Abstract：
:Despite the importance of neuropeptide release, which is evoked by long bouts of action potential activity and which regulates behavior, peptidergic vesicle movement has not been examined in living nerve terminals. Previous in vitro studies have found that secretory vesicle motion at many sites of release is constitutive: Ca(2+) does not affect the movement of small synaptic vesicles in nerve terminals or the movement of large dense core vesicles in growth cones and endocrine cells. However, in vivo imaging of a neuropeptide, atrial natriuretic factor, tagged with green fluorescent protein in larval Drosophila melanogaster neuromuscular junctions shows that peptidergic vesicle behavior in nerve terminals is sensitive to activity-induced Ca(2+) influx. Specifically, peptidergic vesicles are immobile in resting synaptic boutons but become mobile after seconds of stimulation. Vesicle movement is undirected, occurs without the use of axonal transport motors or F-actin, and aids in the depletion of undocked neuropeptide vesicles. Peptidergic vesicle mobilization and post-tetanic potentiation of neuropeptide release are sustained for minutes.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Shakiryanova D,Tully A,Hewes RS,Deitcher DL,Levitan ESdoi
10.1038/nn1377subject
Has Abstractpub_date
2005-02-01 00:00:00pages
173-8issue
2eissn
1097-6256issn
1546-1726pii
nn1377journal_volume
8pub_type
杂志文章abstract：:Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 ca...
journal_title：Nature neuroscience
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abstract：:Phasic activation of the dopamine (DA) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. This activation of DA midbrain neurons occurs via a synaptically triggered switch from low-frequency background spiking to transient high-frequency burst firing. We found t...
journal_title：Nature neuroscience
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abstract：:Neurotransmitters are released continuously at ribbon synapses in the retina and cochlea. Notably, a single ribbon synapse of inner hair cells provides the entire input to each cochlear afferent fiber. We investigated hair cell transmitter release in the postnatal rat cochlea by recording excitatory postsynaptic curre...
journal_title：Nature neuroscience
pub_type： 杂志文章
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abstract：:Candidate Drosophila olfactory receptors (ORs) provide molecular tools to investigate how the organization of the Drosophila olfactory system determines the coding of olfactory stimuli. Neurons in the third antennal segment and maxillary palp appear to express different ORs. Individual olfactory neurons send axonal pr...
journal_title：Nature neuroscience
pub_type： 杂志文章
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2008-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 评论,杂志文章,评审
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更新日期：2001-03-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2013-05-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2005-02-01 00:00:00
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更新日期：2005-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...
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更新日期：2013-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn955
更新日期：2002-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4494
更新日期：2017-03-01 00:00:00
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更新日期：2010-06-01 00:00:00
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更新日期：2011-03-01 00:00:00
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更新日期：2019-01-01 00:00:00
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更新日期：2012-06-03 00:00:00
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更新日期：2005-03-01 00:00:00
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