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Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactions.

Abstract：

:From insects to mammals, olfactory receptor neurons (ORNs) expressing a common olfactory receptor target their axons to specific glomeruli with high precision. Here we show in Drosophila that the POU transcription factor Acj6 controls the axon targeting specificity of a subset of ORN classes, as defined by the olfactory receptors that they express. Of these classes, some require Acj6 cell-autonomously, whereas others require Acj6 cell-nonautonomously. Mosaic analyses show that cooperative targeting occurs between axon terminals of the same ORN classes and that there are hierarchical interactions among different ORN classes. We propose that the precision of ORN axon targeting derives from both intrinsic transcriptional control and extensive axon-axon interactions.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Komiyama T,Carlson JR,Luo L

doi

10.1038/nn1284

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

819-25

issue

8

eissn

1097-6256

issn

1546-1726

pii

nn1284

journal_volume

7

pub_type

杂志文章

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