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Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex.

Abstract：

:The cerebral cortex has the ability to adapt to altered sensory inputs. In the visual cortex, a small lesion to the retina causes the deprived cortical region to become responsive to adjacent parts of the visual field. This extensive topographic remapping is assumed to be mediated by the rewiring of intracortical connections, but the dynamics of this reorganization process remain unknown. We used repeated intrinsic signal and two-photon imaging to monitor functional and structural alterations in adult mouse visual cortex over a period of months following a retinal lesion. The rate at which dendritic spines were lost and gained increased threefold after a small retinal lesion, leading to an almost complete replacement of spines in the deafferented cortex within 2 months. Because this massive remodeling of synaptic structures did not occur when all visual input was removed, it likely reflects the activity-dependent establishment of new cortical circuits that serve the recovery of visual responses.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Keck T,Mrsic-Flogel TD,Vaz Afonso M,Eysel UT,Bonhoeffer T,Hübener M

doi

10.1038/nn.2181

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1162-7

issue

10

eissn

1097-6256

issn

1546-1726

pii

nn.2181

journal_volume

11

pub_type

杂志文章

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