Abstract：
:Modeling of human neuropsychiatric disorders in animals is extremely challenging given the subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests, and the early state of the relevant neurobiology and genetics. Nonetheless, progress in understanding pathophysiology and in treatment development would benefit greatly from improved animal models. Here we review the current state of animal models of mental illness, with a focus on schizophrenia, depression and bipolar disorder. We argue for areas of focus that might increase the likelihood of creating more useful models, at least for some disorders, and for explicit guidelines when animal models are reported.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Nestler EJ,Hyman SEdoi
10.1038/nn.2647subject
Has Abstractpub_date
2010-10-01 00:00:00pages
1161-9issue
10eissn
1097-6256issn
1546-1726pii
nn.2647journal_volume
13pub_type
杂志文章,评审abstract：:EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, given that EphBs signal through multiple mechanisms, it has been challenging to define which signaling fun...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3249
更新日期：2012-12-01 00:00:00
abstract：:Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood. We found that neuronal deletion of Hdac3 in mice el...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4347
更新日期：2016-11-01 00:00:00
abstract：:Activity in the primary auditory cortex (A1) is essential for normal sound localization behavior, but previous studies of the spatial sensitivity of neurons in A1 have found broad spatial tuning. We tested the hypothesis that spatial tuning sharpens when an animal engages in an auditory task. Cats performed a task tha...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2713
更新日期：2011-01-01 00:00:00
abstract：:Ongoing sensory input is critical for shaping internal representations of the external world. Conversely, a lack of sensory input can profoundly perturb the formation of these representations. The olfactory system is particularly vulnerable to sensory deprivation, owing to the widespread prevalence of allergic, viral ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3186
更新日期：2012-09-01 00:00:00
abstract：:The 'cognitive map' hypothesis proposes that brain builds a unified representation of the spatial environment to support memory and guide future action. Forty years of electrophysiological research in rodents suggest that cognitive maps are neurally instantiated by place, grid, border and head direction cells in the h...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4656
更新日期：2017-10-26 00:00:00
abstract：:Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2076
更新日期：2008-04-01 00:00:00
abstract：:Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/13149
更新日期：1999-10-01 00:00:00
abstract：:Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3051
更新日期：2012-02-26 00:00:00
abstract：:The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Ove...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4202
更新日期：2016-02-01 00:00:00
abstract：:Rapid progress has been made in understanding the synaptic changes required for memory encoding. Several companies are now attempting to use information about the induction and consolidation phases of this process to build memory-enhancing drugs. These efforts have produced novel compounds that improve retention score...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn935
更新日期：2002-11-01 00:00:00
abstract：:Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-017-0020-1
更新日期：2017-12-01 00:00:00
abstract：:Visual information is delivered to the brain by >40 types of retinal ganglion cells (RGCs). Diversity in this representation arises within the inner plexiform layer (IPL), where dendrites of each RGC type are restricted to specific sublaminae, limiting the interneuronal types that can innervate them. How such dendriti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0127-z
更新日期：2018-05-01 00:00:00
abstract：:Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2762
更新日期：2011-04-01 00:00:00
abstract：:Bright objects capture our attention by virtue of 'popping out' from their surroundings. This correlates with strong responses in cortical areas thought to be important in attentional allocation. Previous studies have suggested that with the right mindset or training, humans can ignore popout stimuli. We studied the a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1734
更新日期：2006-08-01 00:00:00
abstract：:How different are the neuronal circuits for a given behavior across individual animals? To address this question, we measured multiple cellular and synaptic parameters in individual preparations to see how they correlated with circuit function, using neurons and synapses in the pyloric circuit of the stomatogastric ga...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2404
更新日期：2009-11-01 00:00:00
abstract：:Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation has been implicated in a wide range of diseases. Here we demonstrate that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like recepto...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3449
更新日期：2013-08-01 00:00:00
abstract：:Temporal regulation of embryonic neurogenesis is controlled by hypostable transcription factors. The mechanism of the process is unclear. Here we show that the RNase III Drosha and DGCR8 (also known as Pasha), key components of the microRNA (miRNA) microprocessor, have important functions in mouse neurogenesis. Loss o...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3139
更新日期：2012-06-17 00:00:00
abstract：:To define the role of the Raf serine/threonine kinases in nervous system development, we conditionally targeted B-Raf and C-Raf, two of the three known mammalian Raf homologs, using a mouse line expressing Cre recombinase driven by a nestin promoter. Targeting of B-Raf, but not C-Raf, markedly attenuated baseline phos...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1898
更新日期：2007-05-01 00:00:00
abstract：:By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and 1,077 trios, we identified a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10(-9)). We found only two heterozygous LoF variants in 45,376 exomes fro...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4267
更新日期：2016-04-01 00:00:00
abstract：:Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic inte...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3710
更新日期：2014-06-01 00:00:00
abstract：:Individuals' risk attitudes are known to guide choices about uncertain options. However, in the presence of others' decisions, these choices can be swayed and manifest as riskier or safer behavior than one would express alone. To test the mechanisms underlying effective social 'nudges' in human decision-making, we use...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4022
更新日期：2015-06-01 00:00:00
abstract：:Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0370-y
更新日期：2019-05-01 00:00:00
abstract：:Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that both the identity of activated neurons and the timing of their activity convey information about odors. However, whether and how downstream neurons decipher these temporal patterns remains unknown. We addressed this question...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3407
更新日期：2013-07-01 00:00:00
abstract：:Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca2+ imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0254-6
更新日期：2018-11-01 00:00:00
abstract：:We used ultrasound image-guided injections of high-titer retroviral vectors to obtain widespread introduction of genes into the mouse nervous system in utero as early as embryonic day 8.5 (E8.5). The vectors used included internal promoters that substantially improved proviral gene expression in the ventricular zone o...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/12186
更新日期：1999-09-01 00:00:00
abstract：:It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LG...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4215
更新日期：2016-02-01 00:00:00
abstract：:During development and aging and in amblyopia, visual acuity is far below the limitations set by the retina. Expression of brain-derived neurotrophic factor (BDNF) in the visual cortex is reduced in these situations. We asked whether neurotrophic tyrosine kinase receptor, type 2 (TrkB) regulates cortical visual acuity...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2534
更新日期：2010-05-01 00:00:00
abstract：:Here we used magnetoencephalography (MEG) to investigate stages of processing in face perception in humans. We found a face-selective MEG response occurring only 100 ms after stimulus onset (the 'M100'), 70 ms earlier than previously reported. Further, the amplitude of this M100 response was correlated with successful...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn909
更新日期：2002-09-01 00:00:00
abstract：:Although much learning occurs through direct experience of errors, humans and other animals can learn from the errors of other individuals. The medial frontal cortex (MFC) processes self-generated errors, but the neuronal architecture and mechanisms underlying the monitoring of others' errors are poorly understood. Ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3180
更新日期：2012-09-01 00:00:00
abstract：:Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent l...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2750
更新日期：2011-03-01 00:00:00
