Abstract：
:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural connectivity, as measured through diffusion-weighted imaging, we were able to predict functional activation to faces in the fusiform gyrus. These predictions outperformed two control models and a standard group-average benchmark. The structure-function relationship discovered from the initial participants was highly robust in predicting activation in a second group of participants, despite differences in acquisition parameters and stimuli. This approach can thus reliably estimate activation in participants who cannot perform functional imaging tasks and is an alternative to group-activation maps. Additionally, we identified cortical regions whose connectivity was highly influential in predicting face selectivity within the fusiform, suggesting a possible mechanistic architecture underlying face processing in humans.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Saygin ZM,Osher DE,Koldewyn K,Reynolds G,Gabrieli JD,Saxe RRdoi
10.1038/nn.3001subject
Has Abstractpub_date
2011-12-25 00:00:00pages
321-7issue
2eissn
1097-6256issn
1546-1726pii
nn.3001journal_volume
15pub_type
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