Visual map development depends on the temporal pattern of binocular activity in mice.

abstract：:Growing evidence suggests that the recognition of different emotional states involves at least partly separable neural circuits. Here we assessed the discrimination of both anger and happiness in healthy subjects receiving transcranial magnetic stimulation (TMS) over the medial-frontal cortex or over a control site (m...

journal_title：Nature neuroscience

authors： Harmer CJ,Thilo KV,Rothwell JC,Goodwin GM

更新日期：2001-01-01 00:00:00

abstract：:In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...

journal_title：Nature neuroscience

authors： Alonso JM,Martinez LM

更新日期：1998-09-01 00:00:00

abstract：:Most advances in addiction treatment to date have addressed the physical dependence and withdrawal that accompany addiction to some drugs of abuse. In contrast, it has proven more difficult to develop medications that effectively treat drug craving and relapse, the core features of addictive disorders. Current efforts...

journal_title：Nature neuroscience

authors： Nestler EJ

更新日期：2002-11-01 00:00:00

abstract：:Humans, and animals, often encounter ambiguous situations that require a decision on whether to take an offense or a defense strategy. Behavioral studies suggest that a strategy decision is frequently made before concrete options are evaluated. It remains enigmatic, however, how a strategy is determined without explor...

journal_title：Nature neuroscience

authors： Wan X,Cheng K,Tanaka K

更新日期：2015-05-01 00:00:00

abstract：:Sharp wave-associated field oscillations (∼200 Hz) of the hippocampus, referred to as ripples, are believed to be important for consolidation of explicit memory. Little is known about how ripples are regulated by other brain regions. We found that the median raphe region (MnR) is important for regulating hippocampal r...

journal_title：Nature neuroscience

authors： Wang DV,Yau HJ,Broker CJ,Tsou JH,Bonci A,Ikemoto S

更新日期：2015-05-01 00:00:00

abstract：:The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed...

journal_title：Nature neuroscience

authors： McLean DL,Masino MA,Koh IY,Lindquist WB,Fetcho JR

更新日期：2008-12-01 00:00:00

abstract：:Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex an...

journal_title：Nature neuroscience

authors： Kabanova A,Pabst M,Lorkowski M,Braganza O,Boehlen A,Nikbakht N,Pothmann L,Vaswani AR,Musgrove R,Di Monte DA,Sauvage M,Beck H,Blaess S

更新日期：2015-06-01 00:00:00

abstract：:Dot patterns sliding transparently across one another are normally perceived as independently moving surfaces. Recordings from direction-selective neurons in area MT of the macaque suggested that this perceptual segregation did not depend on the presence of two peaks in the population activity. Rather, the visual syst...

journal_title：Nature neuroscience

authors： Treue S,Hol K,Rauber HJ

更新日期：2000-03-01 00:00:00

abstract：:The mechanism by which adult neural stem cells (NSCs) are established during development is unclear. In this study, analysis of cell cycle progression by examining retention of a histone 2B (H2B)-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows betwe...

journal_title：Nature neuroscience

authors： Furutachi S,Miya H,Watanabe T,Kawai H,Yamasaki N,Harada Y,Imayoshi I,Nelson M,Nakayama KI,Hirabayashi Y,Gotoh Y

更新日期：2015-05-01 00:00:00

abstract：:The endocytosis of AMPA receptors (AMPARs) underlies several forms of synaptic plasticity, including NMDA receptor (NMDAR)-dependent long-term depression (LTD), but the molecular mechanisms responsible for this trafficking remain unknown. We found that PSD-95, a major postsynaptic density protein, is important for NMD...

journal_title：Nature neuroscience

authors： Bhattacharyya S,Biou V,Xu W,Schlüter O,Malenka RC

更新日期：2009-02-01 00:00:00

abstract：:Very little is known about how stimuli that are typically not rich in sugars, such as beer, trigger attractive gustatory responses in Drosophila. We identified a member of the gustatory receptor family, Gr64e, as a receptor that is required for feeding preference for beer and other sources that have fermenting yeast. ...

journal_title：Nature neuroscience

authors： Wisotsky Z,Medina A,Freeman E,Dahanukar A

更新日期：2011-11-06 00:00:00

abstract：:Neurobiological theories of knowledge processing are biased toward the language-dominant (usually the left) hemisphere. Does the right hemisphere critically contribute to knowledge processing? J.A. is a left-hemisphere language-dominant individual who suffered a lesion confined to the right mid- and anterior fusiform ...

journal_title：Nature neuroscience

authors： Vandenbulcke M,Peeters R,Fannes K,Vandenberghe R

更新日期：2006-07-01 00:00:00

abstract：:Brain neural stem cells (radial glial progenitors, RGPs) undergo a mysterious form of cell cycle-entrained interkinetic nuclear migration (INM) that is driven apically by cytoplasmic dynein and basally by the kinesin KIF1A, which has recently been implicated in human brain developmental disease. To understand the cons...

journal_title：Nature neuroscience

authors： Carabalona A,Hu DJ,Vallee RB

更新日期：2016-02-01 00:00:00

abstract：:Ca(v)2.1 channels, which mediate P/Q-type Ca2+ currents, undergo Ca2+/calmodulin (CaM)-dependent inactivation and facilitation that can significantly alter synaptic efficacy. Here we report that the neuronal Ca2+-binding protein 1 (CaBP1) modulates Ca(v)2.1 channels in a manner that is markedly different from modulati...

journal_title：Nature neuroscience

authors： Lee A,Westenbroek RE,Haeseleer F,Palczewski K,Scheuer T,Catterall WA

更新日期：2002-03-01 00:00:00

abstract：:Here we used magnetoencephalography (MEG) to investigate stages of processing in face perception in humans. We found a face-selective MEG response occurring only 100 ms after stimulus onset (the 'M100'), 70 ms earlier than previously reported. Further, the amplitude of this M100 response was correlated with successful...

journal_title：Nature neuroscience

authors： Liu J,Harris A,Kanwisher N

更新日期：2002-09-01 00:00:00

abstract：:Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...

journal_title：Nature neuroscience

authors： Galli R,Borello U,Gritti A,Minasi MG,Bjornson C,Coletta M,Mora M,De Angelis MG,Fiocco R,Cossu G,Vescovi AL

更新日期：2000-10-01 00:00:00

abstract：:The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...

journal_title：Nature neuroscience

authors： Prinz M,Priller J

更新日期：2017-02-01 00:00:00

abstract：:We used ultrasound image-guided injections of high-titer retroviral vectors to obtain widespread introduction of genes into the mouse nervous system in utero as early as embryonic day 8.5 (E8.5). The vectors used included internal promoters that substantially improved proviral gene expression in the ventricular zone o...

journal_title：Nature neuroscience

authors： Gaiano N,Kohtz JD,Turnbull DH,Fishell G

更新日期：1999-09-01 00:00:00

abstract：:Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood. We found that neuronal deletion of Hdac3 in mice el...

journal_title：Nature neuroscience

authors： Nott A,Cheng J,Gao F,Lin YT,Gjoneska E,Ko T,Minhas P,Zamudio AV,Meng J,Zhang F,Jin P,Tsai LH

更新日期：2016-11-01 00:00:00

abstract：:Individuals' risk attitudes are known to guide choices about uncertain options. However, in the presence of others' decisions, these choices can be swayed and manifest as riskier or safer behavior than one would express alone. To test the mechanisms underlying effective social 'nudges' in human decision-making, we use...

journal_title：Nature neuroscience

authors： Chung D,Christopoulos GI,King-Casas B,Ball SB,Chiu PH

更新日期：2015-06-01 00:00:00

abstract：:Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipol...

journal_title：Nature neuroscience

authors： Jossin Y,Cooper JA

更新日期：2011-06-01 00:00:00

abstract：:An afterimage looks larger when one fixates on a distant than on a closer surface. We show that the retinotopic activity in the primary visual cortex (V1) associated with viewing an afterimage is modulated by perceived size, even when the size of the retinal image remains constant. This suggests that V1 has an importa...

journal_title：Nature neuroscience

authors： Sperandio I,Chouinard PA,Goodale MA

更新日期：2012-03-11 00:00:00

abstract：:The ability to attribute mental states to others, and therefore to predict others' behavior, is particularly advanced in humans. A controversial but untested idea is that this is achieved by simulating the other person's mental processes in one's own mind. If this is the case, then the same neural systems activated by...

journal_title：Nature neuroscience

authors： Ramnani N,Miall RC

更新日期：2004-01-01 00:00:00

abstract：:The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which is characterized by changes in the tau protein and in the cleaved fragments of the amyloid precursor protein (APP). We used a high-resolution functional magnetic resonance imaging (fMRI) variant that can map metabolic defects i...

journal_title：Nature neuroscience

authors： Khan UA,Liu L,Provenzano FA,Berman DE,Profaci CP,Sloan R,Mayeux R,Duff KE,Small SA

更新日期：2014-02-01 00:00:00

abstract：:Neurotransmitter transporters can affect neuronal excitability indirectly via modulation of neurotransmitter concentrations or directly via transporter currents. A physiological or pathophysiological role for transporter currents has not been described. We found that GABA transporter 1 (GAT-1) cation currents directly...

journal_title：Nature neuroscience

authors： Bagley EE,Hacker J,Chefer VI,Mallet C,McNally GP,Chieng BC,Perroud J,Shippenberg TS,Christie MJ

更新日期：2011-10-30 00:00:00

abstract：:Differentiation of CNS glia is regulated by Notch signaling through neuron-glia interaction. Here, we identified Delta/Notch-like EGF-related receptor (DNER), a neuron-specific transmembrane protein, as a previously unknown ligand of Notch during cellular morphogenesis of Bergmann glia in the mouse cerebellum. DNER bi...

journal_title：Nature neuroscience

authors： Eiraku M,Tohgo A,Ono K,Kaneko M,Fujishima K,Hirano T,Kengaku M

更新日期：2005-07-01 00:00:00

abstract：:The dorsal root ganglia (DRG) contain a variety of mechanoreceptors, but no molecular markers uniquely identify specific mechanoreceptor subtypes. We have used DNA microarrays and subtracted cDNA libraries to isolate genes that are specifically expressed by one type of mouse mechanoreceptor. The T-type calcium channel...

journal_title：Nature neuroscience

authors： Shin JB,Martinez-Salgado C,Heppenstall PA,Lewin GR

更新日期：2003-07-01 00:00:00

abstract：:An action may lead to either a reward or a punishment. Therefore, an appropriate action needs to be chosen on the basis of the values of both expected rewards and expected punishments. To understand the underlying neural mechanisms, we conditioned monkeys using a Pavlovian procedure with two distinct contexts: one in ...

journal_title：Nature neuroscience

authors： Matsumoto M,Hikosaka O

更新日期：2009-01-01 00:00:00

abstract：:Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in est...

journal_title：Nature neuroscience

authors： Feng J,Nestler EJ

更新日期：2010-09-01 00:00:00

abstract：:Blood vessels in the nervous system have traditionally been considered neutral bystanders that only passively adapt their structure and function in response to the needs of neural cells. Emerging evidence suggests, however, that vessels and angiogenic molecules actively participate in the pathogenesis of neurological ...

journal_title：Nature neuroscience

authors： Storkebaum E,Quaegebeur A,Vikkula M,Carmeliet P

更新日期：2011-10-26 00:00:00