Abstract:
:We report two functional magnetic resonance imaging experiments showing enhanced responses in human middle superior temporal sulcus for angry relative to neutral prosody. This emotional enhancement was voice specific, unrelated to isolated acoustic amplitude or frequency cues in angry prosody, and distinct from any concomitant task-related attentional modulation. Attention and emotion seem to have separate effects on stimulus processing, reflecting a fundamental principle of human brain organization shared by voice and face perception.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Grandjean D,Sander D,Pourtois G,Schwartz S,Seghier ML,Scherer KR,Vuilleumier Pdoi
10.1038/nn1392subject
Has Abstractpub_date
2005-02-01 00:00:00pages
145-6issue
2eissn
1097-6256issn
1546-1726pii
nn1392journal_volume
8pub_type
杂志文章abstract::Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipol...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2816
更新日期:2011-06-01 00:00:00
abstract::The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by local...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2428
更新日期:2009-12-01 00:00:00
abstract::The mechanism by which adult neural stem cells (NSCs) are established during development is unclear. In this study, analysis of cell cycle progression by examining retention of a histone 2B (H2B)-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows betwe...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3989
更新日期:2015-05-01 00:00:00
abstract::Despite the numerous examples of anticipatory cognitive processes at micro and macro levels in many animal species, the idea that anticipation of specific words plays an integral role in real-time language processing has been contentious. Here we exploited a phonological regularity of English indefinite articles ('an'...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1504
更新日期:2005-08-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of con...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1718
更新日期:2006-07-01 00:00:00
abstract::It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1535
更新日期:2005-10-01 00:00:00
abstract::Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1672
更新日期:2006-04-01 00:00:00
abstract::Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopam...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1438
更新日期:2005-05-01 00:00:00
abstract::The painful sensations produced by a laceration, freeze, burn, muscle strain or internal injury are readily distinguishable because each is characterized by a particular sensory quality such as sharp, aching, burning or prickling. We propose that there are specific neural correlates of each pain quality, and here we u...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn955
更新日期:2002-11-01 00:00:00
abstract::Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Only recombinant NMDA receptors composed of NR1/NR2A exhibit a fast component of desensitization similar to neuronal NMDA receptors. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn0901-894
更新日期:2001-09-01 00:00:00
abstract::Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca(2+) concentration ([Ca(2+)]). Rapidly decaying [Ca(2+)] elevations were generated using Ca(2+) uncaging techniques, and [Ca(2+)] was measured with a low-affinity Ca(2+) indicator in a giant presynaptic terminal, the calyx o...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1417
更新日期:2005-04-01 00:00:00
abstract::An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indire...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/89522
更新日期:2001-07-01 00:00:00
abstract::The control of cell fate in neural progenitor cells is critical for nervous system development. Nevertheless, the processes involved are only partially known. We found that the expression of the tumor suppressor Pml was restricted to neural progenitor cells (NPCs) in the developing neocortex of the mouse. Notably, in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2251
更新日期:2009-02-01 00:00:00
abstract::Neuroscience seeks to understand how neural circuits lead to behavior. However, the gap between circuits and behavior is too wide. An intermediate level is one of neural computations, which occur in individual neurons and populations of neurons. Some computations seem to be canonical: repeated and combined in differen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3043
更新日期:2012-03-27 00:00:00
abstract::Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neuro...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/78800
更新日期:2000-09-01 00:00:00
abstract::Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood. We found that neuronal deletion of Hdac3 in mice el...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4347
更新日期:2016-11-01 00:00:00
abstract::Temporal and quantitative relations between excitatory and inhibitory inputs in the cortex are central to its activity, yet they remain poorly understood. In particular, a controversy exists regarding the extent of correlation between cortical excitation and inhibition. Using simultaneous intracellular recordings in p...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2105
更新日期:2008-05-01 00:00:00
abstract::Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypot...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3373
更新日期:2013-05-01 00:00:00
abstract::Ca(v)2.1 channels, which mediate P/Q-type Ca2+ currents, undergo Ca2+/calmodulin (CaM)-dependent inactivation and facilitation that can significantly alter synaptic efficacy. Here we report that the neuronal Ca2+-binding protein 1 (CaBP1) modulates Ca(v)2.1 channels in a manner that is markedly different from modulati...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn805
更新日期:2002-03-01 00:00:00
abstract::The precise role of synchronous neuronal firing in signal encoding remains unclear. To examine what kinds of signals can be carried by synchrony, I reproduced a multilayer feedforward network of neurons in an in vitro slice preparation of rat cortex using an iterative procedure. When constant and time-varying frequenc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1056
更新日期:2003-06-01 00:00:00
abstract::Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4489
更新日期:2017-03-01 00:00:00
abstract::Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1805
更新日期:2006-12-01 00:00:00
abstract::The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4475
更新日期:2017-02-01 00:00:00
abstract::Ongoing sensory input is critical for shaping internal representations of the external world. Conversely, a lack of sensory input can profoundly perturb the formation of these representations. The olfactory system is particularly vulnerable to sensory deprivation, owing to the widespread prevalence of allergic, viral ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3186
更新日期:2012-09-01 00:00:00
abstract::At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically ac...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1450
更新日期:2005-05-01 00:00:00
abstract::Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3604
更新日期:2014-03-01 00:00:00
abstract::Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhi...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3310
更新日期:2013-03-01 00:00:00
abstract::Social behaviors recruit multiple cognitive operations that require interactions between cortical and subcortical brain regions. Interareal synchrony may facilitate such interactions between cortical and subcortical neural populations. However, it remains unknown how neurons from different nodes in the social brain ne...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-0593-y
更新日期:2020-04-01 00:00:00
abstract::TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cro...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2778
更新日期:2011-04-01 00:00:00
abstract::Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped patte...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1505
更新日期:2005-08-01 00:00:00