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PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.

Abstract：

:Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form of PIKE, designated PIKE-L, which, unlike the nuclear PIKE-S, localizes to both the cytoplasm and the nucleus. We demonstrate physiologic binding of PIKE-L to Homer, an adaptor protein known to link metabotropic glutamate receptors to multiple intracellular targets including the inositol 1,4,5-trisphosphate receptor (IP3R). We show that activation of group I metabotropic glutamate receptors (mGluRIs) enhances formation of an mGluRI-Homer-PIKE-L complex, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Our findings indicate that this complex mediates the well-known ability of agonists of mGluRI to prevent neuronal apoptosis.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Rong R,Ahn JY,Huang H,Nagata E,Kalman D,Kapp JA,Tu J,Worley PF,Snyder SH,Ye K

doi

10.1038/nn1134

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

1153-61

issue

11

eissn

1097-6256

issn

1546-1726

pii

nn1134

journal_volume

6

pub_type

杂志文章

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