Neural correlates of prickle sensation: a percept-related fMRI study.

abstract：:The auditory system encodes sound by decomposing the amplitude signal arriving at the ear into multiple frequency bands whose center frequencies and bandwidths are approximately exponential functions of the distance from the stapes. This organization is thought to result from the adaptation of cochlear mechanisms to t...

journal_title：Nature neuroscience

authors： Lewicki MS

更新日期：2002-04-01 00:00:00

abstract：:Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment...

journal_title：Nature neuroscience

authors： Girardeau G,Benchenane K,Wiener SI,Buzsáki G,Zugaro MB

更新日期：2009-10-01 00:00:00

abstract：:Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of disability for almost three decades. Past molecular studies of MDD employed bulk homogenates of postmortem brain tissue, which obscures gene expression changes withi...

journal_title：Nature neuroscience

authors： Nagy C,Maitra M,Tanti A,Suderman M,Théroux JF,Davoli MA,Perlman K,Yerko V,Wang YC,Tripathy SJ,Pavlidis P,Mechawar N,Ragoussis J,Turecki G

更新日期：2020-06-01 00:00:00

abstract：:We demonstrate a form of long-term depression (LTD) in the perirhinal cortex that relies on interaction between different glutamate receptors. Group II metabotropic glutamate (mGlu) receptors facilitated group I mGlu receptor-mediated increases in intracellular calcium. This facilitation plus NMDA receptor activation ...

journal_title：Nature neuroscience

authors： Cho K,Kemp N,Noel J,Aggleton JP,Brown MW,Bashir ZI

更新日期：2000-02-01 00:00:00

abstract：:Parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss of dopaminergic neurons innervating the striatum. As striatal dopamine levels fall, striatal acetylcholine release rises, exacerbating motor symptoms. This adaptation is commonly attributed to the loss of interneuronal regulation b...

journal_title：Nature neuroscience

authors： Ding J,Guzman JN,Tkatch T,Chen S,Goldberg JA,Ebert PJ,Levitt P,Wilson CJ,Hamm HE,Surmeier DJ

更新日期：2006-06-01 00:00:00

abstract：:Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis can be highly time consuming. In motor control studies, humans or other...

journal_title：Nature neuroscience

authors： Mathis A,Mamidanna P,Cury KM,Abe T,Murthy VN,Mathis MW,Bethge M

更新日期：2018-09-01 00:00:00

abstract：:Many attempts to obtain reliable self-administration behavior by laboratory animals with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsuccessful. Because self-administration behavior has been demonstrated in laboratory animals for almost all other psychoactive drugs abused ...

journal_title：Nature neuroscience

authors： Tanda G,Munzar P,Goldberg SR

更新日期：2000-11-01 00:00:00

abstract：:Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is unique to resilience. Zfp189, which encodes a previously unstudied zin...

journal_title：Nature neuroscience

authors： Lorsch ZS,Hamilton PJ,Ramakrishnan A,Parise EM,Salery M,Wright WJ,Lepack AE,Mews P,Issler O,McKenzie A,Zhou X,Parise LF,Pirpinias ST,Ortiz Torres I,Kronman HG,Montgomery SE,Loh YE,Labonté B,Conkey A,Symonds AE,Nev

更新日期：2019-09-01 00:00:00

abstract：:Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipol...

journal_title：Nature neuroscience

authors： Jossin Y,Cooper JA

更新日期：2011-06-01 00:00:00

abstract：:The origin of brain mechanisms that support human language-whether these originated de novo in humans or evolved from a neural substrate that existed in a common ancestor-remains a controversial issue. Although the answer is not provided by the fossil record, it is possible to make inferences by studying living specie...

journal_title：Nature neuroscience

authors： Gil-da-Costa R,Martin A,Lopes MA,Muñoz M,Fritz JB,Braun AR

更新日期：2006-08-01 00:00:00

abstract：:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...

journal_title：Nature neuroscience

authors： Stoodley CJ,D'Mello AM,Ellegood J,Jakkamsetti V,Liu P,Nebel MB,Gibson JM,Kelly E,Meng F,Cano CA,Pascual JM,Mostofsky SH,Lerch JP,Tsai PT

更新日期：2017-12-01 00:00:00

abstract：:Polyamines are endogenous molecules involved in cell damage following neurological insults, although it is unclear whether polyamines reduce or exacerbate this damage. We used a developmental seizure model in which we exposed Xenopus laevis tadpoles to pentylenetetrazole (PTZ), a known convulsant. We found that, after...

journal_title：Nature neuroscience

authors： Bell MR,Belarde JA,Johnson HF,Aizenman CD

更新日期：2011-04-01 00:00:00

abstract：:Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca2+ imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex...

journal_title：Nature neuroscience

authors： Ranganathan GN,Apostolides PF,Harnett MT,Xu NL,Druckmann S,Magee JC

更新日期：2018-11-01 00:00:00

abstract：:Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...

journal_title：Nature neuroscience

authors： Mainland JD,Keller A,Li YR,Zhou T,Trimmer C,Snyder LL,Moberly AH,Adipietro KA,Liu WL,Zhuang H,Zhan S,Lee SS,Lin A,Matsunami H

更新日期：2014-01-01 00:00:00

abstract：:All the higher mental and cognitive functions unique to humans depend on the neocortex ('new' cortex, referring to its relatively recent appearance in evolution), which is divided into discrete areas that subserve distinct functions, such as language, movement and sensation. With a few notable exceptions, all neocorti...

journal_title：Nature neuroscience

authors： Monuki ES,Walsh CA

更新日期：2001-11-01 00:00:00

abstract：:Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here we demonstrate a central role for capillary endothelial cells in sensing neural activity and communicating it to upstream arterioles in the form of an el...

journal_title：Nature neuroscience

authors： Longden TA,Dabertrand F,Koide M,Gonzales AL,Tykocki NR,Brayden JE,Hill-Eubanks D,Nelson MT

更新日期：2017-05-01 00:00:00

abstract：:In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation w...

journal_title：Nature neuroscience

authors： Paton JF,Abdala AP,Koizumi H,Smith JC,St-John WM

更新日期：2006-03-01 00:00:00

abstract：:Several ion channels are thought to be directly modulated by nitric oxide (NO), but the molecular basis of this regulation is unclear. Here we show that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO. Site-directed mutagenesis identified a critical cys...

journal_title：Nature neuroscience

authors： Choi YB,Tenneti L,Le DA,Ortiz J,Bai G,Chen HS,Lipton SA

更新日期：2000-01-01 00:00:00

abstract：:Neural stem and progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes and oligodendrocytes. However, the mechanisms underlying the decision of a stem cell to either self-renew or differentiate are incompletely understood. We demonstrate here that Fbw7 (F-box and WD repeat domain containing-7), the substrate re...

journal_title：Nature neuroscience

authors： Hoeck JD,Jandke A,Blake SM,Nye E,Spencer-Dene B,Brandner S,Behrens A

更新日期：2010-11-01 00:00:00

abstract：:Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...

journal_title：Nature neuroscience

authors： Gentet LJ,Kremer Y,Taniguchi H,Huang ZJ,Staiger JF,Petersen CC

更新日期：2012-02-26 00:00:00

abstract：:Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of ...

journal_title：Nature neuroscience

authors： Tellez LA,Han W,Zhang X,Ferreira TL,Perez IO,Shammah-Lagnado SJ,van den Pol AN,de Araujo IE

更新日期：2016-03-01 00:00:00

abstract：:Exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (NAc)-based behaviors, yet produce very different adaptations at NAc excitatory synapses. In an effort to explain this paradox, we found that both drugs induced NMDA receptor-containing, AMPA receptor-silent excitatory synapses, albeit ...

journal_title：Nature neuroscience

authors： Graziane NM,Sun S,Wright WJ,Jang D,Liu Z,Huang YH,Nestler EJ,Wang YT,Schlüter OM,Dong Y

更新日期：2016-07-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in...

journal_title：Nature neuroscience

authors： Takenaka MC,Gabriely G,Rothhammer V,Mascanfroni ID,Wheeler MA,Chao CC,Gutiérrez-Vázquez C,Kenison J,Tjon EC,Barroso A,Vandeventer T,de Lima KA,Rothweiler S,Mayo L,Ghannam S,Zandee S,Healy L,Sherr D,Farez MF,Prat A,

更新日期：2019-05-01 00:00:00

abstract：:Previous gene knockout studies have shown that the orphan glutamate receptor delta2 (GluRdelta2) is critically involved in synaptogenesis between parallel fibers and Purkinje cells during development. However, the precise function of GluRdelta2 and whether it is functional in the mature cerebellum remain unclear. To a...

journal_title：Nature neuroscience

authors： Hirai H,Launey T,Mikawa S,Torashima T,Yanagihara D,Kasaura T,Miyamoto A,Yuzaki M

更新日期：2003-08-01 00:00:00

abstract：:Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhi...

journal_title：Nature neuroscience

authors： Couey JJ,Witoelar A,Zhang SJ,Zheng K,Ye J,Dunn B,Czajkowski R,Moser MB,Moser EI,Roudi Y,Witter MP

更新日期：2013-03-01 00:00:00

abstract：:Calcium arising through release from intracellular stores and from influx across the plasma membrane is essential for signalling by specific guidance cues and by factors that inhibit axon regeneration. The mediators of calcium influx in these cases are largely unknown. Transient receptor potential channels (TRPCs) bel...

journal_title：Nature neuroscience

authors： Shim S,Goh EL,Ge S,Sailor K,Yuan JP,Roderick HL,Bootman MD,Worley PF,Song H,Ming GL

更新日期：2005-06-01 00:00:00

abstract：:The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic regulation and nongenomic mechanisms. A key result of stress is structural remodeling of neural architecture, which may be a si...

journal_title：Nature neuroscience

authors： McEwen BS,Bowles NP,Gray JD,Hill MN,Hunter RG,Karatsoreos IN,Nasca C

更新日期：2015-10-01 00:00:00

abstract：:As the neural network becomes wired, postsynaptic signaling molecules are thought to control the growth of dendrites and synapses. However, how these molecules are coordinated to sculpt postsynaptic structures is less well understood. We find that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsyna...

journal_title：Nature neuroscience

authors： Xu NJ,Sun S,Gibson JR,Henkemeyer M

更新日期：2011-10-02 00:00:00

abstract：:Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that ...

journal_title：Nature neuroscience

authors： Ueno M,Ueno-Nakamura Y,Niehaus J,Popovich PG,Yoshida Y

更新日期：2016-06-01 00:00:00

abstract：:The healthy human brain is a mosaic of varied genomes. Long interspersed element-1 (LINE-1 or L1) retrotransposition is known to create mosaicism by inserting L1 sequences into new locations of somatic cell genomes. Using a machine learning-based, single-cell sequencing approach, we discovered that somatic L1-associat...

journal_title：Nature neuroscience

authors： Erwin JA,Paquola AC,Singer T,Gallina I,Novotny M,Quayle C,Bedrosian TA,Alves FI,Butcher CR,Herdy JR,Sarkar A,Lasken RS,Muotri AR,Gage FH

更新日期：2016-12-01 00:00:00