Abstract：
:Although long-term potentiation (LTP) is long-lasting, it is not permanent and decays within weeks after its induction. Little is known about the processes underlying this decay. Here we assessed the contribution of synaptic activity to LTP decay by determining the effect of the competitive NMDA receptor antagonist CPP on the decay of perforant path-dentate LTP. CPP blocked decay over a one-week period when administered daily following the induction of LTP, and blocked decay of the late, protein-synthesis-dependent phase of LTP when administered two days after LTP induction. CPP administered for a five-day period following spatial memory training enhanced subsequent memory retention. These data suggest that LTP is normally a persistent process that is actively reversed by NMDA receptor activation, and that both the early and late phases of LTP are dynamic processes regulated by NMDA receptors. These data also support the view that LTP is involved in maintaining spatial memory.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Villarreal DM,Do V,Haddad E,Derrick BEdoi
10.1038/nn776subject
Has Abstractpub_date
2002-01-01 00:00:00pages
48-52issue
1eissn
1097-6256issn
1546-1726pii
nn776journal_volume
5pub_type
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