Abstract：
:Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent long-term depression in the juvenile mouse visual cortex. In the mature cortex, NR2B-containing preNMDARs enhanced neurotransmission in the absence of magnesium, indicating that presynaptic NMDARs may function under depolarizing conditions throughout life. Our findings indicate that NR3A relieves preNMDARs from the dual-activation requirement of ligand-binding and depolarization; the developmental removal of NR3A limits preNMDAR functionality by restoring this associative property.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Larsen RS,Corlew RJ,Henson MA,Roberts AC,Mishina M,Watanabe M,Lipton SA,Nakanishi N,Pérez-Otaño I,Weinberg RJ,Philpot BDdoi
10.1038/nn.2750subject
Has Abstractpub_date
2011-03-01 00:00:00pages
338-44issue
3eissn
1097-6256issn
1546-1726pii
nn.2750journal_volume
14pub_type
杂志文章abstract：:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...
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