Abstract：
:We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
McNamara CG,Tejero-Cantero Á,Trouche S,Campo-Urriza N,Dupret Ddoi
10.1038/nn.3843subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1658-60issue
12eissn
1097-6256issn
1546-1726pii
nn.3843journal_volume
17pub_type
杂志文章abstract：:Olfaction has often been described as a ‘synthetic’ sense. A study now reveals a surprising capacity to resolve individual odorants in complex mixtures, with implications for how the nervous system recognizes objects. ...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章
doi：10.1038/nn.3796
更新日期：2014-09-01 00:00:00
abstract：:The 'cognitive map' hypothesis proposes that brain builds a unified representation of the spatial environment to support memory and guide future action. Forty years of electrophysiological research in rodents suggest that cognitive maps are neurally instantiated by place, grid, border and head direction cells in the h...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4656
更新日期：2017-10-26 00:00:00
abstract：:Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2076
更新日期：2008-04-01 00:00:00
abstract：:Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar geno...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0155-8
更新日期：2018-06-01 00:00:00
abstract：:Microglia, the brain's intrinsic immune cells, rapidly sense brain injury and help clear cellular debris. Haynes et al. now show that P2Y12 receptors are critical for activating microglia and directing them to the site of injury. ...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章
doi：10.1038/nn1206-1463
更新日期：2006-12-01 00:00:00
abstract：:Most neurons in macaque area MT are selective for the direction of stimulus motion. By comparing direction selectivity for gratings and plaids, we classified MT neurons as pattern direction selective (PDS) or component direction selective (CDS). We compared the time course of responses in CDS and PDS neurons in opiate...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1382
更新日期：2005-02-01 00:00:00
abstract：:Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation has been implicated in a wide range of diseases. Here we demonstrate that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like recepto...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3449
更新日期：2013-08-01 00:00:00
abstract：:Behavior-contingent network oscillations bring about transient, functionally coherent neuronal assemblies in the cerebral cortex, including the hippocampus. Inhibitory input on and close to the soma is believed to phase intrinsic oscillations and output of pyramidal cells, but the function of GABA release to pyramidal...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1159
更新日期：2004-01-01 00:00:00
abstract：:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1626
更新日期：2006-02-01 00:00:00
abstract：:Although much learning occurs through direct experience of errors, humans and other animals can learn from the errors of other individuals. The medial frontal cortex (MFC) processes self-generated errors, but the neuronal architecture and mechanisms underlying the monitoring of others' errors are poorly understood. Ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3180
更新日期：2012-09-01 00:00:00
abstract：:Class I histone deacetylases (HDACs) Hdac1 and Hdac2 can associate together in protein complexes with transcriptional factors such as methyl-CpG-binding protein 2 (MeCP2). Given their high degree of sequence identity, we examined whether Hdac1 and Hdac2 were functionally redundant in mature mouse brain. We demonstrate...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4395
更新日期：2016-11-01 00:00:00
abstract：:Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3491
更新日期：2013-10-01 00:00:00
abstract：:Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3604
更新日期：2014-03-01 00:00:00
abstract：:A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and brain damage. Despite the involvement of distinct proteins in different NDs, the process of protein misfolding and aggregation is remarka...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-018-0235-9
更新日期：2018-10-01 00:00:00
abstract：:Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fe...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4084
更新日期：2015-09-01 00:00:00
abstract：:The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses of the cholinergic system. After release into the synaptic cleft, ACh is rapidly degraded by acetylcholinesterase (AChE). We have identified a mutation in the ache gene of the zebrafish, which abolishes ACh hydrolysis in ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn788
更新日期：2002-02-01 00:00:00
abstract：:Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensembl...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3669
更新日期：2014-04-01 00:00:00
abstract：:Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3657
更新日期：2014-04-01 00:00:00
abstract：:Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1672
更新日期：2006-04-01 00:00:00
abstract：:Myelinating cells, oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system produce an enormous amount of plasma membrane during the myelination process, making them particularly susceptible to disruptions of the secretory pathway. Endoplasmic reticulum stress, initiated by the accumulation of un...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.2273
更新日期：2009-04-01 00:00:00
abstract：:Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1980
更新日期：2007-10-01 00:00:00
abstract：:Ongoing sensory input is critical for shaping internal representations of the external world. Conversely, a lack of sensory input can profoundly perturb the formation of these representations. The olfactory system is particularly vulnerable to sensory deprivation, owing to the widespread prevalence of allergic, viral ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3186
更新日期：2012-09-01 00:00:00
abstract：:Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitively address the in viv...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2862
更新日期：2011-07-10 00:00:00
abstract：:The mammalian visual system contains an extensive web of feedback connections projecting from higher cortical areas to lower areas, including primary visual cortex. Although multiple theories have been proposed, the role of these connections in perceptual processing is not understood. We found that the pattern of func...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2218
更新日期：2008-12-01 00:00:00
abstract：:The production of hippocampal granule neurons continues throughout adulthood but dramatically decreases in old age. Here we show that reducing corticosteroid levels in aged rats restored the rate of cell proliferation, resulting in increased numbers of new granule neurons. This result indicates that the neuronal precu...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/13197
更新日期：1999-10-01 00:00:00
abstract：:Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0370-y
更新日期：2019-05-01 00:00:00
abstract：:Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear. Activity-dependent transcription of genes for neurotrophins such as brain-derived neurotrophic factor (BDNF) has been shown to promote epileptogenesis; however, little is known a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3005
更新日期：2011-12-11 00:00:00
abstract：:The US government is re-examining how it funds science, but it remains to be seen whether the administration can overcome tradition and bureaucratic inertia and achieve a substantial renovation of the grants peer-review system. ...
journal_title：Nature neuroscience
pub_type： 社论
doi：10.1038/nn0208-119
更新日期：2008-02-01 00:00:00
abstract：:Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in est...
journal_title：Nature neuroscience
pub_type： 评论,新闻
doi：10.1038/nn0910-1039
更新日期：2010-09-01 00:00:00
abstract：:Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-00761-w
更新日期：2020-12-21 00:00:00
