Abstract：
:As the neural network becomes wired, postsynaptic signaling molecules are thought to control the growth of dendrites and synapses. However, how these molecules are coordinated to sculpt postsynaptic structures is less well understood. We find that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsynaptically as a receptor to transduce reverse signals into developing dendrites of mouse hippocampal neurons. Both tyrosine phosphorylation-dependent GRB4 SH2/SH3 adaptor-mediated signals and PSD-95-discs large-zona occludens-1 (PDZ) domain-dependent signals are required for inhibition of dendrite branching, whereas only PDZ interactions are necessary for spine formation and excitatory synaptic function. PICK1 and syntenin, two PDZ domain proteins, participate with ephrin-B3 in these postsynaptic activities. PICK1 has a specific role in spine and synapse formation, and syntenin promotes both dendrite pruning and synapse formation to build postsynaptic structures that are essential for neural circuits. The study thus dissects ephrin-B reverse signaling into three distinct intracellular pathways and protein-protein interactions that mediate the maturation of postsynaptic neurons.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Xu NJ,Sun S,Gibson JR,Henkemeyer Mdoi
10.1038/nn.2931subject
Has Abstractpub_date
2011-10-02 00:00:00pages
1421-9issue
11eissn
1097-6256issn
1546-1726pii
nn.2931journal_volume
14pub_type
杂志文章abstract：:An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indire...
journal_title：Nature neuroscience
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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更新日期：2011-09-11 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2018-08-01 00:00:00
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更新日期：2006-08-01 00:00:00
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更新日期：2006-04-01 00:00:00
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更新日期：2007-09-01 00:00:00
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更新日期：2011-12-11 00:00:00
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更新日期：1999-08-01 00:00:00
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更新日期：2017-01-01 00:00:00
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更新日期：2013-02-01 00:00:00
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更新日期：1999-06-01 00:00:00
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更新日期：2005-02-01 00:00:00
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更新日期：2012-06-03 00:00:00
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