Triggering the brain's pathology sensor.

abstract：:Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Only recombinant NMDA receptors composed of NR1/NR2A exhibit a fast component of desensitization similar to neuronal NMDA receptors. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc...

journal_title：Nature neuroscience

authors： Zheng F,Erreger K,Low CM,Banke T,Lee CJ,Conn PJ,Traynelis SF

更新日期：2001-09-01 00:00:00

abstract：:Over the last 10 years, optogenetics has become widespread in neuroscience for the study of how specific cell types contribute to brain functions and brain disorder states. The full impact of optogenetics will emerge only when other toolsets mature, including neural connectivity and cell phenotyping tools and neural r...

journal_title：Nature neuroscience

authors： Boyden ES

更新日期：2015-09-01 00:00:00

abstract：:Contrast is computed throughout the nervous system to encode changing inputs efficiently. The retina encodes luminance and contrast over a wide range of visual conditions and must adapt its responses to maintain sensitivity and to avoid saturation. We examined the means by which one type of adaptation allows individua...

journal_title：Nature neuroscience

authors： Oesch NW,Diamond JS

更新日期：2011-10-23 00:00:00

abstract：:Evaluating social others requires processing complex information. Nevertheless, we can rapidly form an opinion of an individual during an initial encounter. Moreover, people can vary in these opinions, even though the same information is provided. We investigated the brain mechanisms that give rise to the impressions ...

journal_title：Nature neuroscience

authors： Schiller D,Freeman JB,Mitchell JP,Uleman JS,Phelps EA

更新日期：2009-04-01 00:00:00

abstract：:The balance between proliferation and apoptosis is critical for proper development of the nervous system. Yet, little is known about molecules that regulate apoptosis of proliferative neurons. Here we identify a soluble, secreted form of CPG15 expressed in embryonic rat brain regions undergoing rapid proliferation and...

journal_title：Nature neuroscience

authors： Putz U,Harwell C,Nedivi E

更新日期：2005-03-01 00:00:00

abstract：:Neuroligins are postsynaptic cell adhesion molecules that are important for synaptic function through their trans-synaptic interaction with neurexins (NRXNs). The localization and synaptic effects of neuroligin-1 (NL-1, also called NLGN1) are specific to excitatory synapses with the capacity to enhance excitatory syna...

journal_title：Nature neuroscience

authors： Bemben MA,Shipman SL,Hirai T,Herring BE,Li Y,Badger JD 2nd,Nicoll RA,Diamond JS,Roche KW

更新日期：2014-01-01 00:00:00

abstract：:Neuronal differentiation is accomplished through cascades of intrinsic genetic factors initiated in neuronal progenitors by external gradients of morphogens. Activity has been thought to be important only late in development, but recent evidence suggests that activity also regulates early neuronal differentiation. Act...

journal_title：Nature neuroscience

authors： Marek KW,Kurtz LM,Spitzer NC

更新日期：2010-08-01 00:00:00

abstract：:In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature neuroscience

authors： Mahler SV

更新日期：2018-06-01 00:00:00

abstract：:Although long-term potentiation (LTP) is long-lasting, it is not permanent and decays within weeks after its induction. Little is known about the processes underlying this decay. Here we assessed the contribution of synaptic activity to LTP decay by determining the effect of the competitive NMDA receptor antagonist CP...

journal_title：Nature neuroscience

authors： Villarreal DM,Do V,Haddad E,Derrick BE

更新日期：2002-01-01 00:00:00

abstract：:Sensory pathways are typically studied by starting at receptor neurons and following postsynaptic neurons into the brain. However, this leads to a bias in analyses of activity toward the earliest layers of processing. Here, we present new methods for volumetric neural imaging with precise across-brain registration to ...

journal_title：Nature neuroscience

authors： Pacheco DA,Thiberge SY,Pnevmatikakis E,Murthy M

更新日期：2021-01-01 00:00:00

abstract：:Sensory neural systems use spatiotemporal coding mechanisms to represent stimuli. These time-varying response patterns sometimes outlast the stimulus. Can the temporal structure of a stimulus interfere with, or even disrupt, the spatiotemporal structure of the neural representation? We investigated this potential conf...

journal_title：Nature neuroscience

authors： Brown SL,Joseph J,Stopfer M

更新日期：2005-11-01 00:00:00

abstract：:The accessory olfactory bulb (AOB) is a critical olfactory structure that has been implicated in mediating social behavior. It receives input from the vomeronasal organ and projects to targets in the amygdaloid complex. Its anterior and posterior components (aAOB and pAOB) display molecular, connectional and functiona...

journal_title：Nature neuroscience

authors： Huilgol D,Udin S,Shimogori T,Saha B,Roy A,Aizawa S,Hevner RF,Meyer G,Ohshima T,Pleasure SJ,Zhao Y,Tole S

更新日期：2013-02-01 00:00:00

abstract：:Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form of PIKE, designated PIKE-L, which, unlike the nuclear PIKE-S, localizes to both the cytoplasm and the nucleus. We demo...

journal_title：Nature neuroscience

authors： Rong R,Ahn JY,Huang H,Nagata E,Kalman D,Kapp JA,Tu J,Worley PF,Snyder SH,Ye K

更新日期：2003-11-01 00:00:00

abstract：:To determine the number of open Ca(2+) channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca(2+) imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca(2+) channels triggered tr...

journal_title：Nature neuroscience

authors： Bucurenciu I,Bischofberger J,Jonas P

更新日期：2010-01-01 00:00:00

abstract：:Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex an...

journal_title：Nature neuroscience

authors： Kabanova A,Pabst M,Lorkowski M,Braganza O,Boehlen A,Nikbakht N,Pothmann L,Vaswani AR,Musgrove R,Di Monte DA,Sauvage M,Beck H,Blaess S

更新日期：2015-06-01 00:00:00

abstract：:The CNS, which consists of the brain and spinal cord, is continuously monitored by resident microglia and blood-borne immune cells such as macrophages, dendritic cells and T cells to detect for damaging agents that would disrupt homeostasis and optimal functioning of these vital organs. Further, the CNS must balance b...

journal_title：Nature neuroscience

authors： Ousman SS,Kubes P

更新日期：2012-07-26 00:00:00

abstract：:Although inherently linked, body form and body action may be represented in separate neural substrates. Using repetitive transcranial magnetic stimulation in healthy individuals, we show that interference with the extrastriate body area impairs the discrimination of bodily forms, and interference with the ventral prem...

journal_title：Nature neuroscience

authors： Urgesi C,Candidi M,Ionta S,Aglioti SM

更新日期：2007-01-01 00:00:00

abstract：:The efficiency of remyelination decreases with age, but the molecular mechanisms responsible for this decline remain only partially understood. In this study, we show that remyelination is regulated by age-dependent epigenetic control of gene expression. In demyelinated young brains, new myelin synthesis is preceded b...

journal_title：Nature neuroscience

authors： Shen S,Sandoval J,Swiss VA,Li J,Dupree J,Franklin RJ,Casaccia-Bonnefil P

更新日期：2008-09-01 00:00:00

abstract：:Attention powerfully influences auditory perception, but little is understood about the mechanisms whereby attention sharpens responses to unattended sounds. We used high-resolution surface mapping techniques (using functional magnetic resonance imaging, fMRI) to examine activity in human auditory cortex during an int...

journal_title：Nature neuroscience

authors： Petkov CI,Kang X,Alho K,Bertrand O,Yund EW,Woods DL

更新日期：2004-06-01 00:00:00

abstract：:Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link ...

journal_title：Nature neuroscience

authors： Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J

更新日期：2018-10-01 00:00:00

abstract：:Brain tumor initiating cells (BTICs) co-opt the neuronal high affinity glucose transporter, GLUT3, to withstand metabolic stress. We investigated another mechanism critical to brain metabolism, mitochondrial morphology, in BTICs. BTIC mitochondria were fragmented relative to non-BTIC tumor cell mitochondria, suggestin...

journal_title：Nature neuroscience

authors： Xie Q,Wu Q,Horbinski CM,Flavahan WA,Yang K,Zhou W,Dombrowski SM,Huang Z,Fang X,Shi Y,Ferguson AN,Kashatus DF,Bao S,Rich JN

更新日期：2015-04-01 00:00:00

abstract：:Sensory systems create neural representations of environmental stimuli and these representations can be associated with other stimuli through learning. Are spike patterns the neural representations that get directly associated with reinforcement during conditioning? In the moth Manduca sexta, we found that odor presen...

journal_title：Nature neuroscience

authors： Ito I,Ong RC,Raman B,Stopfer M

更新日期：2008-10-01 00:00:00

abstract：:Binocular competition is thought to drive eye-specific segregation in the developing visual system, potentially through Hebbian synaptic learning rules that are sensitive to correlations in afferent activity. Altering retinal activity can disrupt eye-specific segregation, but little is known about the temporal feature...

journal_title：Nature neuroscience

authors： Zhang J,Ackman JB,Xu HP,Crair MC

更新日期：2011-11-18 00:00:00

abstract：:Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...

journal_title：Nature neuroscience

authors： Beuming T,Kniazeff J,Bergmann ML,Shi L,Gracia L,Raniszewska K,Newman AH,Javitch JA,Weinstein H,Gether U,Loland CJ

更新日期：2008-07-01 00:00:00

abstract：:Shared neural variability is ubiquitous in cortical populations. While this variability is presumed to arise from overlapping synaptic input, its precise relationship to local circuit architecture remains unclear. We combine computational models and in vivo recordings to study the relationship between the spatial stru...

journal_title：Nature neuroscience

authors： Rosenbaum R,Smith MA,Kohn A,Rubin JE,Doiron B

更新日期：2017-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Farhan SMK,Howrigan DP,Abbott LE,Klim JR,Topp SD,Byrnes AE,Churchhouse C,Phatnani H,Smith BN,Rampersaud E,Wu G,Wuu J,Shatunov A,Iacoangeli A,Khleifat AA,Mordes DA,Ghosh S,ALSGENS Consortium.,FALS Consortium.,Project

更新日期：2020-02-01 00:00:00

abstract：:Neuronal migration disorders such as lissencephaly and subcortical band heterotopia are associated with epilepsy and intellectual disability. DCX, PAFAH1B1 and TUBA1A are mutated in these disorders; however, corresponding mouse mutants do not show heterotopic neurons in the neocortex. In contrast, spontaneously arisen...

journal_title：Nature neuroscience

authors： Kielar M,Tuy FP,Bizzotto S,Lebrand C,de Juan Romero C,Poirier K,Oegema R,Mancini GM,Bahi-Buisson N,Olaso R,Le Moing AG,Boutourlinsky K,Boucher D,Carpentier W,Berquin P,Deleuze JF,Belvindrah R,Borrell V,Welker E,Chel

更新日期：2014-07-01 00:00:00

abstract：:We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in learning and memory, and were repaired within 24 h. Increasing neu...

journal_title：Nature neuroscience

authors： Suberbielle E,Sanchez PE,Kravitz AV,Wang X,Ho K,Eilertson K,Devidze N,Kreitzer AC,Mucke L

更新日期：2013-05-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins syndrome (PTHS), a syndromic form of ASD caused by mutations in the TCF4 gene, but not the T...

journal_title：Nature neuroscience

authors： Phan BN,Bohlen JF,Davis BA,Ye Z,Chen HY,Mayfield B,Sripathy SR,Cerceo Page S,Campbell MN,Smith HL,Gallop D,Kim H,Thaxton CL,Simon JM,Burke EE,Shin JH,Kennedy AJ,Sweatt JD,Philpot BD,Jaffe AE,Maher BJ

更新日期：2020-03-01 00:00:00

abstract：:In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation w...

journal_title：Nature neuroscience

authors： Paton JF,Abdala AP,Koizumi H,Smith JC,St-John WM

更新日期：2006-03-01 00:00:00