Abstract：
:The precise role of synchronous neuronal firing in signal encoding remains unclear. To examine what kinds of signals can be carried by synchrony, I reproduced a multilayer feedforward network of neurons in an in vitro slice preparation of rat cortex using an iterative procedure. When constant and time-varying frequency signals were delivered to the network, the firing of neurons in successive layers became progressively more synchronous. Notably, synchrony in the in vitro network developed even with uncorrelated input, persisted under a wide range of physiological conditions and was crucial for the stable propagation of rate signals. The firing rate was represented by a classical rate code in the initial layers, but switched to a synchrony-based code in the deeper layers.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Reyes ADdoi
10.1038/nn1056subject
Has Abstractpub_date
2003-06-01 00:00:00pages
593-9issue
6eissn
1097-6256issn
1546-1726pii
nn1056journal_volume
6pub_type
杂志文章abstract：:Neurons in the rat primary auditory cortex (A1) generally cannot respond to tone sequences faster than 12 pulses per second (pps). To test whether experience can modify this maximum following rate in adult rats, trains of brief tones with random carrier frequency but fixed repetition rate were paired with electrical s...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/3729
更新日期：1998-12-01 00:00:00
abstract：:Neuroligins are postsynaptic cell adhesion molecules that are important for synaptic function through their trans-synaptic interaction with neurexins (NRXNs). The localization and synaptic effects of neuroligin-1 (NL-1, also called NLGN1) are specific to excitatory synapses with the capacity to enhance excitatory syna...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3601
更新日期：2014-01-01 00:00:00
abstract：:Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-00761-w
更新日期：2020-12-21 00:00:00
abstract：:Dopamine is vital for coordinated motion and for association learning linked to behavioral reinforcement. Here we show that the precise overlap of striatal dopaminergic and cholinergic fibers underlies potent control of dopamine release by ongoing nicotinic receptor activity. In mouse striatal slices, nicotinic antago...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn769
更新日期：2001-12-01 00:00:00
abstract：:The US government is re-examining how it funds science, but it remains to be seen whether the administration can overcome tradition and bureaucratic inertia and achieve a substantial renovation of the grants peer-review system. ...
journal_title：Nature neuroscience
pub_type： 社论
doi：10.1038/nn0208-119
更新日期：2008-02-01 00:00:00
abstract：:Microglia, the brain's intrinsic immune cells, rapidly sense brain injury and help clear cellular debris. Haynes et al. now show that P2Y12 receptors are critical for activating microglia and directing them to the site of injury. ...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章
doi：10.1038/nn1206-1463
更新日期：2006-12-01 00:00:00
abstract：:Mammalian sterile 20-like kinase-3b (Mst3b, encoded by Stk24), regulates axon outgrowth in embryonic cortical neurons in culture, but its role in vivo and in neural repair is unknown. Here we show that Mst3b mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal r...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2414
更新日期：2009-11-01 00:00:00
abstract：:In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0111-7
更新日期：2018-06-01 00:00:00
abstract：:Many cells in retinotopic brain areas increase their activity when saccades (rapid eye movements) are about to bring stimuli into their receptive fields. Although previous work has attempted to look at the functional correlates of such predictive remapping, no study has explicitly tested for better attentional perform...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2711
更新日期：2011-02-01 00:00:00
abstract：:The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4350
更新日期：2016-09-01 00:00:00
abstract：:Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1980
更新日期：2007-10-01 00:00:00
abstract：:Human observers adapted to complex biological motions that distinguish males from females: viewing the gait of one gender biased judgments of subsequent gaits toward the opposite gender. This adaptation was not simply due to local features of the stimuli but instead relied upon the global motion of the figures. These ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1710
更新日期：2006-06-01 00:00:00
abstract：:Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Only recombinant NMDA receptors composed of NR1/NR2A exhibit a fast component of desensitization similar to neuronal NMDA receptors. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn0901-894
更新日期：2001-09-01 00:00:00
abstract：:Temporal and quantitative relations between excitatory and inhibitory inputs in the cortex are central to its activity, yet they remain poorly understood. In particular, a controversy exists regarding the extent of correlation between cortical excitation and inhibition. Using simultaneous intracellular recordings in p...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2105
更新日期：2008-05-01 00:00:00
abstract：:During development and aging and in amblyopia, visual acuity is far below the limitations set by the retina. Expression of brain-derived neurotrophic factor (BDNF) in the visual cortex is reduced in these situations. We asked whether neurotrophic tyrosine kinase receptor, type 2 (TrkB) regulates cortical visual acuity...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2534
更新日期：2010-05-01 00:00:00
abstract：:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1023
更新日期：2003-04-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4186
更新日期：2016-01-01 00:00:00
abstract：:Individual differences in motor learning ability are widely acknowledged, yet little is known about the factors that underlie them. Here we explore whether movement-to-movement variability in motor output, a ubiquitous if often unwanted characteristic of motor performance, predicts motor learning ability. Surprisingly...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3616
更新日期：2014-02-01 00:00:00
abstract：:Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked end...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1126
更新日期：2003-10-01 00:00:00
abstract：:In the version of this article initially published, what was originally described as 'conditioned place preference' in a two-chamber mouse experiment could be better described as 'conditioned place avoidance'. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0323-x
更新日期：2019-03-01 00:00:00
abstract：:Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known which aspect of reward processing is responsible for this. We separated decision value and prediction error signals and found that neural prediction error signals in the striatum peaked in adolescence, whereas neural d...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2558
更新日期：2010-06-01 00:00:00
abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0119-z
更新日期：2018-05-01 00:00:00
abstract：:Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in est...
journal_title：Nature neuroscience
pub_type： 评论,新闻
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更新日期：2010-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3215
更新日期：2012-10-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-020-0595-9
更新日期：2020-02-01 00:00:00
abstract：:The origin of brain mechanisms that support human language-whether these originated de novo in humans or evolved from a neural substrate that existed in a common ancestor-remains a controversial issue. Although the answer is not provided by the fossil record, it is possible to make inferences by studying living specie...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1741
更新日期：2006-08-01 00:00:00
abstract：:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4378
更新日期：2016-09-27 00:00:00
abstract：:Autophosphorylation of alpha calcium-calmodulin-dependent kinase II (alphaCaMKII) has been proposed to be the key event in memory storage. We tested this hypothesis with autophosphorylation-deficient mutant mice in hippocampus- and amygdala-dependent learning and memory tasks and found that the autophosphorylation of ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1431
更新日期：2005-04-01 00:00:00
abstract：:Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3636
更新日期：2014-03-01 00:00:00
abstract：:Differentiation of CNS glia is regulated by Notch signaling through neuron-glia interaction. Here, we identified Delta/Notch-like EGF-related receptor (DNER), a neuron-specific transmembrane protein, as a previously unknown ligand of Notch during cellular morphogenesis of Bergmann glia in the mouse cerebellum. DNER bi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1492
更新日期：2005-07-01 00:00:00
