Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex.

abstract：:Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Only recombinant NMDA receptors composed of NR1/NR2A exhibit a fast component of desensitization similar to neuronal NMDA receptors. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc...

journal_title：Nature neuroscience

authors： Zheng F,Erreger K,Low CM,Banke T,Lee CJ,Conn PJ,Traynelis SF

更新日期：2001-09-01 00:00:00

abstract：:Basal dendrites receive the majority of synapses that contact neocortical pyramidal neurons, yet our knowledge of synaptic processing in these dendrites has been hampered by their inaccessibility for electrical recordings. A new approach to patch-clamp recordings enabled us to characterize the integrative properties o...

journal_title：Nature neuroscience

authors： Nevian T,Larkum ME,Polsky A,Schiller J

更新日期：2007-02-01 00:00:00

abstract：:Temporal and quantitative relations between excitatory and inhibitory inputs in the cortex are central to its activity, yet they remain poorly understood. In particular, a controversy exists regarding the extent of correlation between cortical excitation and inhibition. Using simultaneous intracellular recordings in p...

journal_title：Nature neuroscience

authors： Okun M,Lampl I

更新日期：2008-05-01 00:00:00

abstract：:Growing evidence suggests that the recognition of different emotional states involves at least partly separable neural circuits. Here we assessed the discrimination of both anger and happiness in healthy subjects receiving transcranial magnetic stimulation (TMS) over the medial-frontal cortex or over a control site (m...

journal_title：Nature neuroscience

authors： Harmer CJ,Thilo KV,Rothwell JC,Goodwin GM

更新日期：2001-01-01 00:00:00

abstract：:Microcircuits composed of principal neuron and interneuron dendrites have an important role in shaping the representation of sensory information in the olfactory bulb. Here we establish the physiological features governing synaptic signaling in dendrodendritic microcircuits of olfactory bulb glomeruli. We show that de...

journal_title：Nature neuroscience

authors： Murphy GJ,Darcy DP,Isaacson JS

更新日期：2005-03-01 00:00:00

abstract：:Human behavior is mostly composed of habitual actions that require little conscious control. Such actions may become invalid if the environment changes, at which point individuals need to switch behavior by overcoming habitual actions that are otherwise triggered automatically. It is unknown how the brain controls thi...

journal_title：Nature neuroscience

authors： Isoda M,Hikosaka O

更新日期：2007-02-01 00:00:00

abstract：:Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plastici...

journal_title：Nature neuroscience

authors： Lee HK,Min SS,Gallagher M,Kirkwood A

更新日期：2005-12-01 00:00:00

abstract：:To determine the number of open Ca(2+) channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca(2+) imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca(2+) channels triggered tr...

journal_title：Nature neuroscience

authors： Bucurenciu I,Bischofberger J,Jonas P

更新日期：2010-01-01 00:00:00

abstract：:The brain transforms physical sensory stimuli into meaningful perceptions. In animals making choices about sensory stimuli, neuronal activity in successive cortical stages reflects a progression from sensation to decision. Feedforward and feedback pathways connecting cortical areas are critical for this transformation...

journal_title：Nature neuroscience

authors： Kwon SE,Yang H,Minamisawa G,O'Connor DH

更新日期：2016-09-01 00:00:00

abstract：:High and low spatial frequency information in visual images is processed by distinct neural channels. Using event-related functional magnetic resonance imaging (fMRI) in humans, we show dissociable roles of such visual channels for processing faces and emotional fearful expressions. Neural responses in fusiform cortex...

journal_title：Nature neuroscience

authors： Vuilleumier P,Armony JL,Driver J,Dolan RJ

更新日期：2003-06-01 00:00:00

abstract：:Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known neurofilament-dependent slowing of axonal transport, combined with the prominent misaccumulation of neurofilaments in ALS, su...

journal_title：Nature neuroscience

authors： Williamson TL,Cleveland DW

更新日期：1999-01-01 00:00:00

abstract：:A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and brain damage. Despite the involvement of distinct proteins in different NDs, the process of protein misfolding and aggregation is remarka...

journal_title：Nature neuroscience

authors： Soto C,Pritzkow S

更新日期：2018-10-01 00:00:00

abstract：:The precise role of synchronous neuronal firing in signal encoding remains unclear. To examine what kinds of signals can be carried by synchrony, I reproduced a multilayer feedforward network of neurons in an in vitro slice preparation of rat cortex using an iterative procedure. When constant and time-varying frequenc...

journal_title：Nature neuroscience

authors： Reyes AD

更新日期：2003-06-01 00:00:00

abstract：:Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent l...

journal_title：Nature neuroscience

authors： Larsen RS,Corlew RJ,Henson MA,Roberts AC,Mishina M,Watanabe M,Lipton SA,Nakanishi N,Pérez-Otaño I,Weinberg RJ,Philpot BD

更新日期：2011-03-01 00:00:00

abstract：:The retina of warm-blooded vertebrates is believed to be incapable of neural regeneration. Here we provide evidence that the retina of postnatal chickens has the potential to generate new neurons. In response to acute damage, numerous Müller glia re-entered the cell cycle, and shortly thereafter, expressed CASH-1, Pax...

journal_title：Nature neuroscience

authors： Fischer AJ,Reh TA

更新日期：2001-03-01 00:00:00

abstract：:Multiple protein kinase C (PKC) isozymes are present in neurons, where they regulate a variety of cellular functions. Due to the lack of specific PKC isozyme inhibitors, it remains unknown how PKC acts on its selective target(s) and achieves its specific actions. Here we show that a PKC binding protein, enigma homolog...

journal_title：Nature neuroscience

authors： Maeno-Hikichi Y,Chang S,Matsumura K,Lai M,Lin H,Nakagawa N,Kuroda S,Zhang JF

更新日期：2003-05-01 00:00:00

abstract：:Hippocampal CA1 pyramidal neurons have frequently been regarded as a homogeneous cell population in biophysical, pharmacological and modeling studies. We found robust differences between pyramidal neurons residing in the deep and superficial CA1 sublayers in rats. Compared with their superficial peers, deep pyramidal ...

journal_title：Nature neuroscience

authors： Mizuseki K,Diba K,Pastalkova E,Buzsáki G

更新日期：2011-08-07 00:00:00

abstract：:Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...

journal_title：Nature neuroscience

authors： Pratt KG,Dong W,Aizenman CD

更新日期：2008-04-01 00:00:00

abstract：:Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipol...

journal_title：Nature neuroscience

authors： Jossin Y,Cooper JA

更新日期：2011-06-01 00:00:00

abstract：:The dorsal root ganglia (DRG) contain a variety of mechanoreceptors, but no molecular markers uniquely identify specific mechanoreceptor subtypes. We have used DNA microarrays and subtracted cDNA libraries to isolate genes that are specifically expressed by one type of mouse mechanoreceptor. The T-type calcium channel...

journal_title：Nature neuroscience

authors： Shin JB,Martinez-Salgado C,Heppenstall PA,Lewin GR

更新日期：2003-07-01 00:00:00

abstract：:Individual differences in motor learning ability are widely acknowledged, yet little is known about the factors that underlie them. Here we explore whether movement-to-movement variability in motor output, a ubiquitous if often unwanted characteristic of motor performance, predicts motor learning ability. Surprisingly...

journal_title：Nature neuroscience

authors： Wu HG,Miyamoto YR,Gonzalez Castro LN,Ölveczky BP,Smith MA

更新日期：2014-02-01 00:00:00

abstract：:A fundamental organizing principle of auditory brain circuits is tonotopy, the orderly representation of the sound frequency to which neurons are most sensitive. Tonotopy arises from the coding of frequency along the cochlea and the topographic organization of auditory pathways. The mechanisms that underlie the establ...

journal_title：Nature neuroscience

authors： Kandler K,Clause A,Noh J

更新日期：2009-06-01 00:00:00

abstract：:Humans, and animals, often encounter ambiguous situations that require a decision on whether to take an offense or a defense strategy. Behavioral studies suggest that a strategy decision is frequently made before concrete options are evaluated. It remains enigmatic, however, how a strategy is determined without explor...

journal_title：Nature neuroscience

authors： Wan X,Cheng K,Tanaka K

更新日期：2015-05-01 00:00:00

abstract：:Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibi...

journal_title：Nature neuroscience

authors： Elsayed GF,Cunningham JP

更新日期：2017-09-01 00:00:00

abstract：:Class I histone deacetylases (HDACs) Hdac1 and Hdac2 can associate together in protein complexes with transcriptional factors such as methyl-CpG-binding protein 2 (MeCP2). Given their high degree of sequence identity, we examined whether Hdac1 and Hdac2 were functionally redundant in mature mouse brain. We demonstrate...

journal_title：Nature neuroscience

authors： Mahgoub M,Adachi M,Suzuki K,Liu X,Kavalali ET,Chahrour MH,Monteggia LM

更新日期：2016-11-01 00:00:00

abstract：:The neural mechanisms that mediate the transition from a drug-naive state to a state of drug dependence and addiction are not yet known. Here we show that a discrete population of GABA(A) receptors in the mammalian ventral tegmental area (VTA) serves as a potential addiction switching mechanism by gating reward transm...

journal_title：Nature neuroscience

authors： Laviolette SR,Gallegos RA,Henriksen SJ,van der Kooy D

更新日期：2004-02-01 00:00:00

abstract：:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...

journal_title：Nature neuroscience

authors： Saygin ZM,Osher DE,Koldewyn K,Reynolds G,Gabrieli JD,Saxe RR

更新日期：2011-12-25 00:00:00

abstract：:Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link ...

journal_title：Nature neuroscience

authors： Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J

更新日期：2018-10-01 00:00:00

abstract：:The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying...

journal_title：Nature neuroscience

authors： Kiecker C,Lumsden A

更新日期：2004-11-01 00:00:00

abstract：:At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically ac...

journal_title：Nature neuroscience

authors： Faber ES,Delaney AJ,Sah P

更新日期：2005-05-01 00:00:00