Abstract：
:Sharp wave-associated field oscillations (∼200 Hz) of the hippocampus, referred to as ripples, are believed to be important for consolidation of explicit memory. Little is known about how ripples are regulated by other brain regions. We found that the median raphe region (MnR) is important for regulating hippocampal ripple activity and memory consolidation. We performed in vivo simultaneous recording in the MnR and hippocampus of mice and found that, when a group of MnR neurons was active, ripples were absent. Consistently, optogenetic stimulation of MnR neurons suppressed ripple activity and inhibition of these neurons increased ripple activity. Notably, using a fear conditioning procedure, we found that photostimulation of MnR neurons interfered with memory consolidation. Our results demonstrate a critical role of the MnR in regulating ripples and memory consolidation.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Wang DV,Yau HJ,Broker CJ,Tsou JH,Bonci A,Ikemoto Sdoi
10.1038/nn.3998subject
Has Abstractpub_date
2015-05-01 00:00:00pages
728-35issue
5eissn
1097-6256issn
1546-1726pii
nn.3998journal_volume
18pub_type
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