Abstract：
:The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These myeloid cells in the CNS parenchyma and at CNS-periphery interfaces are highly specialized but also extremely plastic cells that immediately react to any changes in CNS homeostasis and become reactive in the context of neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease. However, when the blood-brain barrier is impaired during CNS diseases such as multiple sclerosis or altered with cerebral ischemia, peripheral adaptive and innate immune cells, including monocytes, neutrophils, T cells and B cells, can enter the CNS, where they execute distinct cell-mediated effects. On the basis of these observations, we assess strategies for targeting peripheral immune cells to reduce CNS disease burden.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Prinz M,Priller Jdoi
10.1038/nn.4475subject
Has Abstractpub_date
2017-02-01 00:00:00pages
136-144issue
2eissn
1097-6256issn
1546-1726pii
nn.4475journal_volume
20pub_type
杂志文章,评审abstract：:The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for vocal learning in juvenile songbirds. The shell subregion of LMAN (LMAN(shell)) gives rise to recurrent loops that may subserve specific learning-related functions....
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
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doi：10.1038/nn1921
更新日期：2007-07-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4442
更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.2151
更新日期：2008-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.3249
更新日期：2012-12-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2002-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.2901
更新日期：2011-09-11 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2172
更新日期：2008-09-01 00:00:00
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更新日期：2018-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1305
更新日期：2004-09-01 00:00:00
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更新日期：2019-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3449
更新日期：2013-08-01 00:00:00
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更新日期：2007-10-01 00:00:00
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更新日期：2016-02-01 00:00:00
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更新日期：2006-12-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2010-05-01 00:00:00
abstract：:Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked end...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1126
更新日期：2003-10-01 00:00:00
abstract：:Social behaviors recruit multiple cognitive operations that require interactions between cortical and subcortical brain regions. Interareal synchrony may facilitate such interactions between cortical and subcortical neural populations. However, it remains unknown how neurons from different nodes in the social brain ne...
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更新日期：2020-04-01 00:00:00
abstract：:Dopamine is vital for coordinated motion and for association learning linked to behavioral reinforcement. Here we show that the precise overlap of striatal dopaminergic and cholinergic fibers underlies potent control of dopamine release by ongoing nicotinic receptor activity. In mouse striatal slices, nicotinic antago...
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pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/74865
更新日期：2000-05-01 00:00:00
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更新日期：2005-05-01 00:00:00
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更新日期：2010-06-01 00:00:00
