Abstract:
:Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic interneurons led to deficits in auditory event-related potentials and seizure manifestation, whereas the restoration of MeCP2 in specific classes of interneurons ameliorated these deficits.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Goffin D,Brodkin ES,Blendy JA,Siegel SJ,Zhou Zdoi
10.1038/nn.3710subject
Has Abstractpub_date
2014-06-01 00:00:00pages
804-6issue
6eissn
1097-6256issn
1546-1726pii
nn.3710journal_volume
17pub_type
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