K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.

abstract：:Ongoing sensory input is critical for shaping internal representations of the external world. Conversely, a lack of sensory input can profoundly perturb the formation of these representations. The olfactory system is particularly vulnerable to sensory deprivation, owing to the widespread prevalence of allergic, viral ...

journal_title：Nature neuroscience

authors： Wu KN,Tan BK,Howard JD,Conley DB,Gottfried JA

更新日期：2012-09-01 00:00:00

abstract：:During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is ...

journal_title：Nature neuroscience

authors： Nery S,Fishell G,Corbin JG

更新日期：2002-12-01 00:00:00

abstract：:Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...

journal_title：Nature neuroscience

authors： Halassa MM,Kastner S

更新日期：2017-12-01 00:00:00

abstract：:Cell type-specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 and archaerhodopsi...

journal_title：Nature neuroscience

authors： Madisen L,Mao T,Koch H,Zhuo JM,Berenyi A,Fujisawa S,Hsu YW,Garcia AJ 3rd,Gu X,Zanella S,Kidney J,Gu H,Mao Y,Hooks BM,Boyden ES,Buzsáki G,Ramirez JM,Jones AR,Svoboda K,Han X,Turner EE,Zeng H

更新日期：2012-03-25 00:00:00

abstract：:Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extincti...

journal_title：Nature neuroscience

authors： Hauner KK,Howard JD,Zelano C,Gottfried JA

更新日期：2013-11-01 00:00:00

abstract：:Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this vulnerability is not understood. To explore possible physiological determinants, we studied LC neurons using electrophysiological and optical approa...

journal_title：Nature neuroscience

authors： Sanchez-Padilla J,Guzman JN,Ilijic E,Kondapalli J,Galtieri DJ,Yang B,Schieber S,Oertel W,Wokosin D,Schumacker PT,Surmeier DJ

更新日期：2014-06-01 00:00:00

abstract：:Recording from neural networks at the resolution of action potentials is critical for understanding how information is processed in the brain. Here, we address this challenge by developing an organic material-based, ultraconformable, biocompatible and scalable neural interface array (the 'NeuroGrid') that can record b...

journal_title：Nature neuroscience

authors： Khodagholy D,Gelinas JN,Thesen T,Doyle W,Devinsky O,Malliaras GG,Buzsáki G

更新日期：2015-02-01 00:00:00

abstract：:Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plastici...

journal_title：Nature neuroscience

authors： Lee HK,Min SS,Gallagher M,Kirkwood A

更新日期：2005-12-01 00:00:00

abstract：:The majority of neurons in primary visual cortex are tuned for stimulus orientation, but the factors that account for the range of orientation selectivities exhibited by cortical neurons remain unclear. To address this issue, we used in vivo two-photon calcium imaging to characterize the orientation tuning and spatial...

journal_title：Nature neuroscience

authors： Wilson DE,Whitney DE,Scholl B,Fitzpatrick D

更新日期：2016-08-01 00:00:00

abstract：:Individual behavioral performance during learning is known to be affected by modulatory factors, such as stress and motivation, and by genetic predispositions that influence sensitivity to these factors. Despite numerous studies, no integrative framework is available that could predict how a given animal would perform...

journal_title：Nature neuroscience

authors： Luksys G,Gerstner W,Sandi C

更新日期：2009-09-01 00:00:00

abstract：:Several ion channels are thought to be directly modulated by nitric oxide (NO), but the molecular basis of this regulation is unclear. Here we show that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO. Site-directed mutagenesis identified a critical cys...

journal_title：Nature neuroscience

authors： Choi YB,Tenneti L,Le DA,Ortiz J,Bai G,Chen HS,Lipton SA

更新日期：2000-01-01 00:00:00

abstract：:Active dendritic integration is thought to enrich the computational power of central neurons. However, a direct role of active dendritic processing in the execution of defined neuronal computations in intact neural networks has not been established. Here we used multi-site electrophysiological recording techniques to ...

journal_title：Nature neuroscience

authors： Sivyer B,Williams SR

更新日期：2013-12-01 00:00:00

abstract：:The precise period when experience shapes neural circuits in the mouse visual system is unknown. We used Arc induction to monitor the functional pattern of ipsilateral eye representation in cortex during normal development and after visual deprivation. After monocular deprivation during the critical period, Arc induct...

journal_title：Nature neuroscience

authors： Tagawa Y,Kanold PO,Majdan M,Shatz CJ

更新日期：2005-03-01 00:00:00

abstract：:Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...

journal_title：Nature neuroscience

authors： Huang H,Kong D,Byun KH,Ye C,Koda S,Lee DH,Oh BC,Lee SW,Lee B,Zabolotny JM,Kim MS,Bjørbæk C,Lowell BB,Kim YB

更新日期：2012-10-01 00:00:00

abstract：:Multiple protein kinase C (PKC) isozymes are present in neurons, where they regulate a variety of cellular functions. Due to the lack of specific PKC isozyme inhibitors, it remains unknown how PKC acts on its selective target(s) and achieves its specific actions. Here we show that a PKC binding protein, enigma homolog...

journal_title：Nature neuroscience

authors： Maeno-Hikichi Y,Chang S,Matsumura K,Lai M,Lin H,Nakagawa N,Kuroda S,Zhang JF

更新日期：2003-05-01 00:00:00

abstract：:Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, ...

journal_title：Nature neuroscience

authors： Miller KL,Alfaro-Almagro F,Bangerter NK,Thomas DL,Yacoub E,Xu J,Bartsch AJ,Jbabdi S,Sotiropoulos SN,Andersson JL,Griffanti L,Douaud G,Okell TW,Weale P,Dragonu I,Garratt S,Hudson S,Collins R,Jenkinson M,Matthews PM,

更新日期：2016-11-01 00:00:00

abstract：:Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 ca...

journal_title：Nature neuroscience

authors： Demontis D,Rajagopal VM,Thorgeirsson TE,Als TD,Grove J,Leppälä K,Gudbjartsson DF,Pallesen J,Hjorthøj C,Reginsson GW,Tyrfingsson T,Runarsdottir V,Qvist P,Christensen JH,Bybjerg-Grauholm J,Bækvad-Hansen M,Huckins LM,Stahl

更新日期：2019-07-01 00:00:00

abstract：:Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to ...

journal_title：Nature neuroscience

authors： Kress GJ,Yamawaki N,Wokosin DL,Wickersham IR,Shepherd GM,Surmeier DJ

更新日期：2013-06-01 00:00:00

abstract：:Ample evidence suggests that primary visual cortex is involved in the perception of form, and there is increasing evidence that it may also be important in the perception of surfaces. Perceptual qualities of surfaces, such as brightness, are based on extensive integration of information throughout the visual field. In...

journal_title：Nature neuroscience

authors： MacEvoy SP,Kim W,Paradiso MA

更新日期：1998-11-01 00:00:00

abstract：:Neuroimaging studies show that the efficacy of long-term memory encoding of a stimulus is indexed by transient neural activity elicited by that stimulus. Here, we show that successful memory encoding is also indexed by neural activity that is tonically maintained throughout a study task. Using functional magnetic reso...

journal_title：Nature neuroscience

authors： Otten LJ,Henson RN,Rugg MD

更新日期：2002-12-01 00:00:00

abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...

journal_title：Nature neuroscience

authors： Lischinsky JE,Lin D

更新日期：2020-11-01 00:00:00

abstract：:Learning and memory are associated with the formation and modification of neuronal assemblies: populations of neurons that encode what has been learned and mediate memory retrieval upon recall. Functional studies of neuronal assemblies have progressed dramatically thanks to recent technological advances. Here we discu...

journal_title：Nature neuroscience

authors： Holtmaat A,Caroni P

更新日期：2016-12-01 00:00:00

abstract：:Angelman syndrome (AS) is a severe neurological disorder characterized by mental retardation, motor dysfunction and epilepsy. We show that the molecular and cellular deficits of an AS mouse model can be rescued by introducing an additional mutation at the inhibitory phosphorylation site of alphaCaMKII. Moreover, these...

journal_title：Nature neuroscience

authors： van Woerden GM,Harris KD,Hojjati MR,Gustin RM,Qiu S,de Avila Freire R,Jiang YH,Elgersma Y,Weeber EJ

更新日期：2007-03-01 00:00:00

abstract：:The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...

journal_title：Nature neuroscience

authors： Ran C,Hoon MA,Chen X

更新日期：2016-09-01 00:00:00

abstract：:The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual ...

journal_title：Nature neuroscience

authors： Muzio L,Di Benedetto B,Stoykova A,Boncinelli E,Gruss P,Mallamaci A

更新日期：2002-08-01 00:00:00

abstract：:Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...

journal_title：Nature neuroscience

authors： Poulter S,Lee SA,Dachtler J,Wills TJ,Lever C

更新日期：2020-12-21 00:00:00

abstract：:The auditory system encodes sound by decomposing the amplitude signal arriving at the ear into multiple frequency bands whose center frequencies and bandwidths are approximately exponential functions of the distance from the stapes. This organization is thought to result from the adaptation of cochlear mechanisms to t...

journal_title：Nature neuroscience

authors： Lewicki MS

更新日期：2002-04-01 00:00:00

abstract：:Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that both the identity of activated neurons and the timing of their activity convey information about odors. However, whether and how downstream neurons decipher these temporal patterns remains unknown. We addressed this question...

journal_title：Nature neuroscience

authors： Haddad R,Lanjuin A,Madisen L,Zeng H,Murthy VN,Uchida N

更新日期：2013-07-01 00:00:00

abstract：:It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LG...

journal_title：Nature neuroscience

authors： Kondo S,Ohki K

更新日期：2016-02-01 00:00:00

abstract：:The most critical attribute of human language is its unbounded combinatorial nature: smaller elements can be combined into larger structures on the basis of a grammatical system, resulting in a hierarchy of linguistic units, such as words, phrases and sentences. Mentally parsing and representing such structures, howev...

journal_title：Nature neuroscience

authors： Ding N,Melloni L,Zhang H,Tian X,Poeppel D

更新日期：2016-01-01 00:00:00