Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors.

abstract：:Ability to integrate diverse forms of information in current thought, or working memory, is essential for human reasoning and problem solving. We used functional imaging to identify brain regions preferentially involved in maintaining integrated versus unintegrated information in working memory. For equal amounts of v...

journal_title：Nature neuroscience

authors： Prabhakaran V,Narayanan K,Zhao Z,Gabrieli JD

更新日期：2000-01-01 00:00:00

abstract：:The development of neuronal networks in the neocortex depends on control mechanisms for mitosis and migration that allow newborn neurons to find their accurate position. Multiple mitogens, neurotrophic factors, guidance molecules and their corresponding receptors are involved in this process, but the mechanisms by whi...

journal_title：Nature neuroscience

authors： Puehringer D,Orel N,Lüningschrör P,Subramanian N,Herrmann T,Chao MV,Sendtner M

更新日期：2013-04-01 00:00:00

abstract：:The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron ...

journal_title：Nature neuroscience

authors： Romanov RA,Zeisel A,Bakker J,Girach F,Hellysaz A,Tomer R,Alpár A,Mulder J,Clotman F,Keimpema E,Hsueh B,Crow AK,Martens H,Schwindling C,Calvigioni D,Bains JS,Máté Z,Szabó G,Yanagawa Y,Zhang MD,Rendeiro A,Farlik M

更新日期：2017-02-01 00:00:00

abstract：:Economic choice entails assigning values to the available options and is impaired by lesions to the orbitofrontal cortex (OFC). Recent results show that some neurons in the OFC encode the values that monkeys (Macaca mulatta) assign to different goods when they choose between them. A broad and fundamental question is h...

journal_title：Nature neuroscience

authors： Padoa-Schioppa C,Assad JA

更新日期：2008-01-01 00:00:00

abstract：:To determine the number of open Ca(2+) channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca(2+) imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca(2+) channels triggered tr...

journal_title：Nature neuroscience

authors： Bucurenciu I,Bischofberger J,Jonas P

更新日期：2010-01-01 00:00:00

abstract：:T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...

journal_title：Nature neuroscience

authors： Garber C,Soung A,Vollmer LL,Kanmogne M,Last A,Brown J,Klein RS

更新日期：2019-08-01 00:00:00

abstract：:Learning and memory are associated with the formation and modification of neuronal assemblies: populations of neurons that encode what has been learned and mediate memory retrieval upon recall. Functional studies of neuronal assemblies have progressed dramatically thanks to recent technological advances. Here we discu...

journal_title：Nature neuroscience

authors： Holtmaat A,Caroni P

更新日期：2016-12-01 00:00:00

abstract：:When sleep followed implicit training on a motor sequence, children showed greater gains in explicit sequence knowledge after sleep than adults. This greater explicit knowledge in children was linked to their higher sleep slow-wave activity and to stronger hippocampal activation at explicit knowledge retrieval. Our da...

journal_title：Nature neuroscience

authors： Wilhelm I,Rose M,Imhof KI,Rasch B,Büchel C,Born J

更新日期：2013-04-01 00:00:00

abstract：:The healthy human brain is a mosaic of varied genomes. Long interspersed element-1 (LINE-1 or L1) retrotransposition is known to create mosaicism by inserting L1 sequences into new locations of somatic cell genomes. Using a machine learning-based, single-cell sequencing approach, we discovered that somatic L1-associat...

journal_title：Nature neuroscience

authors： Erwin JA,Paquola AC,Singer T,Gallina I,Novotny M,Quayle C,Bedrosian TA,Alves FI,Butcher CR,Herdy JR,Sarkar A,Lasken RS,Muotri AR,Gage FH

更新日期：2016-12-01 00:00:00

abstract：:Recent imaging studies show that the formation of neural connections in the central nervous system is a highly dynamic process. The iterative formation and elimination of synapses and neuronal branches result in the formation of a much larger number of trial connections than is maintained in the mature brain. Neural a...

journal_title：Nature neuroscience

authors： Hua JY,Smith SJ

更新日期：2004-04-01 00:00:00

abstract：:Here we used magnetoencephalography (MEG) to investigate stages of processing in face perception in humans. We found a face-selective MEG response occurring only 100 ms after stimulus onset (the 'M100'), 70 ms earlier than previously reported. Further, the amplitude of this M100 response was correlated with successful...

journal_title：Nature neuroscience

authors： Liu J,Harris A,Kanwisher N

更新日期：2002-09-01 00:00:00

abstract：:Microcircuits composed of principal neuron and interneuron dendrites have an important role in shaping the representation of sensory information in the olfactory bulb. Here we establish the physiological features governing synaptic signaling in dendrodendritic microcircuits of olfactory bulb glomeruli. We show that de...

journal_title：Nature neuroscience

authors： Murphy GJ,Darcy DP,Isaacson JS

更新日期：2005-03-01 00:00:00

abstract：:An object viewed from different angles can be recognized and distinguished from similar distractors after the viewer has had experience watching it rotate. It has been assumed that as an observer watches the rotation, separate representations of individual views become associated with one another. However, we show her...

journal_title：Nature neuroscience

authors： Wang G,Obama S,Yamashita W,Sugihara T,Tanaka K

更新日期：2005-12-01 00:00:00

abstract：:We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density p...

journal_title：Nature neuroscience

authors： Fisher PM,Meltzer CC,Ziolko SK,Price JC,Moses-Kolko EL,Berga SL,Hariri AR

更新日期：2006-11-01 00:00:00

abstract：:Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...

journal_title：Nature neuroscience

authors： Land BB,Narayanan NS,Liu RJ,Gianessi CA,Brayton CE,Grimaldi DM,Sarhan M,Guarnieri DJ,Deisseroth K,Aghajanian GK,DiLeone RJ

更新日期：2014-02-01 00:00:00

abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...

journal_title：Nature neuroscience

authors： Lischinsky JE,Lin D

更新日期：2020-11-01 00:00:00

abstract：:Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin)...

journal_title：Nature neuroscience

authors： Wilhelm BG,Groemer TW,Rizzoli SO

更新日期：2010-12-01 00:00:00

abstract：:Multiple protein kinase C (PKC) isozymes are present in neurons, where they regulate a variety of cellular functions. Due to the lack of specific PKC isozyme inhibitors, it remains unknown how PKC acts on its selective target(s) and achieves its specific actions. Here we show that a PKC binding protein, enigma homolog...

journal_title：Nature neuroscience

authors： Maeno-Hikichi Y,Chang S,Matsumura K,Lai M,Lin H,Nakagawa N,Kuroda S,Zhang JF

更新日期：2003-05-01 00:00:00

abstract：:Illusions that produce perceptual suppression despite constant retinal input are used to manipulate visual consciousness. Here we report on a powerful variant of existing techniques, continuous flash suppression. Distinct images flashed successively at approximately 10 Hz into one eye reliably suppress an image presen...

journal_title：Nature neuroscience

authors： Tsuchiya N,Koch C

更新日期：2005-08-01 00:00:00

abstract：:Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a ∼0.3-mm3 volume from juvenile rat somatosensory neocortex, comprising ∼31,000 cells and ∼...

journal_title：Nature neuroscience

authors： Gal E,London M,Globerson A,Ramaswamy S,Reimann MW,Muller E,Markram H,Segev I

更新日期：2017-07-01 00:00:00

abstract：:Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs...

journal_title：Nature neuroscience

authors： Emes RD,Pocklington AJ,Anderson CN,Bayes A,Collins MO,Vickers CA,Croning MD,Malik BR,Choudhary JS,Armstrong JD,Grant SG

更新日期：2008-07-01 00:00:00

abstract：:Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We rep...

journal_title：Nature neuroscience

authors： Yasuda H,Barth AL,Stellwagen D,Malenka RC

更新日期：2003-01-01 00:00:00

abstract：:Neural stem and progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes and oligodendrocytes. However, the mechanisms underlying the decision of a stem cell to either self-renew or differentiate are incompletely understood. We demonstrate here that Fbw7 (F-box and WD repeat domain containing-7), the substrate re...

journal_title：Nature neuroscience

authors： Hoeck JD,Jandke A,Blake SM,Nye E,Spencer-Dene B,Brandner S,Behrens A

更新日期：2010-11-01 00:00:00

abstract：:Cell type-specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 and archaerhodopsi...

journal_title：Nature neuroscience

authors： Madisen L,Mao T,Koch H,Zhuo JM,Berenyi A,Fujisawa S,Hsu YW,Garcia AJ 3rd,Gu X,Zanella S,Kidney J,Gu H,Mao Y,Hooks BM,Boyden ES,Buzsáki G,Ramirez JM,Jones AR,Svoboda K,Han X,Turner EE,Zeng H

更新日期：2012-03-25 00:00:00

abstract：:Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...

journal_title：Nature neuroscience

authors： Womelsdorf T,Valiante TA,Sahin NT,Miller KJ,Tiesinga P

更新日期：2014-08-01 00:00:00

abstract：:Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein...

journal_title：Nature neuroscience

authors： Tian D,Stoppel LJ,Heynen AJ,Lindemann L,Jaeschke G,Mills AA,Bear MF

更新日期：2015-02-01 00:00:00

abstract：:Head-direction cells have frequently been regarded as an internal 'compass' that can be used for navigation, although there is little evidence showing a link between their activity and spatial behavior. In a navigational task requiring the use of internal cues to return to a home location without vision (path integrat...

journal_title：Nature neuroscience

authors： Valerio S,Taube JS

更新日期：2012-10-01 00:00:00

abstract：:The endocytosis of AMPA receptors is thought to be important in the expression of long-term depression (LTD) triggered by NMDA receptor activation. Although signaling pathways necessary for LTD induction have been identified, those responsible for the regulated internalization of AMPA receptors are unknown. Here we sh...

journal_title：Nature neuroscience

authors： Beattie EC,Carroll RC,Yu X,Morishita W,Yasuda H,von Zastrow M,Malenka RC

更新日期：2000-12-01 00:00:00

abstract：:Hippocampal replay during sharp-wave ripple events (SWRs) is thought to drive memory consolidation in hippocampal and cortical circuits. Changes in neocortical activity can precede SWR events, but whether and how these changes influence the content of replay remains unknown. Here we show that during sleep there is a r...

journal_title：Nature neuroscience

authors： Rothschild G,Eban E,Frank LM

更新日期：2017-02-01 00:00:00

abstract：:Although long-term potentiation (LTP) is long-lasting, it is not permanent and decays within weeks after its induction. Little is known about the processes underlying this decay. Here we assessed the contribution of synaptic activity to LTP decay by determining the effect of the competitive NMDA receptor antagonist CP...

journal_title：Nature neuroscience

authors： Villarreal DM,Do V,Haddad E,Derrick BE

更新日期：2002-01-01 00:00:00