Abstract:
:Blood vessels in the nervous system have traditionally been considered neutral bystanders that only passively adapt their structure and function in response to the needs of neural cells. Emerging evidence suggests, however, that vessels and angiogenic molecules actively participate in the pathogenesis of neurological disorders. Here we will discuss molecular insights into neurological disorders resulting either from excessive vessel growth (cerebral vascular malformations) or improper vessel regression (neurodegeneration and white matter lesions). These genetic insights offer alternative therapeutic options, some of which are being evaluated in the clinic.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Storkebaum E,Quaegebeur A,Vikkula M,Carmeliet Pdoi
10.1038/nn.2947subject
Has Abstractpub_date
2011-10-26 00:00:00pages
1390-7issue
11eissn
1097-6256issn
1546-1726pii
nn.2947journal_volume
14pub_type
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