Efficient coding of natural sounds.

abstract：:Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...

journal_title：Nature neuroscience

authors： Sreenivasan S,Fiete I

更新日期：2011-09-11 00:00:00

abstract：:Economic choice entails assigning values to the available options and is impaired by lesions to the orbitofrontal cortex (OFC). Recent results show that some neurons in the OFC encode the values that monkeys (Macaca mulatta) assign to different goods when they choose between them. A broad and fundamental question is h...

journal_title：Nature neuroscience

authors： Padoa-Schioppa C,Assad JA

更新日期：2008-01-01 00:00:00

abstract：:In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAM...

journal_title：Nature neuroscience

authors： Cygnar KD,Zhao H

更新日期：2009-04-01 00:00:00

abstract：:Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...

journal_title：Nature neuroscience

authors： Tsunoda K,Yamane Y,Nishizaki M,Tanifuji M

更新日期：2001-08-01 00:00:00

abstract：:The neural mechanisms that mediate the transition from a drug-naive state to a state of drug dependence and addiction are not yet known. Here we show that a discrete population of GABA(A) receptors in the mammalian ventral tegmental area (VTA) serves as a potential addiction switching mechanism by gating reward transm...

journal_title：Nature neuroscience

authors： Laviolette SR,Gallegos RA,Henriksen SJ,van der Kooy D

更新日期：2004-02-01 00:00:00

abstract：:Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear. Activity-dependent transcription of genes for neurotrophins such as brain-derived neurotrophic factor (BDNF) has been shown to promote epileptogenesis; however, little is known a...

journal_title：Nature neuroscience

authors： Tan GH,Liu YY,Hu XL,Yin DM,Mei L,Xiong ZQ

更新日期：2011-12-11 00:00:00

abstract：:Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this vulnerability is not understood. To explore possible physiological determinants, we studied LC neurons using electrophysiological and optical approa...

journal_title：Nature neuroscience

authors： Sanchez-Padilla J,Guzman JN,Ilijic E,Kondapalli J,Galtieri DJ,Yang B,Schieber S,Oertel W,Wokosin D,Schumacker PT,Surmeier DJ

更新日期：2014-06-01 00:00:00

abstract：:The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...

journal_title：Nature neuroscience

authors： Prinz M,Priller J

更新日期：2017-02-01 00:00:00

abstract：:Synaptic stimulation activates signal transduction pathways, producing persistently active protein kinases. PKMzeta is a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks the N-terminal pseudosubstrate regulatory domain. Using a Pavlovian olfactory learning task in Drosop...

journal_title：Nature neuroscience

authors： Drier EA,Tello MK,Cowan M,Wu P,Blace N,Sacktor TC,Yin JC

更新日期：2002-04-01 00:00:00

abstract：:Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neuro...

journal_title：Nature neuroscience

authors： Magee JC,Cook EP

更新日期：2000-09-01 00:00:00

abstract：:Increases in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have tested whether cocaine reinstatement in rats depends on interactions between accumbal dopamine and glutamate systems that are mediated by Ca(2+)...

journal_title：Nature neuroscience

authors： Anderson SM,Famous KR,Sadri-Vakili G,Kumaresan V,Schmidt HD,Bass CE,Terwilliger EF,Cha JH,Pierce RC

更新日期：2008-03-01 00:00:00

abstract：:The most critical attribute of human language is its unbounded combinatorial nature: smaller elements can be combined into larger structures on the basis of a grammatical system, resulting in a hierarchy of linguistic units, such as words, phrases and sentences. Mentally parsing and representing such structures, howev...

journal_title：Nature neuroscience

authors： Ding N,Melloni L,Zhang H,Tian X,Poeppel D

更新日期：2016-01-01 00:00:00

abstract：:Parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss of dopaminergic neurons innervating the striatum. As striatal dopamine levels fall, striatal acetylcholine release rises, exacerbating motor symptoms. This adaptation is commonly attributed to the loss of interneuronal regulation b...

journal_title：Nature neuroscience

authors： Ding J,Guzman JN,Tkatch T,Chen S,Goldberg JA,Ebert PJ,Levitt P,Wilson CJ,Hamm HE,Surmeier DJ

更新日期：2006-06-01 00:00:00

abstract：:Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped patte...

journal_title：Nature neuroscience

authors： Huberman AD,Murray KD,Warland DK,Feldheim DA,Chapman B

更新日期：2005-08-01 00:00:00

abstract：:Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...

journal_title：Nature neuroscience

authors： Womelsdorf T,Valiante TA,Sahin NT,Miller KJ,Tiesinga P

更新日期：2014-08-01 00:00:00

abstract：:Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein...

journal_title：Nature neuroscience

authors： Tian D,Stoppel LJ,Heynen AJ,Lindemann L,Jaeschke G,Mills AA,Bear MF

更新日期：2015-02-01 00:00:00

abstract：:Transposable elements, known colloquially as 'jumping genes', constitute approximately 45% of the human genome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencing heterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearanc...

journal_title：Nature neuroscience

authors： Sun W,Samimi H,Gamez M,Zare H,Frost B

更新日期：2018-08-01 00:00:00

abstract：:Candidate Drosophila olfactory receptors (ORs) provide molecular tools to investigate how the organization of the Drosophila olfactory system determines the coding of olfactory stimuli. Neurons in the third antennal segment and maxillary palp appear to express different ORs. Individual olfactory neurons send axonal pr...

journal_title：Nature neuroscience

authors： Gao Q,Yuan B,Chess A

更新日期：2000-08-01 00:00:00

abstract：:Humans and other primates sample the visual environment using saccadic eye movements that shift a high-resolution fovea toward regions of interest to create a clear perception of a scene across fixations. Many mammals, however, like mice, lack a fovea, which raises the question of why they make saccades. Here we descr...

journal_title：Nature neuroscience

authors： Samonds JM,Geisler WS,Priebe NJ

更新日期：2018-11-01 00:00:00

abstract：:The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad. ...

journal_title：Nature neuroscience

authors： Potter CJ,Luo L

更新日期：2008-09-01 00:00:00

abstract：:Very little is known about how stimuli that are typically not rich in sugars, such as beer, trigger attractive gustatory responses in Drosophila. We identified a member of the gustatory receptor family, Gr64e, as a receptor that is required for feeding preference for beer and other sources that have fermenting yeast. ...

journal_title：Nature neuroscience

authors： Wisotsky Z,Medina A,Freeman E,Dahanukar A

更新日期：2011-11-06 00:00:00

abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...

journal_title：Nature neuroscience

authors： Takahashi N,Ebner C,Sigl-Glöckner J,Moberg S,Nierwetberg S,Larkum ME

更新日期：2020-10-01 00:00:00

abstract：:Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of ...

journal_title：Nature neuroscience

authors： Tellez LA,Han W,Zhang X,Ferreira TL,Perez IO,Shammah-Lagnado SJ,van den Pol AN,de Araujo IE

更新日期：2016-03-01 00:00:00

abstract：:Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood. We found that neuronal deletion of Hdac3 in mice el...

journal_title：Nature neuroscience

authors： Nott A,Cheng J,Gao F,Lin YT,Gjoneska E,Ko T,Minhas P,Zamudio AV,Meng J,Zhang F,Jin P,Tsai LH

更新日期：2016-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease whose causes are still poorly understood. To identify additional genetic risk factors, we assessed the role of de novo mutations in ALS by sequencing the exomes of 47 ALS patients and both of their unaffected parents (n = 141 exomes). We fo...

journal_title：Nature neuroscience

authors： Chesi A,Staahl BT,Jovičić A,Couthouis J,Fasolino M,Raphael AR,Yamazaki T,Elias L,Polak M,Kelly C,Williams KL,Fifita JA,Maragakis NJ,Nicholson GA,King OD,Reed R,Crabtree GR,Blair IP,Glass JD,Gitler AD

更新日期：2013-07-01 00:00:00

abstract：:Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypot...

journal_title：Nature neuroscience

authors： Inoue W,Baimoukhametova DV,Füzesi T,Wamsteeker Cusulin JI,Koblinger K,Whelan PJ,Pittman QJ,Bains JS

更新日期：2013-05-01 00:00:00

abstract：:Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that...

journal_title：Nature neuroscience

authors： Lamprecht R,Farb CR,Rodrigues SM,LeDoux JE

更新日期：2006-04-01 00:00:00

abstract：:The launch of the US BRAIN and European Human Brain Projects coincides with growing international efforts toward transparency and increased access to publicly funded research in the neurosciences. The need for data-sharing standards and neuroinformatics infrastructure is more pressing than ever. However, 'big science'...

journal_title：Nature neuroscience

authors： Ferguson AR,Nielson JL,Cragin MH,Bandrowski AE,Martone ME

更新日期：2014-11-01 00:00:00

abstract：:The specification of area identities in the cerebral cortex is a complex process, primed by intrinsic cortical cues and refined after the arrival of afferent fibers from the thalamus. Little is known about the genetic control of the early steps of this process, but the distinctive expression pattern of the homeogene E...

journal_title：Nature neuroscience

authors： Mallamaci A,Muzio L,Chan CH,Parnavelas J,Boncinelli E

更新日期：2000-07-01 00:00:00

abstract：:Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We rep...

journal_title：Nature neuroscience

authors： Yasuda H,Barth AL,Stellwagen D,Malenka RC

更新日期：2003-01-01 00:00:00