Abstract:
:Neurotransmitters are released continuously at ribbon synapses in the retina and cochlea. Notably, a single ribbon synapse of inner hair cells provides the entire input to each cochlear afferent fiber. We investigated hair cell transmitter release in the postnatal rat cochlea by recording excitatory postsynaptic currents (EPSCs) from afferent boutons directly abutting the ribbon synapse. EPSCs were carried by rapidly gating AMPA receptors. EPSCs were clustered in time, indicating the possibility of coordinate release. Amplitude distributions of spontaneous EPSCs were highly skewed, peaking at 0.4 nS and ranging up to 20 times larger. Hair cell depolarization increased EPSC frequency up to 150 Hz without altering the amplitude distribution. We propose that the ribbon synapse operates by multivesicular release, possibly to achieve high-frequency transmission.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Glowatzki E,Fuchs PAdoi
10.1038/nn796subject
Has Abstractpub_date
2002-02-01 00:00:00pages
147-54issue
2eissn
1097-6256issn
1546-1726pii
nn796journal_volume
5pub_type
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