Yasuda H,von Zastrow M,Malenka RCdoi
10.1038/81823subject
Has Abstractpub_date
2000-12-01 00:00:00pages
1291-300issue
12eissn
1097-6256issn
1546-1726journal_volume
3pub_type
杂志文章abstract：:Synaptic stimulation activates signal transduction pathways, producing persistently active protein kinases. PKMzeta is a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks the N-terminal pseudosubstrate regulatory domain. Using a Pavlovian olfactory learning task in Drosop...
journal_title：Nature neuroscience
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abstract：:In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article. ...
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journal_title：Nature neuroscience
pub_type： 杂志文章
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2005-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-02-01 00:00:00
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doi：10.1038/nn.2534
更新日期：2010-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn1376
更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-08-01 00:00:00
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更新日期：2007-12-01 00:00:00
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pub_type： 已发布勘误
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更新日期：2017-11-01 00:00:00
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更新日期：2000-04-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2013-05-01 00:00:00
