Abstract：
:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylation of cyclic AMP-responsive element binding protein (CREB), and MAP kinase inhibitors blocked these inductions. An increase in CREB phosphorylation and L-LTP induced by one-train tetanus were observed in the multiparous mouse hippocampus without oxytocin application. Furthermore, intracerebroventricular injection of oxytocin in virgin mice improved long-term spatial learning in vivo, whereas an injection of oxytocin antagonist in multiparous mice significantly inhibited the improved spatial memory, L-LTP and CREB phosphorylation. These findings indicate that oxytocin is critically involved in improving hippocampus-dependent learning and memory during motherhood in mice.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Tomizawa K,Iga N,Lu YF,Moriwaki A,Matsushita M,Li ST,Miyamoto O,Itano T,Matsui Hdoi
10.1038/nn1023subject
Has Abstractpub_date
2003-04-01 00:00:00pages
384-90issue
4eissn
1097-6256issn
1546-1726pii
nn1023journal_volume
6pub_type
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