Abstract：
:Active sensation requires the convergence of external stimuli with representations of body movements. We used mouse behavior, electrophysiology and optogenetics to dissect the temporal interactions among whisker movement, neural activity and sensation of touch. We photostimulated layer 4 activity in single barrels in a closed loop with whisking. Mimicking touch-related neural activity caused illusory perception of an object at a particular location, but scrambling the timing of the spikes over one whisking cycle (tens of milliseconds) did not abolish the illusion, indicating that knowledge of instantaneous whisker position is unnecessary for discriminating object locations. The illusions were induced only during bouts of directed whisking, when mice expected touch, and in the relevant barrel. Reducing activity biased behavior, consistent with a spike count code for object detection at a particular location. Our results show that mice integrate coding of touch with movement over timescales of a whisking bout to produce perception of active touch.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
O'Connor DH,Hires SA,Guo ZV,Li N,Yu J,Sun QQ,Huber D,Svoboda Kdoi
10.1038/nn.3419subject
Has Abstractpub_date
2013-07-01 00:00:00pages
958-65issue
7eissn
1097-6256issn
1546-1726pii
nn.3419journal_volume
16pub_type
杂志文章abstract：:Calcium arising through release from intracellular stores and from influx across the plasma membrane is essential for signalling by specific guidance cues and by factors that inhibit axon regeneration. The mediators of calcium influx in these cases are largely unknown. Transient receptor potential channels (TRPCs) bel...
journal_title：Nature neuroscience
pub_type： 杂志文章
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
pub_type： 杂志文章
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
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pub_type： 评论,杂志文章,评审
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更新日期：2018-05-01 00:00:00
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doi：10.1038/s41593-020-00788-z
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pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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更新日期：2012-03-27 00:00:00
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pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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更新日期：2007-09-01 00:00:00
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更新日期：1999-01-01 00:00:00
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更新日期：2002-09-01 00:00:00
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更新日期：2017-02-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2000-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 已发布勘误
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更新日期：2019-03-01 00:00:00
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更新日期：2017-01-01 00:00:00
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更新日期：2004-05-01 00:00:00
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更新日期：2011-02-01 00:00:00
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更新日期：2002-02-01 00:00:00
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