Abstract:
:Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that these spines undergo enlargements in their postsynaptic densities (PSDs). A greater proportion of profilin-containing spines with enlarged PSDs could contribute to the enhancement of associatively induced synaptic responses in the lateral amygdala following fear learning.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Lamprecht R,Farb CR,Rodrigues SM,LeDoux JEdoi
10.1038/nn1672subject
Has Abstractpub_date
2006-04-01 00:00:00pages
481-3issue
4eissn
1097-6256issn
1546-1726pii
nn1672journal_volume
9pub_type
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